Farnesyl-L-cysteine analogs block SAM-induced Parkinson's disease-like symptoms in rats

Pharmacology Biochemistry and Behavior

Volumn 66, Issue 4, 2000, Pages 841-849

  Lamango, Nazarius S ^a   Charlton, Clivel G ^a  

^a FLORIDA A AND M UNIVERSITY   (United States)

Author keywords

6 Hydroxydopamine; Abnormal posture; Amphetamine; Farnesylcysteine; Hypokinesia; Methylation; Parkinson's disease; Rigidity; S adenosylmethionine; Tremor

Indexed keywords

AMPHETAMINE; FARNESYLCYSTEINE; S ADENOSYLMETHIONINE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN HOMOGENATE; CONTROLLED STUDY; GEL FILTRATION CHROMATOGRAPHY; MALE; METHYLATION; MUSCLE RIGIDITY; NEUROTRANSMITTER RELEASE; NONHUMAN; PARKINSON DISEASE; PRIORITY JOURNAL; RAT; TREMOR;

AMPHETAMINE; ANIMALS; CENTRAL NERVOUS SYSTEM STIMULANTS; CHROMATOGRAPHY, GEL; CYSTEINE; FREEZE DRYING; MALE; METHYLATION; MOTOR ACTIVITY; NERVE TISSUE PROTEINS; OXIDOPAMINE; PARKINSON DISEASE, SECONDARY; RATS; RATS, SPRAGUE-DAWLEY; S-ADENOSYLMETHIONINE; STEREOTYPED BEHAVIOR; SYMPATHECTOMY, CHEMICAL; TREMOR;

EID: 0033900367     PISSN: 00913057     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0091-3057(00)00274-4     Document Type: Article

References (32)

