Endocrine dysfunctions in patients treated for brain tumors: Incidence and guidelines for management

Journal of Neuro-Oncology

Volumn 47, Issue 1, 2000, Pages 85-92

  Brandes, Alba Ariela ^a   Pasetto, Lara Maria ^a   Lumachi, Franco ^a   Monfardini, Silvio ^a  

^a UNIVERSITY HOSPITAL OF PADOVA   (Italy)

Author keywords

Brain tumors; Endocrine dysfunction; Late effects; Long term survivors; Review

Indexed keywords

ANTINEOPLASTIC AGENT; ARGININE; BROMOCRIPTINE; CABERGOLINE; CLONIDINE; CONJUGATED ESTROGEN; ETHINYLESTRADIOL; GONADORELIN AGONIST; HORMONE DERIVATIVE; LEUPRORELIN; LEVODOPA; LEVOTHYROXINE; LOMUSTINE; PROCARBAZINE; RECOMBINANT GROWTH HORMONE; SOMATOMEDIN C; SOMATREM; TESTOSTERONE ENANTATE; VINCRISTINE;

BRAIN TUMOR; CLINICAL TRIAL; ENDOCRINE DISEASE; FOLLOW UP; GONADAL DISEASE; GROWTH HORMONE DEFICIENCY; HORMONE SUBSTITUTION; HUMAN; HYPERPROLACTINEMIA; HYPOTHALAMUS HYPOPHYSIS SYSTEM; HYPOTHYROIDISM; PRACTICE GUIDELINE; QUALITY OF LIFE; RADIATION DOSE DISTRIBUTION; REVIEW; TUMOR RECURRENCE;

BRAIN NEOPLASMS; ENDOCRINE SYSTEM DISEASES; HUMANS; INCIDENCE; PRACTICE GUIDELINES;

EID: 0033910172     PISSN: 0167594X     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1006471405435     Document Type: Review

References (37)

