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Volumn 164, Issue 3 I, 2000, Pages 716-721

p53 Accumulation associated with bcl-2, the proliferation marker MIB-1 and survival in patients with prostate cancer subjected to watchful waiting

Author keywords

Bcl 2; Biological; Genes; P53; Prostate; Prostatic neoplasms; Tumor markers

Indexed keywords

PROTEIN BCL 2; PROTEIN P53;

EID: 0033897377     PISSN: 00225347     EISSN: None     Source Type: Journal    
DOI: 10.1016/s0022-5347(05)67288-6     Document Type: Article
Times cited : (40)

References (49)
  • 1
    • 1842376981 scopus 로고
    • Bericht über die Zählung der am 1. April 1908 in Dänemark in ärztlicher Behandlung gewesenen Krebskranken
    • Fibiger, J. and Trier, S.: Bericht über die Zählung der am 1. April 1908 in Dänemark in ärztlicher Behandlung gewesenen Krebskranken. Z Krebsforschung, 9: 275, 1910
    • (1910) Z Krebsforschung , vol.9 , pp. 275
    • Fibiger, J.1    Trier, S.2
  • 2
    • 0031417094 scopus 로고    scopus 로고
    • The dilemma of prostate cancer. A growing human and economic burden irrespective of treatment strategies
    • Borre, M., Nerstrøm, B. and Overgaard, J.: The dilemma of prostate cancer. A growing human and economic burden irrespective of treatment strategies. Acta Oncol, 36: 681, 1997
    • (1997) Acta Oncol , vol.36 , pp. 681
    • Borre, M.1    Nerstrøm, B.2    Overgaard, J.3
  • 3
    • 0345367665 scopus 로고
    • Prediction of cancer incidence in the Nordic countries up to the years 2000 and 2010
    • Engeland, A., Haldorsen, T., Tretli, S. et al: Prediction of cancer incidence in the Nordic countries up to the years 2000 and 2010. APMIS, 38: 64, 1993
    • (1993) APMIS , vol.38 , pp. 64
    • Engeland, A.1    Haldorsen, T.2    Tretli, S.3
  • 4
    • 0028912191 scopus 로고
    • Prediction of cancer mortality in the Nordic countries up to the years 2000 and 2010, on the basis of relative survival analysis. A collaborative study of the five Nordic Cancer Registries
    • Engeland, A., Haldorsen, T., Tretli, S. et al: Prediction of cancer mortality in the Nordic countries up to the years 2000 and 2010, on the basis of relative survival analysis. A collaborative study of the five Nordic Cancer Registries. APMIS, suppl., 49: 1, 1995
    • (1995) APMIS, Suppl. , vol.49 , pp. 1
    • Engeland, A.1    Haldorsen, T.2    Tretli, S.3
  • 5
    • 0030803987 scopus 로고    scopus 로고
    • The natural history of prostate carcinoma based on a Danish population treated with no intent to cure
    • Borre, M., Nerstrøm, B. and Overgaard, J.: The natural history of prostate carcinoma based on a Danish population treated with no intent to cure. Cancer, 80: 917, 1997
    • (1997) Cancer , vol.80 , pp. 917
    • Borre, M.1    Nerstrøm, B.2    Overgaard, J.3
  • 6
    • 0027531915 scopus 로고
    • Trends in prostate cancer care in the United States, 1974-1990: Observations from the patient care evaluation studies of the American College of Surgeons Commission on Cancer
    • Mettlin, C., Jones, G. W. and Murphy, G. P.: Trends in prostate cancer care in the United States, 1974-1990: observations from the patient care evaluation studies of the American College of Surgeons Commission on Cancer. CA Cancer J Clin, 43:83, 1993
    • (1993) CA Cancer J Clin , vol.43 , pp. 83
    • Mettlin, C.1    Jones, G.W.2    Murphy, G.P.3
  • 7
    • 0025006348 scopus 로고
    • Mutant p53: The commonest genetic abnormality in human cancer?