1. Anderegg R.J., Betz R., Carr S.A., Crabb J.W., Duntze W. Structure of Saccharomyces cerevisiae mating hormone a-factor. J. Biol. Chem. 263:1988;18236-18240.
2. Cali J.J., Balcueva E.A., Rybalkin I., Robishaw J.D. Selective tissue distribution of G protein γ subunits, including a new form of the γ subunits identified by cDNA cloning. J. Biol. Chem. 267:1992;24023-24027.
3. Capdevila A., Decha-Umphai W., Song K.-H., Borchardt R.T., Wagner C. Pancreatic exocrine secretion is blocked by inhibitors of methylation. Arch. Biochem. Biophys. 345:1997;47-55.
4. Charlton C.G., Crowell B. Jr. Parkinson's Disease-like effects of S-adenosyl-L-methionine. Effects of L-dopa Pharmacol. Biochem. Behav. 43:1992;423-431.
5. Charlton C.G., Crowell B. Jr. Striatal dopamine depletion, tremors and hypokinesia following the intracranial injection of S-adenosylmethionine, a possible role of hypermethylation in Parkinsonism. Mol. Chem. Neuropathol. 26:1995;269-283.
6. Charlton C.G., Mack J. Substantia nigra degeneration and tyrosine hydroxylase depletion caused by excess S-adenosylmethionine in the rat brain. Mol. Neurobiol. 9:1994;149-161.
7. Clapham D.E., Neer E.J. G protein βγ subunits. Annu. Rev. Pharmacol. Toxicol. 37:1997;167-203.
8. Crowell B.G. Jr., Benson R., Schockley D., Charlton C.G. S-adenosyl-L-methionine decreases motor activity in the rat. Similarity to Parkinson's disease-like symptoms Behav. Neural. Biol. 59:1993;186-193.
9. De Waard M., Liu H., Walker D., Scott V.E.S., Gurnett C.A., Campbell K.P. Direct binding of G-protein βγ complex to voltage-dependent calcium channels. Nature. 385:1997;446-450.
10. Ding J., Lu D.J., Perez-Sala D., Ma Y.T., Maddox J.F., Gilbert B.A., Badwey J.A., Rando R.R. Farnesyl-L-cysteine analogs can inhibit or initiate superoxide release by human neutrophils. J. Biol. Chem. 269:1994;16837-16844.
11. Fukada Y., Matsuda T., Kokame K., Takao T., Shimonishi Y., Akino T., Yoshizawa T. Effects of carboxyl methylation of photoreceptor G protein γ-subunit in visual transduction. J. Biol. Chem. 269:1994;5163-5170.
12. Gudermann T., Kalkbrenner F., Schultz G. Diversity and selectivity of receptor-G protein interaction. Annu. Rev. Pharmacol. Toxicol. 36:1996;429-459.
13. Honykiewicz O. Dopamine (3-hydroxytyramine) and function. Pharmacol. Rev. 18:1966;925-964.
14. Hrycyna C.A., Clarke S. Maturation of isoprenylated proteins in Saccharomyces cerevisiae. J. Biol. Chem. 267:1992;10457-10464.
15. Imai Y., Davey J., Kawagishi-Kobayashi M., Yamamoto M. Genes encoding farnesyl cysteine carboxyl methyltransferase in Schizosaccharomyces pombe and Xenopus laevis. Mol. Cell. Biol. 17:1997;1543-1551.
16. Iniguez-Lluhi J.A., Simon M.I., Robishaw J.D., Gilman A.F. G protein βγ subunits synthesized in SF9 cells. Functional characterization and significance of prenylation of γ J. Biol. Chem. 267:1992;23409-23417.
17. Jones B.E., Boylan C.B., Fritsche M., Juhasz M., Jackson C., Wiegand S.J., Hyman C., Lindsay R.M., Altar C.A. A continuous striatal infusion of 6-hydroxydopamine produces a terminal axotomy and delayed behavioral effects. Brain Res. 709:1996;275-284.
18. Lamango, N. S.; Nesby, R. A.; Charlton, C. G.: Quantitative determination of S-adenosylmethionine-induced tremors: A possible tremor model for Parkinson's disease. Pharmacol. Biochem. Behav. (in press).
19. Metz S.A., Rabaglia M.E., Stock J.B., Kowluru A. Modulation of insulin secretion from normal rat islets by inhibitors of the post-translocational modifications of GTP-binding proteins. Biochem. J. 295:1993;31-40.
20. Parish C.A., Smrcka A.V., Rando R.R. Functional significance of βγ-subunit carboxymethylation for the activation of phospholipase C and phosphoinositide 3-kinase. Biochemistry. 34:1995;7722-7727.
21. Perez-Sala D., Gilbert B.A., Tan E.W., Rando R.R. Prenylated protein methyltransferases do not distinguish between farnesylated and geranylgeranylated substrates. Biochem. J. 284:1992;835-840.
22. Perez-Sala D., Tan E.W., Canada F.J., Rando R.R. Methylation and demethylation reactions of guanine nucleotide-binding proteins of retinal rod outer segments. Proc. Natl. Acad. Sci. USA. 88:1991;3043-3046.
23. Philips M.R., Pillinger M.H., Staud R., Volker C., Rosenfeld M.G., Weissmann G., Stock J.B. Carboxyl methylation of ras-related proteins during signal transduction in neutrophils. Science. 259:1993;977-980.
24. Pumiglia K.M., Levine H., Haske T., Habib T., Jove R., Decker S.J. A direct interaction between G-protein βγ subunits and the Raf-1 protein kinase. J. Biol. Chem. 270:1995;14251-14254.
25. Regazzi R., Sasaki T., Takahashi K., Jonas J.-C., Volker C., Stock J.B., Takai Y., Wollheim C.B. Prenylcysteine analogs mimicking the C-terminus of GTP-binding proteins stimulate exocytosis from permeabilized HIT-T15 cells. Comparison with the effect of Rab3AL peptide Biochim. Biophys. Acta. 1268:1995;269-278.
26. Scheer A., Gierschik P. Farnesylcysteine analogues inhibit chemotactic peptide receptor-mediated G-protein activation in human HL-60 granulocyte membranes. FEBS. 319:1993;110-114.
27. Scheer A., Gierschik P. S-prenylated cysteine analogues inhibit receptor-mediated G protein activation in native granulocyte and reconstituted bovine retinal rod outer segment membranes. Biochemistry. 34:1995;4952-4961.
28. Stock J.B., Clarke S., Koshland D.E. Jr. The protein carboxylmethyltransferase involved in Eschericia coli and Salmonella tymphimurium chemotaxis. Methods Enzymol. 106:1984;310-321.
29. Tan E.W., Perez-Sala D., Canada F.J., Rando R.R. Identifying the recognition unit for protein methylation. J. Biol. Chem. 266:1991;10719-10722.
30. Tisch D., Halpern M., Marciano D., Kloog Y., Aviram I. Activation of signaling pathways in HL60 cells and human neutrophils by farnesylthiosalicylate. Eur. J. Biochem. 242:1996;529-536.
31. Volker C., Lane P., Kwee C., Johnson M., Stock J. A single activity carboxyl methylates both farnesyl and geranylgeranyl cysteine residues. FEBS. 295:1991;189-194.
32. 2+ entry into calls by farnesylcyesteine analogs. Mol. Pharmacol. 50:1996;1495-1501.