Endogenous IGFBP-3 is protected from inducible IGFBP-3 protease activity in normal adult serum

Growth Hormone and IGF Research

Volumn 10, Issue 2, 2000, Pages 71-77

  Maile, L A ^a   Whellams, E J ^a   Holly, J M P ^a  

^a UNIVERSITY OF BRISTOL   (United Kingdom)

Author keywords

Heparin; IGFBP 3; Proteolysis

Indexed keywords

HEPARIN; PROTEINASE; SOMATOMEDIN BINDING PROTEIN 3; ZINC;

ARTICLE; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME BLOOD LEVEL; ENZYME INDUCTION; FEMALE; HUMAN; HUMAN EXPERIMENT; NORMAL HUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION;

EID: 0033888333     PISSN: 10966374     EISSN: None     Source Type: Journal    
DOI: 10.1054/ghir.2000.0142     Document Type: Article

References (25)

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5. Fasting affects serum insulin-like growth factors (IGFs) and IGF binding proteins differently in patients with non-insulin dependent diabetes versus non-obese and obese weight matched subjects
6. Increased proteolysis of insulin-like growth factor binding protein-3 (IGFBP-3) in non-insulin dependent diabetes serum, with elevation of a 29 kDa glycosylated IGFBP-3 fragment contained in the approximately 130-150 kDa ternary complex
7. Insulin-like growth factor binding protein-3 (IGFBP-3) proteolysis in children with insulin-dependent diabetes mellitus: Possible role for insulin in the regulation of IGFBP-3 protease activity
8. Insulin-like growth factor binding protein (IGFBP) proteolysis: Occurrence, identification, role and regulation
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10. Local disruption of the insulin-like growth factor system in the arthritic joint
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13. Liberation of immunoreactive somatomedin-C from its binding proteins by proteolytic enzymes and heparin
14. A simple assay for the proteolysis of insulin-like growth factor binding protein-3 (IGFBP-3)
15. Heparin, heparan sulfate and dermatan sulfate regulate formation of the insulin-like growth factor-I and insulin-like growth factor-binding protein complexes
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21. The heparin binding domain of insulin-like growth factor binding protein (IGFBP)-3 increases susceptibility of IGFBP-3 to proteolysis
22. Sulfated glycosaminoglycans enhance tumor cell invasion in vitro by stimulating plasminogen activation
23. Mutlivalent cations depress ligand affinity of insulin-like growth factor binding proteins-3 and -5 on human GM-10 fibroblast cell surface
24. Identification of the major sites of phosphorylation in IGFBP-3
25. Identification and mutagenesis of putative phosphorylation sites on IGFBP-3