    • Harris, A. L.: Mutant p53: the commonest genetic abnormality in human cancer? J Pathol, 162: 5, 1990
    • (1990) J Pathol , vol.162 , pp. 5
    • Harris, A.L.1
  • 8
    • 0025879530 scopus 로고
    • Abberant expression of the p53 oncoprotein is a common feature of a wide spectrum of human malignancies
    • Bartek, J., Bartkova, J., Vojtesek, B. et al: Abberant expression of the p53 oncoprotein is a common feature of a wide spectrum of human malignancies. Oncogene, 6: 1699, 1991
    • (1991) Oncogene , vol.6 , pp. 1699
    • Bartek, J.1    Bartkova, J.2    Vojtesek, B.3
  • 9
    • 0025975701 scopus 로고
    • Protein synthesis required to anchor a mutant p53 protein which is temperature-sensitive for nuclear transport
    • Gannon, J. V. and Lane, D. P.: Protein synthesis required to anchor a mutant p53 protein which is temperature-sensitive for nuclear transport. Nature, 349: 802, 1991
    • (1991) Nature , vol.349 , pp. 802
    • Gannon, J.V.1    Lane, D.P.2
  • 10
    • 0022646788 scopus 로고
    • Localization of the gene for human p53 tumour antigen to band 17p13
    • Isobe, M., Emanuel, B. S., Givol, D. et al: Localization of the gene for human p53 tumour antigen to band 17p13. Nature, 320: 84, 1986
    • (1986) Nature , vol.320 , pp. 84
    • Isobe, M.1    Emanuel, B.S.2    Givol, D.3
  • 11
    • 0025876591 scopus 로고
    • The p53 tumour suppressor gene
    • Levine, A. J., Momand, J. and Finlay, C. A.: The p53 tumour suppressor gene. Nature, 351: 453, 1991
    • (1991) Nature , vol.351 , pp. 453
    • Levine, A.J.1    Momand, J.2    Finlay, C.A.3
  • 12
    • 0026669469 scopus 로고
    • p53 function and dysfunction
    • Vogelstein, B. and Kinzler, K. W.: p53 function and dysfunction. Cell, 70: 523, 1992
    • (1992) Cell , vol.70 , pp. 523
    • Vogelstein, B.1    Kinzler, K.W.2
  • 13
    • 0027109075 scopus 로고
    • p53, guardian of the genome
    • Lane, D. P.: p53, guardian of the genome. Nature, 358:15, 1992
    • (1992) Nature , vol.358 , pp. 15
    • Lane, D.P.1
  • 14
    • 0027536951 scopus 로고
    • p53-mediated cell death: Relationship to cell cycle control
    • Yonish-Rouach, E., Grunwald, D., Wilder, S. et al: p53-mediated cell death: relationship to cell cycle control. Mol Cell Biol, 13: 1415, 1993
    • (1993) Mol Cell Biol , vol.13 , pp. 1415
    • Yonish-Rouach, E.1    Grunwald, D.2    Wilder, S.3
  • 15
    • 0026769713 scopus 로고
    • An immunochemical analysis of the human nuclear phosphoprotein p53. New monoclonal antibodies and epitope mapping using recombinant p53
    • Vojtesek, B., Bartek, J., Midgley, C. A. et al: An immunochemical analysis of the human nuclear phosphoprotein p53. New monoclonal antibodies and epitope mapping using recombinant p53. J Immunol Methods, 151: 237, 1992
    • (1992) J Immunol Methods , vol.151 , pp. 237
    • Vojtesek, B.1    Bartek, J.2    Midgley, C.A.3
  • 16
    • 0027331484 scopus 로고
    • p53 protein accumulation and gene mutation in the progression of human prostate carcinoma
    • Navone, N. M., Troncoso, P., Pisters, L. L. et al: p53 protein accumulation and gene mutation in the progression of human prostate carcinoma. J Natl Cancer Inst, 85: 1657, 1993
    • (1993) J Natl Cancer Inst , vol.85 , pp. 1657
    • Navone, N.M.1    Troncoso, P.2    Pisters, L.L.3
  • 17
    • 0028817084 scopus 로고
    • Immunohistochemical detection of p53 protein as a prognostic indicator in prostate cancer
    • Shurbaji, M. S., Kalbfleisch, J. H. and Thurmond, T. S.: Immunohistochemical detection of p53 protein as a prognostic indicator in prostate cancer. Hum Pathol, 26: 106, 1995
    • (1995) Hum Pathol , vol.26 , pp. 106
    • Shurbaji, M.S.1    Kalbfleisch, J.H.2    Thurmond, T.S.3
  • 18
    • 0029851180 scopus 로고    scopus 로고
    • bcl-2 overexpression combined with p53 protein accumulation correlates with hormone-refractory prostate cancer
