Synovitis, acne, pustulosis, hyperostosis, osteitis (SAPHO) syndrome in childhood: A report of ten cases and review of the literature

European Journal of Pediatrics

Volumn 159, Issue 8, 2000, Pages 594-601

  Beretta Piccoli, Benedetta C ^a   Sauvain, Marie J ^a   Gal, Imre ^a   Schibler, Andreas ^a   Saurenmann, Traudel ^b   Kressebuch, Helene ^a   Bianchetti, Mario G ^a  

^a UNIVERSITY OF BERN   (Switzerland)

^b UNIVERSITY OF ZURICH   (Switzerland)

Author keywords

Acne; Ankylosing spondylitis; Arthritis; Chronic recurrent multifocal osteomyelitis; Osteomyelitis; SAPHO syndrome; Skin diseases

Indexed keywords

ACNE; ADOLESCENT; ANKYLOSING SPONDYLITIS; ARTICLE; CHILD; FEMALE; HUMAN; HYPEROSTOSIS; MAJOR CLINICAL STUDY; MALE; OSTEITIS; PRIORITY JOURNAL; PUSTULOSIS; SAPHO SYNDROME; SYNOVITIS;

ACQUIRED HYPEROSTOSIS SYNDROME; ADOLESCENT; AGE DISTRIBUTION; AGE OF ONSET; BIOPSY; CHILD; CHILD, PRESCHOOL; DIAGNOSIS, DIFFERENTIAL; FEMALE; FOLLOW-UP STUDIES; HUMANS; MALE; PAIN; SEX DISTRIBUTION;

EID: 0033914189     PISSN: 03406199     EISSN: None     Source Type: Journal    
DOI: 10.1007/s004310000500     Document Type: Article

References (94)

