The current status of gene therapy

Seminars in Oncology

Volumn 27, Issue 4, 2000, Pages 39-43

  Clayman, G L ^a  

^a UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN P53; VIRUS VECTOR;

ADENOVIRUS; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; CANCER ADJUVANT THERAPY; CELL CYCLE; CLINICAL TRIAL; DNA DAMAGE; GENE FUNCTION; GENE THERAPY; GENETIC TRANSDUCTION; HEAD CANCER; HUMAN; NECK CANCER; NONHUMAN; PRIORITY JOURNAL; REVIEW; SQUAMOUS CELL CARCINOMA;

CARCINOMA, SQUAMOUS CELL; CLINICAL TRIALS; GENE THERAPY; GENES, P53; HEAD AND NECK NEOPLASMS; HUMANS;

EID: 0033887419     PISSN: 00937754     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (19)

1. Wild-type but not mutant p53 suppresses the growth of human lung cancer cells bearing multiple genetic lesions
2. Suppression of tumorigenicity of human prostate carcinoma cells by replacing a mutated Rb gene
3. Growth inhibitory effect of anti-K-ras adenovirus on lung cancer cells
4. Stable expression of the wild-type p53 gene in human lung cancer cells after retrovirus-mediated gene transfer
5. High-efficiency gene transfer and high-level expression of wild-type p53 in human lung cancer cells mediated by recombinant adenovirus
6. Growth suppression of human head and neck cancer cells by the induction of a wild-type p53 gene via a recombinant adenovirus
7. Apoptosis induction mediated by wild-type p53 adenoviral gene transfer in squamous cell carcinoma of the head and neck
8. In vivo molecular therapy with p53 adenovirus for microscopic residual head and neck squamous carcinoma
9. A retroviral wild-type p53 expression vector penetrates human lung cancer spheroids and inhibits growth by inducing apoptosis
10. Efficacy of multiple administrations of a recombinant adenovirus expressing wild-type p53 in an immune-competent mouse tumor model
11. Adenovirus-mediated wild-type p53 gene transfer down-regulates vascular endothelial growth factor expression and inhibits angiogenesis in human colon cancer
12. Bystander effect in the adenovirus-mediated wild-type p53 gene therapy model of human squamous cell carcinoma of the head and neck
13. Expression of apoptosis-related genes in human head and neck squamous cell carcinomas undergoing p53-mediated programmed cell death
14. In vitro growth suppression by adenoviral transduction of p21 and p16 in squamous cell carcinoma of the head and neck: A research model for combination gene therapy
15. Adenovirus-mediated p53 gene transfer in patients with advanced recurrent head and neck squamous cell carcinoma
16. Adenovirus-mediated wild-type p53 gene transfer as a surgical adjuvant in advanced head and neck cancers
17. Gene therapy for cancer: What have we done and where are we going?
18. A phase I study of gene therapy with recombinant intraperitoneal p53 in recurrent ovarian cancer