    • Apakama, I., Robinson, M. C., Walter, N. M. et al: bcl-2 overexpression combined with p53 protein accumulation correlates with hormone-refractory prostate cancer. Br J Cancer, 74:1258, 1996
    • (1996) Br J Cancer , vol.74 , pp. 1258
    • Apakama, I.1    Robinson, M.C.2    Walter, N.M.3
  • 19
    • 0028837632 scopus 로고
    • p53 nuclear protein expression is an independent prognostic marker in clinically localized prostate cancer patients undergoing radical prostatectomy
    • Bauer, J. J., Sesterhenn, I. A., Mostofi, F. K et al: p53 nuclear protein expression is an independent prognostic marker in clinically localized prostate cancer patients undergoing radical prostatectomy. Clin Cancer Res, 1: 1295, 1995
    • (1995) Clin Cancer Res , vol.1 , pp. 1295
    • Bauer, J.J.1    Sesterhenn, I.A.2    Mostofi, F.K.3
  • 20
    • 0029795396 scopus 로고    scopus 로고
    • Elevated levels of apoptosis regulator proteins p53 and bcl-2 are independent prognostic biomarkers in surgically treated localized prostate cancer
    • Bauer, J. J., Sesterhenn, I. A., Mostofi, F. K et al: Elevated levels of apoptosis regulator proteins p53 and bcl-2 are independent prognostic biomarkers in surgically treated localized prostate cancer. J Urol, 156: 1511, 1996
    • (1996) J Urol , vol.156 , pp. 1511
    • Bauer, J.J.1    Sesterhenn, I.A.2    Mostofi, F.K.3
  • 21
    • 0029922216 scopus 로고    scopus 로고
    • Determining prognosis of clinically localized prostate cancer by immunohistochemical detection of mutant p53
    • Stricker, H. J., Jay, J. K., Linden, M. D. et al: Determining prognosis of clinically localized prostate cancer by immunohistochemical detection of mutant p53. Urology, 47: 366, 1996
    • (1996) Urology , vol.47 , pp. 366
    • Stricker, H.J.1    Jay, J.K.2    Linden, M.D.3
  • 22
    • 0030008078 scopus 로고    scopus 로고
    • Prognostic significance of bcl-2 in clinically localized prostate cancer
    • Bubendorf, L., Sauter, G., Moch, H. et al: Prognostic significance of bcl-2 in clinically localized prostate cancer. Am J Pathol, 148: 1557, 1996
    • (1996) Am J Pathol , vol.148 , pp. 1557
    • Bubendorf, L.1    Sauter, G.2    Moch, H.3
  • 23
    • 0029966627 scopus 로고    scopus 로고
    • Clustered p53 immunostaining: A novel pattern associated with prostate cancer progression
    • Yang, G., Stapleton, A. M., Wheeler, T. M. et al: Clustered p53 immunostaining: a novel pattern associated with prostate cancer progression. Clin Cancer Res, 2: 399, 1996
    • (1996) Clin Cancer Res , vol.2 , pp. 399
    • Yang, G.1    Stapleton, A.M.2    Wheeler, T.M.3
  • 24
    • 0031397368 scopus 로고    scopus 로고
    • The expression of waf-1, p53 and bcl-2 in prostatic adenocarcinoma
    • Byrne, R. L., Home, C. H., Robinson, M. C. et al: The expression of waf-1, p53 and bcl-2 in prostatic adenocarcinoma. Br J Urol, 79: 190, 1997
    • (1997) Br J Urol , vol.79 , pp. 190
    • Byrne, R.L.1    Home, C.H.2    Robinson, M.C.3
  • 25
    • 0030829938 scopus 로고    scopus 로고
    • Combined analysis with bcl-2 and p53 immunostaining predicts poorer prognosis in prostatic carcinoma
    • Matsushima, H., Kitamura, T., Goto, T. et al: Combined analysis with bcl-2 and p53 immunostaining predicts poorer prognosis in prostatic carcinoma. J Urol, 158: 2278, 1997
    • (1997) J Urol , vol.158 , pp. 2278
    • Matsushima, H.1    Kitamura, T.2    Goto, T.3
  • 26
    • 0030967596 scopus 로고    scopus 로고
    • p53, bcl2 and retinoblastoma proteins as long-term prognostic markers in localized carcinoma of the prostate
    • Theodorescu, D., Broder, S. R., Boyd, J. C. et al: p53, bcl2 and retinoblastoma proteins as long-term prognostic markers in localized carcinoma of the prostate. J Urol, 158: 131, 1997
    • (1997) J Urol , vol.158 , pp. 131
    • Theodorescu, D.1    Broder, S.R.2    Boyd, J.C.3
  • 27
    • 0031942254 scopus 로고    scopus 로고
