Elevated protein content and prolyl 4-hydroxylase activity in severely degenerated human annulus fibrosus

Connective Tissue Research

Volumn 41, Issue 2, 2000, Pages 93-99

  Kaapa, E ^a   Wang, W ^a   Takala, T E S ^a   Poussa, M ^a   Konttinen, Y T ^a   Lammi, M J ^a   Vanharanta, H ^a  

^a UNIVERSITY OF EASTERN FINLAND   (Finland)

Author keywords

Collagen biosynthesis; Collagen crosslinks; Disc degeneration; Prolyl 4 hydroxylase

Indexed keywords

DEOXYPYRIDINOLINE; PROCOLLAGEN GLUCOSYLTRANSFERASE; PROCOLLAGEN PROLINE 2 OXOGLUTARATE 4 DIOXYGENASE; PYRIDINOLINE;

ARTICLE; COLLAGEN METABOLISM; COLLAGEN SYNTHESIS; CONTROLLED STUDY; CROSS LINKING; DISEASE ASSOCIATION; HUMAN; HUMAN TISSUE; INTERVERTEBRAL DISK DEGENERATION; PROTEIN LOCALIZATION; TISSUE DISTRIBUTION;

EID: 0033886348     PISSN: 03008207     EISSN: None     Source Type: Journal    
DOI: 10.3109/03008200009067661     Document Type: Article

References (46)

1. Quantitative changes with age of proteoglycans of human lumbar discs
2. Biochemical changes in intervertebral disc degeneration
3. Degeneration and the chemical composition of the human lumbar intervertebral disc
4. Three-dimensional observation of collagen framework of lumbar intervertebral discs
5. Tissue mechanics
6. Properties of spinal materials
7. The distribution and arrangement of elastic fibers in the intervertebral disc of the adult human
8. Annular tears and disc degeneration in the lumbar spine. A post-mortem study of 135 discs
9. Degenerative changes in the intervertebral discs of the lumbar spine and their sequelae
10. Anulus tears and intervertebral disc degeneration. An experimental study using an animal model
11. Platelet-derived growth factor and vascular endothelial growth factor expression in disc herniation tissue. An immunohistochemical study
12. Mechanosensitive afferent units in the lumbar intervertebral disc and adjacent muscle
13. Mechanoreceptors in intervertebral disc. Morphology, distribution, and neuropeptides
14. The stages of disc degeneration as revealed by discograms
15. Preliminary evaluation of a scheme for grading the gross morphology of the human intervertebral disc
16. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
17. Modification of a specific assay for hydroxyproline in urine
18. Posttranslational enzymes in the biosynthesis of collagen: Intracellular enzymes
19. Assay of collagen galactosyltransferase and collagen glucosyltransferase activities and preliminary characterization of enzyme reactions with transferase from chick embryo cartilage
20. Quantitative analysis of the pyridinium crosslinks of collagen in urine using ion-paired reversed-phase high-performance liquid chromatography
21. Cross-linking in collagen and elastin
22. The noncollagenous proteins of the intervertebral disc
23. Biochemistry of the intervertebral disc
24. Protocollagen prolylhydroxylase activity in work-induced hypertrophy of rat muscle
25. Effects of long-term verapamil treatment on blood pressure, cardiac hypertrophy and collagen metabolism in spontaneously hypertensive rats
26. Effects of denervation and immobilization on collagen synthesis in rat skeletal muscle and tendon
27. Effects of joint loading on articular cartilage collagen metabolism: Assay of procollagen prolyl 4-hydroxylase and galactosylhydroxylysyl glucosyltransferase
28. Age- and training-related changes in the collagen metabolism of rat skeletal muscle
29. Collagens in the injured porcine intervertebral disc
30. Enhanced prolylhydroxylase activity in the posterior annulus fibrosus of canine intervertebral discs following long-term running exercise
31. The human lumbar intervertebral disc. Evidence for changes in the biosynthesis and denaturation of the extracellular matrix with growth, maturation, ageing, and degeneration
32. Collagenolytic enzyme systems in human intervertebral disc. Their control, mechanism, and their possible role in the initiation of biomechanical failure
33. Abnormal connective tissue degrading enzyme patterns in prolapsed intervertebral discs
34. Enhanced denaturation of the alpha (II) chains of type-II collagen in normal adult human intervertebral discs compared with femoral articular cartilage
35. Basic science perspectives
36. Quantitation of hydroxypyridinium crosslinks in collagen by high-performance liquid chromatography
37. Collagen cross-links in human lumbar intervertebral disc aging
38. Ageing and zonal variation in post-translational modification of collagen in normal human articular cartilage
39. Immunofluorescent staining for collagen and proteoglycan in normal and scoliotic intervertebral discs
40. Collagens of the disc
41. Collagen types around the cells of the intervertebral disc and cartilage end plate: An immunolocalization study
42. Immunolocalization of type X collagen in human lumbar intervertebral discs during ageing and degeneration
43. Collagen: Structure, function, and metabolism in normal and fibrotic tissues
44. Expression of type I, III, and VI collagen mRNAs in experimentally injured porcine intervertebral disc
45. Degenerated annulus fibrosus of the intervertebral disc contains collagen type III
46. Structural specialization in tendons under compression