Regulation of α1-adrenoceptor on rat hepatocyte apoptosis induced by D-galactosamine and lipopolysaccharide

Acta Pharmacologica Sinica

Volumn 21, Issue 7, 2000, Pages 627-632

  Zhang, Ya Shong ^a,b   Tu, Zhi Guang ^a  

^a CHONGQING MEDICAL UNIVERSITY   (China)

^b GUANGZHOU GENERAL HOSPITAL OF GUANGZHOU MILITARY COMMAND   (China)

Author keywords

Adrenergic receptors; Apoptosis; Calcium; Lipopolysaccharides; Phospholipases A; Prazosin; Tumor necrosis factor

Indexed keywords

ALANINE AMINOTRANSFERASE; ALPHA 1 ADRENERGIC RECEPTOR; CALCIUM; GALACTOSAMINE; LIPOPOLYSACCHARIDE; PHOSPHOLIPASE A2; PRAZOSIN; TUMOR NECROSIS FACTOR ALPHA;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CALCIUM CELL LEVEL; CONTROLLED STUDY; LIVER CELL; NONHUMAN; PROTEIN EXPRESSION; RAT; SIGNAL TRANSDUCTION;

ADRENERGIC ALPHA-ANTAGONISTS; ANIMALS; APOPTOSIS; CALCIUM; GALACTOSAMINE; HEPATOCYTES; LIPOPOLYSACCHARIDES; MALE; PHOSPHOLIPASES A; PRAZOSIN; RATS; RATS, WISTAR; RECEPTORS, ADRENERGIC, ALPHA-1; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0033912314     PISSN: 02539756     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (11)

1. Thomas CE, Reed DJ. Current status of calcium in hepatocellular injury. Hepatology 1989; 10: 375-84.
2. Agarwal ML, Larkin LE, Zaidi SIA, Mukhtar H, Oleinick ML. Phospholipase activation triggers apoptosis in photosensitized mouse lymphoma cells. Cancer Res 1993; 53: 5897-902.
3. Xu Y, Tu ZG, Kang GF. A simplifying density-gradient centrifugation procedure to purify hepatocyte. Acta Univ Sci Med Chongqing 1999; 24: 178-9.
4. 2+ level of the isolated rat hepatocytes with fluorescent probe fura-2/ AM. Acta Univ Sci Med Chongqing 1997; 22: 305-7.
5. 2 in human polymorphonuclear leukocytes. Biochem Biophys Acta 1986; 879: 149-56.
6. McConkey DJ, Orrenius S. Signal transduction pathways to apoptosis. Trends Cell Biol 1991; 4: 370-5.
7. Bygrave FL, Benedetti A. Calcium: its modulation in liver by cross-talk between the actions of glucagon and calcium-mobilizing agonists. Biochem J 1993; 296: 1-4.
8. 2 activity. J Biol Chem 1987; 262: 11761-70.
9. Morikawa A, Sugiyama T, Kato Y, Koide N, Jiang GZ, Takahashi K, et al. Apoptotic cell death in the response of D-Galactosamine-sensitized mice to lipopolysaccharide as an experimental endotoxic shock model. Infect Immun 1996; 61: 734-8.
10. Van der poll T, Jansen J, Endert E, Sauerwein HP, Van Deventer SJH. Noradrenaline inhibits lipopolysaccharide-induced tumor necrosis factor and interleukin 6 production in human whole blood. Infect Immun 1994 ; 62: 2016-50.
11. 2 levels as a mechanism by which the p70 TNF and p75 NGF receptors enhance apoptosis. FEBS Lett 1996; 379: 77-81.