    • Assessment of the biologic markers p53, Ki-67, and apoptotic index as predictive indicators of prostate carcinoma recurrence after surgery
    • Stapleton, A. M., Zbell, P., Kattan, M. W. et al: Assessment of the biologic markers p53, Ki-67, and apoptotic index as predictive indicators of prostate carcinoma recurrence after surgery, Cancer, 82: 168, 1998
    • (1998) Cancer , vol.82 , pp. 168
    • Stapleton, A.M.1    Zbell, P.2    Kattan, M.W.3
  • 28
    • 0032853502 scopus 로고    scopus 로고
    • Preoperative p53, bcl-2, CD44 and E-cadherin immunohistochemistry as predic-tors of biochemical relapse after radical prostatectomy
    • Brewster, S. F., Oxley, J. D., Trivella, M. et al: Preoperative p53, bcl-2, CD44 and E-cadherin immunohistochemistry as predic-tors of biochemical relapse after radical prostatectomy. J Urol, 161:1238, 1999
    • (1999) J Urol , vol.161 , pp. 1238
    • Brewster, S.F.1    Oxley, J.D.2    Trivella, M.3
  • 29
    • 0032828118 scopus 로고    scopus 로고
    • BCL-2 and p53 expression in clinically localized prostate cancer predicts response to external beam radiotherapy
    • Scherr, D. S., Vaughan, E. D., Jr., Wei, J. et al: BCL-2 and p53 expression in clinically localized prostate cancer predicts response to external beam radiotherapy. J Urol, 162:12, 1999
    • (1999) J Urol , vol.162 , pp. 12
    • Scherr, D.S.1    Vaughan Jr., E.D.2    Wei, J.3
  • 30
    • 0033559960 scopus 로고    scopus 로고
    • p53 protein overexpression is associated with increased cell proliferation in patients with locally recurrent prostate carcinoma after radiation therapy
    • Cheng, L., Sebo, T. J., Cheville, J. C. et al: p53 protein overexpression is associated with increased cell proliferation in patients with locally recurrent prostate carcinoma after radiation therapy. Cancer, 85: 1293, 1999
    • (1999) Cancer , vol.85 , pp. 1293
    • Cheng, L.1    Sebo, T.J.2    Cheville, J.C.3
  • 31
    • 0032699925 scopus 로고    scopus 로고
    • p53 and bcl-2 immunohistochemistry in pretreatment prostate needle biopsies to predict recurrence of prostate cancer after radical prostatectomy
    • Stackhouse, G. B., Sesterhenn, I. A., Bauer, J. J. et al: p53 and bcl-2 immunohistochemistry in pretreatment prostate needle biopsies to predict recurrence of prostate cancer after radical prostatectomy. J Urol, 162: 2040, 1999
    • (1999) J Urol , vol.162 , pp. 2040
    • Stackhouse, G.B.1    Sesterhenn, I.A.2    Bauer, J.J.3
  • 32
    • 0028202172 scopus 로고
    • Prostatic carcinoma: A multivariate analysis of prognostic factors
    • Berner, A., Harvei, S., Tretli, S. et al: Prostatic carcinoma: a multivariate analysis of prognostic factors. Br J Cancer, 69: 924, 1994
    • (1994) Br J Cancer , vol.69 , pp. 924
    • Berner, A.1    Harvei, S.2    Tretli, S.3
  • 33
    • 0030035620 scopus 로고    scopus 로고
    • p53 immunoreactivity as prognostic marker for cancer-specific survival in prostate cancer
    • Stattin, P., Bergh, A., Karlberg, L. et al: p53 immunoreactivity as prognostic marker for cancer-specific survival in prostate cancer. Eur Urol, 30: 65, 1996
    • (1996) Eur Urol , vol.30 , pp. 65
    • Stattin, P.1    Bergh, A.2    Karlberg, L.3
  • 34
    • 0029783149 scopus 로고    scopus 로고
    • An uncertain role for p53 gene alterations in human prostate cancers
    • Brooks, J. D., Bova, G. S., Ewing, C. M. et al: An uncertain role for p53 gene alterations in human prostate cancers. Cancer Res, 56: 3814, 1996
    • (1996) Cancer Res , vol.56 , pp. 3814
    • Brooks, J.D.1    Bova, G.S.2    Ewing, C.M.3
  • 35
    • 0015383455 scopus 로고
    • Apoptosis: A basic biological phenomenon with wide-ranging implications in tissue kinetics
    • Kerr, J. F., Wyllie, A. H. and Currie, A. R.: Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics. Br J Cancer, 26: 239, 1972
    • (1972) Br J Cancer , vol.26 , pp. 239
