A new locus for generalized epilepsy with febrile seizures plus maps to chromosome 2

American Journal of Human Genetics

Volumn 66, Issue 2, 2000, Pages 698-701

  Lopes Cendes, I ^a,b,f   Scheffer, I E ^e   Berkovic, S F ^e   Rousseau, M ^a   Andermann, E ^b,c,d   Rouleau, G A ^a,c,d  

^a MONTREAL GENERAL HOSPITAL   (Canada)

^b MCGILL UNIVERSITY   (Canada)

^c Dept of Neurology and Neurosurgery ^*  (Canada)

^d MCGILL UNIVERSITY   (Canada)

^e UNIVERSITY OF MELBOURNE   (Australia)

^f UNIVERSITY OF CAMPINAS   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; CHROMOSOME 2Q; CLINICAL ARTICLE; FEBRILE CONVULSION; GENE LOCUS; GENE MAPPING; GENERALIZED EPILEPSY; GENETIC PREDISPOSITION; GENOTYPE; HUMAN; PRIORITY JOURNAL;

EID: 0033912108     PISSN: 00029297     EISSN: None     Source Type: Journal    
DOI: 10.1086/302768     Document Type: Article

References (18)

1. A receptor form ion channels with properties of the native receptor. Science 242: 577-579
2. Baulac S, Gourfinkel-An I, Picard F, Rosenberg-Bourgin M, Prud'homme J-F, Baulac M, Brice A, et al (1999) A second locus for familial generalized epilepsy with febrile seizures plus maps to chromosome 2q21-q33. Am J Hum Genet 65: 1078-1085
3. Berkovic SF, Scheffer IE (1999) Genetics of the epilepsies. Curr Opin Neurol 12:177-182
4. Bievert C, Schoeder BC, Kubisch C, Berkovic SF, Propping P, Jentsch TJ, Steinlein OK (1998) A potassium channel mutation in neonatal human epilepsy. Science 279:403-406
5. Bu DF, Tobin AJ (1994) The exon-intron organization of the genes (GAD1 and GAD2) encoding two human glutamate decarboxylases (GAD67 and GAD65) suggests that they derive from a common ancestral GAD. Genomics 21:222-228
6. Commission on Classification and Terminology of the International League against Epilepsy (1981) Proposal for revised clinical and electroencephalographic classification of epileptic seizures. Epilepsia 22:489-501
7. Gyapay G, Morissette J, Vignal A, Dib C, Fizames C, Millasseau P, Marc S, et al (1994) The 1993-94 Généthon human genetic linkage map. Nat Genet 7:246-339
8. Hauser WA, Annegers JF, Kurland LT (1993) Incidence of epilepsy and unprovoked seizures in Rochester, Minnesota: 1935-1984. Epilepsia 34:453-468
9. Lathrop GM, Lalouel JM (1984) Easy calculations of LOD scores and genetic risks on small computers. Am J Hum Genet 36:460-465
10. Lopes-Cendes I, Scheffer IE, Berkovic SF, Rousseau M, Andermann E, Rouleau GA (1996) Mapping a locus for idiopathic generalized epilepsy in a large multiplex family. Epilepsia 37 Suppl 5:127
11. Moulard B, Guipponi M, Chaigne D, Mouthon D, Buresi C, Malafosse A (1999) Identification of a new locus for generalized epilepsy with febrile seizures plus (GEFS+) on chromosome 2q24-q33. Am J Hum Genet 65:1396-1400
12. Peiffer A, Thompson J, Charlier C, Otterud B, Varvil T, Pappas C, Barnitz C, et al (1999) A locus for febrile seizures (FEB3) maps to chromosome 2q23-24. Ann Neurol 46:671-678
13. Sambrook J, Fritsch EF, Maniatis T (eds) (1989) Molecular cloning: a laboratory manual, 2d ed. Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, pp E.3-E.4
14. Scheffer IE, Berkovic SF (1997) Generalized epilepsy with febrile seizures plus: a genetic disorder with heterogeneous clinical phenotypes. Brain 120:479-490
15. Singh NA, Charlier C, Stauffer D, DuPont BR, Leach RJ, Melis R, Ronen GM, et al (1998) A novel potassium channel gene, KCNQ2, is mutated in an inherited epilepsy of newborns. Nat Genet 18:25-29
16. Singh R, Scheffer IE, Crossland K, Berkovic SF (1999) Generalized epilepsy with febrile seizures plus (GEFS+): a common, childhood-onset, genetic epilepsy syndrome. Ann Neurol 45:75-81
17. Steinlein OK, Mulley JC, Propping P, Wallace RH, Phillips HA, Sutherland GR, Scheffer IE, et al (1995) A missense mutation in the neuronal nicotinic acetylcholine receptor α4 subunit is associated with autosomal dominant nocturnal frontal lobe epilepsy. Nat Genet 11:201-203
18. Wallace RH, Wang DW, Sing R, Scheffer IE, George AI. Jr , Phillips HA, Saar K, et al (1998) Febrile seizures and generalized epilepsy associated with a mutation in the Na +-channel β1 subunit gene SCN1B. Nat Genet 19:366-370