1. Abril JC, Castillo F, Loewinson AF, Rivas C, Bernacer M (1994) Chronic recurrent multifocal osteomyelitis after acute lymphoblastic leukaemia. Int Orthop 18: 126-128
2. Azouk EM, Jurik AG, Bernard C (1998) Sternocostoclavicular hyperostosis in children: A report of eight cases. AJR 171: 461-466
3. Benhamou C (1988) Le syndrome synovite-acné-pustulosehyperostose-ostéite (SAPHO). Ann Dermatol Venereol 115: 613-618
4. Benhamou CL, Chamot AM, Kahn MF (1988) Synovitis-acnepustolosis hyperostosis-osteomyelitis syndrome (Sapho). A new syndrome among the spondyloarthropathies? Clin Exp Rheumatol 6: 109-112
5. Beraneck L, Kaplan G, Girardet JP (1990) Ostéite chronique récurrente multifocale. Evolution sur 12 ans. Rapport avec le SAPHO. Rev Rhum 57: 473-475
6. Björkstén B, Boquist L (1980) Histopathological aspects of chronic recurrent multifocal osteomyelitis. J Bone Joint Surg Am 62: 376-380
7. Björkstén B, Gustavson KH, Eriksson B, Lindholm A, Nordström S (1978) Chronic recurrent multifocal osteomyelitis and pustulosis palmoplantaris. J Pediatr 93: 227-231
8. Boutin RD, Resnick D (1998) The SAPHO syndrome: An evolving concept for unifying several idiopathic disorders of bone and skin. AJR 170: 585-591
9. Brand CU, Yawalkar N, Ballmer-Weber B, Braathen LR (1996) Pustulosis palmoplantaris associated with chronic recurrent multifocal osteomyelitis of the mandible. Br J Dermatol 134: 977-979
10. Brown T, Wilkinson RH (1988) Chronic recurrent multifocal osteomyelitis. Radiology 166: 493-496
11. Burgos-Vargas R (1993) Spondyloarthropathies and psoriatic arthritis in children. Curr Opin Rheumatol 5: 634-643
12. Byrd L, Grossmann M, Potter M, Shen-Ong GL (1991) Chronic multifocal osteomyelitis, a new recessive mutation on chromosome 18 of the mouse. Genomics 11: 794-798
13. Carr AJ, Cole WG, Roberton DM, Chow CW (1993) Chronic multifocal osteomyelitis. J Bone Joint Surg Br 75: 582-591
14. Chamot AM, Benhamou CL, Kahn MF, Beranek L, Kaplan G, Prost A (1987) Le syndrome acné pustulose hyperostose ostéite (SAPHO). Résultats d'une enquête nationale - 85 observations. Rev Rhum 54: 187-196
15. Cuende E, Gutiérrez MA, Paniagua G, Feito C, Gonzalez M, Sánchez J (1995) Chronic recurrent multifocal osteomyelitis: report of a case with epiphyseal and metaphyseal involvement. Clin Exp Rheumatol 13: 251-253
16. Cyrlak D, Pais MJ (1986) Chronic recurrent multifocal osteomyelitis. Skeletal Radiol 15: 32-39
17. Dawson JS, Webb JK, Preston BJ (1994) Case report: chronic recurrent multifocal osteomyelitis with magnetic resonance imaging. Clin Radiol 49: 133-136
18. Demharter J, Bohndorf K, Michl W, Vogt H (1997) Chronic recurrent multifocal osteomyelitis: a radiological and clinical investigation of five cases. Skeletal Radiol 26: 579-588
19. Dougados M, Van der Linden S, Juhlin R, Huitfeldt B, Amor B, Calin A, Cats A, Dijkmans B, Olivieri I, Pasero G, Veys E, Zeidler H (1991) The european spondyloarthropathy study group: preliminary criteria for the classification of spondyloarthropathy. Arthritis Rheum 34: 1218-1827
20. Flygare L, Norderyd J, Kubista J, Ohlsson J, Vallö-Christiansen J, Magnusson B (1997) Chronic recurrent multifocal osteomyelitis involving both jaws: report of a case including magnetic resonance correlation. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 83: 300-305
21. Gallagher KT, Roberts RL, MacFarlane JA, Stiehm ER (1997) Treatment of chronic recurrent multifocal osteomyelitis with interferon gamma. J Pediatr 131: 470-472
22. Gamble JG, Rinsky LA (1986) Chronic recurrent multifocal osteomyelitis: a distinct clinical entity. J Pediatr Orthop 6: 579-584
23. García-Marín F, Irarte-Ortabe JI, Reychler H (1996) Chronic diffuse sclerosing osteomyelitis of the mandible or mandibular location of S.A.P.H.O. Syndrome. Acta Stomatol Belg 99: 65-71