    • Kerr, J.F.1    Wyllie, A.H.2    Currie, A.R.3
  • 36
    • 3142639477 scopus 로고    scopus 로고
    • Immunohistochemical BCL-2 and Ki-67 expression predict survival in prostate cancer patients followed expectantly
    • Borre, M., Stausbøl-Grøn, B., Nerstrøm, B. et al: Immunohistochemical BCL-2 and Ki-67 expression predict survival in prostate cancer patients followed expectantly. Prostate Cancer Prostatic Dis, 5: 268, 1998
    • (1998) Prostate Cancer Prostatic Dis , vol.5 , pp. 268
    • Borre, M.1    Stausbøl-Grøn, B.2    Nerstrøm, B.3
  • 37
    • 0032460557 scopus 로고    scopus 로고
    • Tumor cell proliferation and survival in patients with prostate cancer followed expectantly
    • Borre, M., Bentzen, S. M. Nerstrøm, B. et al: Tumor cell proliferation and survival in patients with prostate cancer followed expectantly. J Urol, 159: 1609, 1998
    • (1998) J Urol , vol.159 , pp. 1609
    • Borre, M.1    Bentzen, S.M.2    Nerstrøm, B.3
  • 38
    • 0027057589 scopus 로고
    • Monoclonal antibodies against recombinant parts of the Ki-67 antigen (MIB-1 and MIB-3) detect proliferating cells in microwave-processed formalin-fixed paraffin sections
    • Cattoretti, G., Becker, M. H., Key, G. et al: Monoclonal antibodies against recombinant parts of the Ki-67 antigen (MIB-1 and MIB-3) detect proliferating cells in microwave-processed formalin-fixed paraffin sections. J Pathol, 168: 357, 1992
    • (1992) J Pathol , vol.168 , pp. 357
    • Cattoretti, G.1    Becker, M.H.2    Key, G.3
  • 39
    • 0025204548 scopus 로고
    • Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death
    • Hockenbury, D., Nunøez, G., Millimam, C. et al: Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death. Nature, 348: 334, 1990
    • (1990) Nature , vol.348 , pp. 334
    • Hockenbury, D.1    Nunøez, G.2    Millimam, C.3
  • 40
    • 0029742823 scopus 로고    scopus 로고
    • Loss of tumor marker-immunostaining intensity on stored paraffin slides of breast cancer
    • Jacobs, T. W., Prioleau, J. E., Stillman, I. E. et al: Loss of tumor marker-immunostaining intensity on stored paraffin slides of breast cancer. J Natl Cancer Inst, 88:1054, 1996
    • (1996) J Natl Cancer Inst , vol.88 , pp. 1054
    • Jacobs, T.W.1    Prioleau, J.E.2    Stillman, I.E.3
  • 41
    • 0015375422 scopus 로고
    • Carcinoma of the prostate: Prognostic evaluation of certain pathologic features in 208 radical prostatectomies. Examined by the step-section technique
    • Byar, D. P. and Mostofi, F. K.: Carcinoma of the prostate: prognostic evaluation of certain pathologic features in 208 radical prostatectomies. Examined by the step-section technique. Cancer, 30: 5, 1972
    • (1972) Cancer , vol.30 , pp. 5
    • Byar, D.P.1    Mostofi, F.K.2
  • 42
    • 0031710964 scopus 로고    scopus 로고
    • Microvessel density predicts survival in prostate cancer patients subjected to watchful waiting
    • Borre, M., Offersen, B. V., Nerstrøm, B. et al: Microvessel density predicts survival in prostate cancer patients subjected to watchful waiting. Br J Cancer, 78: 940, 1998
    • (1998) Br J Cancer , vol.78 , pp. 940
    • Borre, M.1    Offersen, B.V.2    Nerstrøm, B.3
  • 43
    • 0031757941 scopus 로고    scopus 로고
    • Expression of Bcl-2, Bax, and p53 in high-grade prostatic intraepithelial neoplasia and localized prostate cancer: Relationship with apoptosis and proliferation
    • Johnson, M. I., Robinson, M. C., Marsh, C. et al: Expression of Bcl-2, Bax, and p53 in high-grade prostatic intraepithelial neoplasia and localized prostate cancer: relationship with apoptosis and proliferation. Prostate, 37: 223, 1998
    • (1998) Prostate , vol.37 , pp. 223
    • Johnson, M.I.1    Robinson, M.C.2    Marsh, C.3
  • 44
    • 0030481099 scopus 로고    scopus 로고
    • The role of the p53 tumor suppressor gene in prostate cancer: A possible biomarker?
