Utility of Biochemical Systems Theory for the analysis of metabolic effects from low-dose chemical exposure

Risk Analysis

Volumn 20, Issue 3, 2000, Pages 393-402

  Voit, E O ^a  

^a MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

Author keywords

Biochemical Systems Theory; Chemical exposure; Dose response relationship; S system

Indexed keywords

ENVIRONMENTAL CHEMICAL;

ARTICLE; BIOCHEMISTRY; DOSE RESPONSE; ENVIRONMENTAL EXPOSURE; MATHEMATICAL MODEL; METABOLISM; RISK ASSESSMENT;

DOSE-RESPONSE RELATIONSHIP, DRUG; ENVIRONMENTAL HEALTH; ENVIRONMENTAL POLLUTANTS; HUMANS; METABOLISM; MODELS, BIOLOGICAL; RISK ASSESSMENT; SYSTEMS THEORY;

EID: 0033903296     PISSN: 02724332     EISSN: None     Source Type: Journal    
DOI: 10.1111/0272-4332.203038     Document Type: Article

References (41)

1. The linearized multistage model and the future of quantitative risk assessment
2. Biologically based, quantitative risk assessment of neurotoxicants
3. Toxicology and epidemiology of 1,3-butadiene
4. Role of oxidative stress in development of complications in diabetes
5. Biochemical systems analysis, I. Some mathematical properties of the rate law for the component enzymatic reactions
6. Biochemical systems analysis, II. The steady-state solutions for an n-pool system using a power-law approximation
7. Biochemical systems analysis, III. Dynamic solutions using a power-law approximation
8. Derivation of the linear-logistic model and Cox's proportional hazard model from a canonical system description
9. Accuracy of alternative representations for integrated biochemical systems
10. The tricarboxylic acid cycle in Dictyostelium discoideum
11. Comparative characterization of the fermentation pathway of Saccharomyces cerevisiae using biochemical systems theory and metabolic control analysis. Model validation and dynamic behavior
12. The role of canonical modeling as a unifying framework for ecological and human risk assessment
13. Bioeconomic dynamics of a fishery modeled as an S-system
14. GTP-dependent kinetic proofreading
15. Metabolic pathway characterization from transient response data obtained in situ: Parameter estimation in S-system models
16. Modelling approach to control of carbohydrate metabolism during citric acid accumulation by Aspergillus niger. I. Model definition and stability analysis
17. Application of biochemical systems theory to metabolism in human red blood cells
18. Flux-based estimation of parameters in S-systems
19. The use of canonical S-system modelling for condensation of complex dynamic models
20. Mathematical models of purine metabolism in man
21. Analysis of abnormalities in purine metabolism leading to gout and to neurological dysfunctions in man
22. Network regulation of the immune response: Alternative control points for suppressor modulation of effector lymphocytes
23. Subunit structure of regulator proteins influences the design of gene circuitry: Analysis of perfectly coupled and completely uncoupled circuits
24. Rules for coupled expression of regulator and effector genes in inducible circuits
25. Completely uncoupled and perfectly coupled gene expression in repressible systems
26. Concepts relating behaviour of biochemical systems to their underlying molecular properties
27. The behavior of intact biochemical control systems
28. Fundamental carcinogenic processes and their implications for low dose risk assessment
29. Cancer and ageing in mice and man
30. Comparison of alternative iso-effect curves in radiotherapy
31. Recasting nonlinear differential equations as S-systems: A canonical nonlinear form
32. Does any enzyme follow the Michaelis-Menten equation?
33. Critique of the enzymologist's test tube
34. Enzyme kinetics in vitro and in vivo: Michaelis-Menten revisited
35. Parameter sensitivity as a criterion for evaluating and comparing the performance of biochemical systems