24. Giedion A, Holthusen W, Masel LF, Vischer D (1972) Subacute and chronic "symmetrical" osteomyelitis. Ann Radiol 15: 329-342
25. Girschick HJ, Krauspe R, Tschammler A, Huppertz HI (1998) Chronic recurrent osteomyelitis with clavicular involvement in children: diagnostic value of different imaging techniques and therapy with non-steroidal anti-inflammatory drugs. Eur J Pediatr 157: 28-33
26. Godette GA, Murray DP, Gruel CR, Leonard JC (1992) Chronic recurrent multifocal osteomyelitis. Orthopedics 15: 520-521, 525-526
27. Gustavson KH, Wilbrand HF (1974) Chronic symmetric osteomyelitis. Report of a case. Acta Radiol 15: 551-557
28. Gutzmer R, Herbst RA, Kapp A, Weiss J (1997) Das SAPHO-Syndrom. Fallbeschreibung von drei Patienten mit Akne conglobata und osteoartikulären Symptomen. Hautarzt 48: 186-190
29. Hatem SF, Petersilge CA, Park JK (1997) Musculoskeletal case of the day. Chronic recurrent multifocal osteomyelitis (CRMO). AJR 169: 285, 289-291
30. Hoeffel JC, Kopf S, Chateil JF, Mainard L, Chastagner P (1997) Les ostéites métaphysaires inflammatoires non suppurées. A propos de 4 observations. Ann Pédiatr 44: 376-390
31. Huaux JP, Esselinckx W, Rombouts JJ, Maldague B, Malghem J, Devogelaer JP, Nagant de Deuxchaisnes C (1988) Pustulotic arthroosteitis and chronic recurrent multifocal osteomyelitis in children. Report of three cases. J Rheumatol 15: 95-100
32. Huaux JP, Maldague B, Malghem J, Meunier H, Noël H, Nagant de Deuxchaisnes C (1986) Pustulotic arthro-osteitis and related disorders in children and adults. A report of 7 cases. J Belge Radiol 69: 345-354
33. Huaux JP, Malghem J, Rombouts JJ, Esselinckx W, Lokietek JC, Noël H, Nagant de Deuxchaisnes C (1987) Ostéomyélite récidivante multifocale chronique de l'enfant et pustulose palmo-plantaire. A propos d'un nouveau cas. Rev Rhum Mal Osteoartic 54: 403-405
34. Hummell DS, Andersen SJ, Wright PF, Cassell GH, Waites KB (1987) Chronic recurrent multifocal osteomyelitis: are mycoplasmas involved? N Engl J Med 317: 510-511
35. Ivker RA, Grin-Jorgensen CM, Vega VK, Hoss DM, Grant-Kels JM (1993) Infantile generalized pustular psoriasis associated with lytic lesions of the bone. Pediatr Dermatol 10: 277-282
36. Jana H, Pavel K (1993) The SAPHO syndrome in a 16-year-old boy: coincidence of acne conglobata and osteoarthritis. J Adolesc Health 14: 120-123
37. Jurik AG, Egund N (1997) MRI in chronic recurrent multifocal osteomyelitis. Skeletal Radiol 26: 230-238
38. Jurik AG, Moller BN (1986) Inflammatory hyperostosis and sclerosis of the clavicle. Skeletal Radiol 15: 284-290
39. Jurik AG, Moller BN (1987) Chronic sclerosing osteomyelitis of the clavicle. A manifestation of chronic recurrent multifocal steomyelitis. Arch Orthop Trauma Surg 106: 144-151
40. Jurik AG, Helmig O, Ternowitz T, Moller BN (1988) Chronic recurrent multifocal osteomyelitis: a follow-up study. J Pediatr Orthop 8: 49-58
41. Jurik AG, Moller SH, Mosekilde L (1988) Chronic sclerosing osteomyelitis of the iliac bone. Etiological possibilities. Skeletal Radiol 17: 114-118
42. Kahn MF (1993) Psoriatic arthritis and synovitis, acne, pustulosis, hyperostosis, and osteitis syndrome. Curr Opin Rheumatol 5: 428-435
43. Kahn MF (1995) Why the "SAPHO" syndrome? J Rheumatol 22: 2017-2019
44. Kahn MF, Chamot AM (1992) Sapho syndrome. Rheum Dis Clin North Am 18: 225-246
45. Kahn MF, Kahn MA (1994) The SAPHO syndrome. Baillères Clin Rheumatol 8: 333-362
46. Kahn MF, Hayem F, Hayem G, Grossin M (1994) Is diffuse sclerosing osteomyelitis of the mandible part of the synovitis, acne, pustulosis, hyperostosis, osteitis (SAPHO) syndrome? Analysis of seven cases. Oral Surg Oral Med Oral Pathol Radiol Endod 78: 594-598
47. Kerem E, Manson D, Laxer RM, Levison H, Reilly BJ (1989) Pulmonary association in a case of chronic recurrent multifocal osteomyelitis. Pediatr Pulmonol 7: 55-58
