Dangerous signals from E. coli toxin

Nature Medicine

Volumn 6, Issue 7, 2000, Pages 741-742

  Ludwig, Albrecht ^a   Goebel, Werner ^b  

^a GOETHE UNIVERSITY   (Germany)

^b UNIVERSITY OF WÜRZBURG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

HEMOLYSIN;

AMINO ACID SEQUENCE; BACTERIAL VIRULENCE; ESCHERICHIA COLI; NONHUMAN; PHOSPHOINOSITIDE METABOLISM; PRIORITY JOURNAL; SHORT SURVEY; TOXIN ANALYSIS;

BACTERIAL PROTEINS; BACTERIAL TOXINS; CALCIUM SIGNALING; ESCHERICHIA COLI; ESCHERICHIA COLI PROTEINS; GENE EXPRESSION; HEMOLYSIN PROTEINS; MODELS, MOLECULAR; SIGNAL TRANSDUCTION; URINARY TRACT INFECTIONS;

BACTERIA (MICROORGANISMS); ESCHERICHIA COLI;

EID: 0033914179     PISSN: 10788956     EISSN: None     Source Type: Journal    
DOI: 10.1038/77456     Document Type: Short Survey

References (11)

1. nd ed. (eds. Alouf, J.E. & Freer, J.H.) 330-348 (Academic Press, London, 1999).
2. Uhlen, P. et al. α-Hemolysin of uropathogenic E. coli: an inducer of calcium oscillations in renal epithelial cells. Nature 405, 694-697 (2000).
3. Bhakdi, S. et al. Potent leukocidal action of Escherichia coli hemolysin mediated by permeabilization of target cell membranes. J. Exp. Med. 169, 737-754 (1989).
4. Bhakdi, S., Muhly, M., Korom, S. & Schmidt, G. Effects of Escherichia coli hemolysin on human monocytes. Cytocidal action and stimulation of interleukin 1 release. J. Clin. Invest. 85, 1746-1753 (1990).
5. Grimminger, F., Sibelius, U., Bhakdi, S., Suttorp, N. & Seeger, W. Escherichia coli hemolysin is a potent inductor of phosphoinositide hydrolysis and related metabolic responses in human neutrophils. J. Clin. Invest. 88, 1531-1539 (1991).
6. Grimminger, F. et al. Human endothelial cell activation and mediator release in response to the bacterial exotoxins Escherichia coli hemolysin and Staphylococcal α-toxin. J. Immunol. 159, 1909-1916 (1997).
7. Berridge, M.J. Elementary and global aspects of calcium signalling. J. Physiol. 499, 291-306 (1997).
8. Berridge, M.J., Bootman, M.D. & Lipp, P. Calcium - A life and death signal. Nature 395, 645-648 (1998).
9. 2+ response amplitude and duration. Nature 386, 855-858 (1997).
10. Dolmetsch, R.E., Xu, K. & Lewis, R.S. Calcium oscillations increase the efficiency and specificity of gene expression. Nature 392, 933-936 (1998).
11. Benz, R., Schmid, A., Wagner, W. & Goebel, W. Pore formation by the Escherichia coli hemolysin: evidence tor an association-dissociation equilibrium of the pore-forming aggregates. Infect. Immun. 57, 887-895 (1989).