1. Littley MD, Shalet SM, Beradwell CG: Radiation induced hypopituitarism is dose-dependent. Clin Endocrinol 31: 363, 1989
2. Taphoorn MJB, Heimains JJ, Karim F: Endocrine functions in long-term survivors of low-grade supratentorial glioma treated with radiotherapy. J Neuro-Oncol 25: 97-102, 1995
3. Lam KSL, Tse VKC, Yeung RTT: Effects of cranial irradiation on hypothalamic-pituitary function a 5 year longitudinal study in patients with nasopharyngeal carcinoma. J Med 78: 165-176, 1991
4. Constine LS, Woolf PD, Rubin P: Hypothalamic-pituitary dysfunction after radiation for brain tumors. N Engl J Med 328: 87-94, 1993
5. Duffner PK, Cohen ME, Gilani BB: Long-term effect of cranial irradiation on endocrine function in children with brain tumors. Cancer 56: 2189-2193, 1985
6. Shalet SM: Radiation and pituitary dysfunction. New Engl J Med 14: 131-133, 1993
7. Lam KSL, Wang C, Ling N: Hypothalamic hypopituitarism following cranial irradiation for nasopharyngeal carcinoma. Clin Endocrinol 24: 643-651, 1986
8. Arnold A, Bailey P, Laughlin JS: Effect of betatron radiations on the brain of primates. Neurology 4: 165-178, 1984
9. Kelly KH, Felsted ET, Brown RF, Shimkin MB: Irradiation of the normal human hypophysis in malignancy: report of three cases receiving 8, 1-10 tissue dose to the pituitary gland. J Nat Cancer Inst 11: 967-975, 1951
10. Constine LS, Rubin P, Lush C: Hyperprolactinemia and hypothyroidism following cytotoxic therapy for central nervous system malignancies. J Clin Oncol 11(5): 1841-1851, 1987
11. Heikens J, Michiels EMC, Behrendt H et al.: Long-term neuro-endocrine sequelae after treatment for childhood medulloblastoma. Eur J Cancer 34(10): 592-597, 1998
12. Abayomi, Sadegni-Nejad A: The incidence of late endocrine dysfunction following irradiation for childhood medulloblastoma. Int J Radiat Oncol Biol Phys 12(6): 945-948, 1986
13. Shalet SM, Beardwell CG, Pearson D: Endocrine morbidity in adults treated with cerebral irradiation for brain tumors during childhood. Acta Endocrinol 84: 673-680, 1977
14. Shalet SM, Beradwell CG, Pearson D: Pituitary function after treatment of intracranial tumors in children. Lancet: 104-107, 1975
15. Harrop JS, Davies TJ, Marks V: Hypothalamic-pituitary function following successful treatment of intracranial tumors. Clin Endocrinol 5: 313-321, 1976
16. Ogilvy-Stuart AL, Clayton PE, Shalet SM: Cranial irradiation and early puberty. J Clin Endocrinol Metab 78: 1282-1286, 1994
17. Clayton PE, Shalet SM: Dose dependency of time of onset of radiation-induced growth hormone deficiency. J Ped 118: 226-228, 1991
18. Shalet SM, Beardwell CG, MacFarlane A: Endocrine morbidity in adults treated with cerebral irradiation for brain tumors during childhood. Acta Endocrinol 84: 673-680, 1997
19. Onoyama Y, Sakamoto T: Radiation therapy of brain tumors in children. Radiology 115: 687-693, 1975
20. Ahmed SR, Shalet SM: Hypothalamic growth hormone releasing factor deficiency following cranial irradiation. Clin Endocrinol 21: 483-488, 1984
21. Bamford FN, Berdwell CG: Residual disabilities in children treated for intracranial space-occupying lesions. Cancer 37: 1149-1151, 1976
22. Hoffman DM, O Sullivan AJ, Baxter RC et al.: Diagnosis of growth-hormone deficiency in adults. Lancet 343: 1064-1068, 1994
23. Livesey EA, Hindmarsh PC, Britton J: Endocrine disorders following treatment of childhood brain tumors. Br J Cancer 61: 622-625, 1990
24. Blacklay A, Grossman A, Besser GM: Cranial irradiation for cerebral and nasopharyngeal tumours in children: evidence for the production of a hypothalamic defect in growth hormone release. J Endocrinol 108: 25-29, 1986
25. Backlay A, Baser GM: Cranial irradiation for cerebral and nasopharyngeal tumors in children: defect in growth hormone release. J Endocrinol 108: 25-29, 1986
26. Brauner R, Rappaport R: Precocious puberty secondary to cranial irradiation for tumors distant from the hypothalamic-pituitary area. Horm Res 22: 78-82, 1985
27. Kaplan SA: Growth and growth hormone: disorders of the anterior pituitary. In: Kaplan SA (ed) Clinical Pediatric Endocrinology. Philadelphia, 1990, pp 1-63
28. Meacham LR, Ghim TT, Crocker IR: Systematic approach for detection of endocrine disorders in children treated for brain tumors. Med Pediatr Oncol 29: 86-91, 1997
29. Clayton PE, Gattamaneni HR, Shalet SM, Price DA: Does growth hormone cause relapse of brain tumors. Lancet 711-713, 1987
30. Oberfield SE, Skaler C, Allen J: Thyroid and gonadal function and growth in long-term survivors of medulloblastoma/PNET. In: Green DM, D'Angiò GJ (eds) Late Effects of Treatment for Childhood Cancer. Wiley-Liss, New York, 1992, pp 55-62
31. Lam KSL, Tse VKC, Wang C, Yeung RTT, Ma JTC, Ho JHC: Early effects of cranial irradiation on hypothalamic-pituitary function. J Clin Endocrinol Metab 64: 418, 1987
32. Rappaport R, Brauner R, Cyernichow P: Effect of hypothalamic and pituitary irradiation on puberal development in children with cranial tumors. J Clin Endocrinol 54: 1164, 1982
33. Shalet SM, Clayton PE, Price DA: Growth and pituitary function in children treated for brain tumours or acute lymphoblastic leukemia. Horm Res 30: 53, 1988
34. Mauras N, Sabio H, Rogol QD: Neuroendocrine function in survivors of childhood acute lymphocytic leukemia and non-Hodgkin lymphoma: a study of pulsatile growth hormone and gonadotropin secretion. Am J Ped Haematol Oncol 10: 9, 1988
35. Rappaport R, Brauner R: Growth and endocrine disorders secondary to cranial irradiation. Pediatr Res 25: 561, 1989
36. Lannering B, Jansson C, Albertsson-Wikland K: Increased LH and FSH secretion after cranial irradiation in boys. Med Ped One 29: 280-287, 1997
37. Christiansen JS, Jorgensen JOL: Beneficial effects of GH replacement in adults. Acta Endocrinol 125: 7-13, 1991