48. King SM, Laxer RM, Manson D, Gold R (1987) Chronic recurrent multifocal osteomyelitis: a noninfectious inflammatory process. Pediatr Infect Dis J 6: 907-911
49. Konczaty H, Bourrillon A, Hayem F (1990) Le rhumatisme de l'acné conglobata. A propos d'une nouvelle observation, chez un garçon de treize ans. Ann Pédiatr 37: 231-234
50. Kozlowski K, Beluffi G, Feltham C, James M, Nespoli L, Tamaela L (1985) Multifocal, chronic osteomyelitis of unknown etiology. A further report. ROFO Fortschr Geb Rontgenstr Nuklearmed 142: 440-446
51. Laxer RM, Shore AD, Manson D, King S, Silverman ED, Wilmot DM (1988) Chronic recurrent multifocal osteomyelitis and psoriasis-a report of a new association and review of related disorders. Semin Arthritis Rheum 17: 260-270
52. Leech S (1998) Molecular mimicry in autoimmune disease. Arch Dis Child 79: 448-451
53. Machiels F, Seynaeve P, Lagey C, Mortelmans LL (1992) Chronic recurrent multifocal osteomyelitis with MR correlation: a case report. Pediatr Radiol 22: 535-536
54. Mackay IR, Gershwin ME (1997) The nature of autoimmune disease. Semin Liver Dis 17: 3-11
55. Majeed SA (1994) Chronic recurrent multifocal osteomyelitis associated with tumoral calcinosis. J Bone Joint Surg Br 76: 325-327
56. Majeed HA, Kalaawi M, Mohanty D, Teebi AS, Tunjekar MF, Al-Gharbawy F, Majeed SA, Al-Gazzar AH (1989) Congenital dyserythtropoietic anemia and chronic recurrent multifocal osteomyelitis in three related children and the association with Sweet syndrome in two siblings. J Pediatr 115: 730-734
57. Manson D, Wilmot DM, King S, Laxer RM (1989) Physeal involvement in chronic recurrent multifocal osteomyelitis. Pediatr Radiol 20: 76-79
58. Martin JC, Desoysa R, O'Sullivan MM, Silverstone E, Williams H (1996) Chronic recurrent multifocal osteomyelitis: spinal involvement and radiological appearances. Br J Rheumatol 35: 1019-1021
59. Matsuoka Y, Okada N, Yoshikawa K (1993) Familial cases of psoriasis vulgaris and pustulosis palmaris et plantaris. J Dermatol 20: 308-310
60. Meller Y, Yagupsky P, Elitsur Y, Inbar-Ianay I, Bar-Ziv J (1984) Chronic multifocal symmetrical osteomyelitis. Report of two cases in bedouin infants. Am J Dis Child 138: 349-351
61. Meyer zu Reckendorf G, Milon E, Pous JG (1996) Chronic recurrent multifocal osteomyelitis (C. R. M. O.): a case report and review of literature. Eur J Pediatr Surg 6: 312-315
62. Mortensson W, Edeburn G, Fries M, Nilsson R (1988) Chronic recurrent multifocal osteomyelitis in children. A roentgenologic and scintigraphic investigation. Acta Radiol 29: 565-570
63. Murray SD, Douglas KK (1984) Chronic recurrent multifocal osteomyelitis. J Bone Joint Surg Am 66: 1110-1112
64. Paller AS, Pachman L, Rich K, Esterly NB, Gonzalez-Crussi F (1985) Pustulosis palmaris et plantaris: its association with chronic recurrent multifocal osteomyelitis. J Am Acad Dermatol 12: 927-930
65. Pelkonen P, Ryöppy S, Jääskeläinen J, Rapola J, Repo H, Kaitila I (1988) Chronic osteomyelitislike disease with negative bacterial cultures. Am J Dis Child 142: 1167-1173
66. Péré P, Terver-Gillet MN, Gillet P, Schmutz JL, Gaucher A (1993) Dermatoses et enthésiopathies. Ann Dermatol Venereol 120: 321-326
67. Pompei G, Aldrovandi S, Raspa V (1990) Osteomielite subacuta multifocale ricorrente in età pediatrica. Radiol Med 79: 549-552
68. Prieur AM (1998) Spondyloarthropathies in childhood. Bailières Clin Rheumatol 12: 287-307
69. Probst FP (1984) Chronic recurrent multifocal osteomyelitis. Case report and overview as a contribution to the knowledge about the disease. Radiologe 24: 24-30
70. Prose NS, Fahrner LJ, Miller CR, Layfield L (1994) Pustular psoriasis with chronic recurrent multifocal osteomyelitis and spontaneous fractures. J Am Acad Dermatol 31:376-379