    • Heidenberg, H. B., Bauer, J. J., McLeod, D. G. et al: The role of the p53 tumor suppressor gene in prostate cancer: a possible biomarker? Urology, 48: 971, 1996
    • (1996) Urology , vol.48 , pp. 971
    • Heidenberg, H.B.1    Bauer, J.J.2    McLeod, D.G.3
  • 45
    • 0028142049 scopus 로고
    • p53 protein accumulation detected by five different antibodies: Relationship to prognosis and heat shock protein 70 in breast cancer
    • Elledge, R. M., Clark, G. M., Fuqua, S. A. et al: p53 protein accumulation detected by five different antibodies: relationship to prognosis and heat shock protein 70 in breast cancer. Cancer Res, 54: 3752, 1994
    • (1994) Cancer Res , vol.54 , pp. 3752
    • Elledge, R.M.1    Clark, G.M.2    Fuqua, S.A.3
  • 46
    • 0028084531 scopus 로고
    • Problems with p53 immunohistochemical staining: The effect of fixation and variation in the methods of evaluation
    • Fisher, C. J., Gillett, C. E., Vojtesek, B. et al: Problems with p53 immunohistochemical staining: the effect of fixation and variation in the methods of evaluation. Br J Cancer, 69: 26, 1994
    • (1994) Br J Cancer , vol.69 , pp. 26
    • Fisher, C.J.1    Gillett, C.E.2    Vojtesek, B.3
  • 47
    • 0030596311 scopus 로고    scopus 로고
    • Assessing p53 status in breast cancer prognosis: Where should you put the thermometer if you think your p53 is sick?
    • Elledge, R. M.: Assessing p53 status in breast cancer prognosis: where should you put the thermometer if you think your p53 is sick? J Natl Cancer Inst, 88: 141, 1996
    • (1996) J Natl Cancer Inst , vol.88 , pp. 141
    • Elledge, R.M.1
  • 48
    • 0030218872 scopus 로고    scopus 로고
    • p53 expression, proliferation marker Ki-S5, DNA content and serum PSA: Possible biopotential markers in human prostatic cancer
    • Papadopoulos, I., Rudolph, P., Wirth, B. et al: p53 expression, proliferation marker Ki-S5, DNA content and serum PSA: possible biopotential markers in human prostatic cancer. Urology, 48: 261, 1996
    • (1996) Urology , vol.48 , pp. 261
    • Papadopoulos, I.1    Rudolph, P.2    Wirth, B.3
  • 49
    • 0029819406 scopus 로고    scopus 로고
    • Protein expression of p53, bcl-2, and Ki-67 (MIB-1) as prognostic biomarkers in patients with surgically treated, clinically localized prostate cancer
    • Moul, J. W., Bettencourt, M-C., Sesterhenn, I. A. et al: Protein expression of p53, bcl-2, and Ki-67 (MIB-1) as prognostic biomarkers in patients with surgically treated, clinically localized prostate cancer. Surgery, 120:159, 1996
    • (1996) Surgery , vol.120 , pp. 159
    • Moul, J.W.1    Bettencourt, M.-C.2    Sesterhenn, I.A.3


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