71. Quelquejay C, Job-Deslandre C, Hamidou A, Bensoman A, Adamsbaum C (1997) Ostéite chronique multifocale récurrente de l'enfant. J Radiol 78: 115-121
72. Ravelli A, Marseglia GL, Viola S, Ruperto N, Martini A (1995) Chronic recurrent multifocal osteomyelitis with unusual features. Acta Pediatr 84: 222-225
73. Reuland P, Feine U, Handgretinger R, Kaiserling E, Klingebiel T, Niethammer D (1992) Case report 756. Skeletal Radiol 21: 478-481
74. Rondeleux E, Petrus M, Ibanez MH, Netter JC, Rhabbour M (1994) Association d'un rhumatisme psoriasique et d'une ostéite multifocale inflammatoire. Ann Pédiatr 41: 569-572
75. Rosenberg ZS, Shankman S, Klein M, Lehman W (1988) Chronic recurrent multifocal osteomyelitis. AJR 151: 142-144
76. Rydén C, Yacoub A, Hirsch G, Wendel M, Oldberg A, Ljungh A (1990) Binding of bone sialoprotein to Staphylococcus epidermidis isolated from a patient with chronic recurrent multifocal osteomyelitis. J Infect Dis 161: 814-815
77. Saint-Martin C, Kurelovic I, Durckel J, Soler C, Geoffray A (1997) Chronic recurrent multifocal osteomyelitis. A diagnosis to be called to mind. J Radiol 78: 111-114
78. Schenk JP, Limberg B, Grauer A, Kauffmann G (1998) Chronisch rekurrierende multifokale Osteomyelitis (CRMO). Diaphysärer Befall mit progredienter Hyperostose. Fortschr Röntgenstr 168: 624-627
79. Schilling F (1998) Die chronisch rekurrierende multifokale Osteomyelitis (CRMO). Fortschr Röntgenstr 168: 115-127
80. Schultz C, Holterhus PM, Seidel A, Jonas S, Barthel M, Kruse K, Bucksy P (1999) Chronic recurrent multifocal osteomyelitis in children. Pediatr Infect Dis J 18: 1008-1013
81. Schuster T, Bielek J, Dietz HG, Belohradsky BH (1996) Chronic recurrent multifocal osteomyelitis (CRMO). Eur J Pediatr Surg 6: 45-51
82. Solheim LF, Paus B, Liverud K, Stoen E (1980) Chronic recurrent multifocal osteomyelitis. A new clinical-radiological syndrome. Acta Orthop Scand 51: 37-41
83. Spina V, Mussini C, Mascia MT, Baldini A, Cerofolini E (1989) Osteomielite cronica ricorrente multifocale. Considerazioni clinico-radiologiche. Radiol Med 78: 246-249
84. Stanton RP, Lopez-Sosa FH, Doidge R (1993) Chronic recurrent multifocal osteomyelitis. Orthop Rev 22: 229-233
85. Starinsky R (1991) Multifocal chronic osteomyelitis with exuberant periosteal formation. Pediatr Radiol 21: 455-456
86. Sundaram M, McDonald D, Engel E, Rotman M, Siegfried EC (1996) Chronic recurrent multifocal osteomyelitis: an evolving clinical and radiological spectrum. Skeletal Radiol 25: 333-336
87. Tan BS, Nayanar V, Mansberg R, Murray IP, Rossleigh MA (1996) Two cases of chronic recurrent multifocal osteomyelitis: radiological and scintigraphic findings. Australas Radiol 40: 437-441
88. Toussirot E, Dupond JL, Wendling D (1997) Spondylodiscitis in SAPHO syndrome. A series of eight cases. Ann Rheum Dis 56: 52-58
89. Trotta E, La Corte R, Bajocchi G, Manicardi S (1990) Hyperostosis and multifocal osteitis: a purely rheumatological subset of the SAPHO syndrome. Clin Exp Rheumatol 8: 401-405
90. Uhl M, Leichsenring M, Krempien B (1995) Chronisch rezidivierende multifokale Osteomyelitis. Rofo Fortschr Geb Röntgenstr Neuen Bildgeb Verfahr 162: 527-530
91. Van Howe RS, Starshak RJ, Chusid MJ (1989) Chronic, recurrent multifocal osteomyelitis. Case report and review of the literature. Clin Pediatr 28: 54-59
92. Vermylen C, Scheiff JM, Rodhain J, Ninane J, Cornu G (1986) A variant of the congenital dyserythropoietic anaemia type II with structural abnormalities in the granulocytic series. Eur J Pediatr 145: 232-235
93. Wiener MD, Newbold RG, Merten DF (1986) Chronic recurrent multifocal osteomyelitis (case report). AJR 147: 87-88
94. Yu L, Kasser JR, O'Rourke E, Kozakewich H (1989) Chronic recurrent multifocal osteomyelitis. Association with vertebra plana. J Bone Joint Surg Am 71: 105-112