Expression of a complete and functional complement system by human neuronal cells in vitro

International Immunology

Volumn 12, Issue 7, 2000, Pages 1015-1023

  Thomas, Anne ^a   Gasque, Philippe ^a,c   Vaudry, David ^b   Gonzalez, Bruno ^a,c   Fontaine, Marc ^a  

^a INSERM   (France)

^b UNIVERSITÉ DE ROUEN   (France)

^c CARDIFF UNIVERSITY   (United Kingdom)

Author keywords

Brain; Complement; Differentiation; Expression; Inflammation; Neuroimmunology; Neuron

Indexed keywords

COMPLEMENT; COMPLEMENT COMPONENT C1Q; COMPLEMENT COMPONENT C1S INHIBITOR; COMPLEMENT COMPONENT C3; COMPLEMENT COMPONENT C4; COMPLEMENT COMPONENT C5; COMPLEMENT COMPONENT C6; COMPLEMENT COMPONENT C7; COMPLEMENT COMPONENT C9; COMPLEMENT FACTOR H; MESSENGER RNA; POLYPEPTIDE;

AMINO TERMINAL SEQUENCE; ARTICLE; ASTROCYTE; BIOSYNTHESIS; BRAIN; CEREBELLUM; CONTROLLED STUDY; GENE EXPRESSION; GRANULE CELL; HUMAN; HUMAN CELL; IMMUNOREACTIVITY; IN VITRO STUDY; MICROGLIA; NERVE CELL; NERVE CELL DIFFERENTIATION; NEUROBLASTOMA CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SECRETION; PROTEIN SYNTHESIS; REGULATORY MECHANISM; TUMOR CELL LINE; WESTERN BLOTTING;

EID: 0033880688     PISSN: 09538178     EISSN: None     Source Type: Journal    
DOI: 10.1093/intimm/12.7.1015     Document Type: Article

References (47)

1. The role of complement in inflammation and phagocytosis
2. Biosynthesis of the complement components and the regulatory proteins of the alternative complement pathway of human peripheral blood monocytes
3. Biosynthesis of complement by human monocytes
4. Synovial fibroblast-like cells synthesize seven proteins of the complement system
5. Synthesis of C3, C5, C6, C7, C8 and C9 by human fibroblasts
6. Pulmonary alveolar type II epithelial cells synthesize and secrete proteins of the classical and alternative complement pathways
7. Biosynthesis of complement factor H by human umbilical vein endothelial cells: Regulation by T cell growth factor and IFN-γ
8. Estrogen regulation of tissue-specific expression of complement C3
9. A-431 cells and human keratinocytes synthesize and secrete the third component of complement
10. Expression and localization of proteins of the complement system in human skin
11. Interferon-γ induces synthesis of complement alternative pathway proteins by human endothelial cells in culture
12. Expression of complement alternative pathway proteins by endothelial cells. Differential regulation by interleukin-1 and glucocorticoids
13. Interleukin-2 mediates stimulation of complement C3 biosynthesis in human proximal tubular epithelial cells
14. In vitro biosynthesis of complement factor I by human endothelial cells
15. Adipsin and an endogenous pathway of complement from adipose cells
16. Human adipsin is identical to complement factor D and is expressed at high levels in adipose tissue
17. Transcriptional regulation of the production of the third component of complement (C3) by 1α,25-dihydroxyvitamin D3 in mouse marrow-derived stromal cells (ST2) and primary osteoblastic cells
18. The specific production of the third component of complement by osteoblastic cells treated with 1α,25-dihydroxyvitamin D3
19. Expression of the complement alternative pathway by human myoblasts in vitro. Biosynthesis of C3, factor B, factor H and factor I
20. Human skeletal myoblasts spontaneously activate allogenic complement but are resistant to killing
21. Complement classical pathway expression by human skeletal myoblasts in vitro
22. Nouvelles fonctions pour le systeme du complement. Apport de l'etude des syntheses locales
23. Expression of complement in the brain: Role in health and disease
24. Complement mRNA in the mammalian brain: Responses to Alzheimer's disease and experimental brain lesioning
25. Complement C1qB and C4 mRNAs responses to lesioning in rat brain
26. Synthetic Alzheimer amyloid β/A4 peptides enhance production of complement C3 component by cultured microglial cells
27. Primary cultures of murine astrocytes produce C3 and factor B, two components of the alternative pathway of complement activation
28. Detection of complement protein mRNA in human astrocytes by the polymerase chain reaction
29. Induction of C3 expression in astrocytes is regulated by cytokines and Newcastle disease virus
30. Expression of complement components of the alternative pathway by glioma cell lines
31. Expression of the complement classical pathway by human glioma in culture. A model for complement expression by nerve cells
32. Complement expression in human brain. Biosynthesis of terminal pathway components and regulators in human glial cells and cell lines
33. Complement regulatory protein expression by a human oligodendrocyte cell line: Cytokine regulation and comparison with astrocytes
34. Complement gene expression in neuroblastoma and astrocytoma cell lines of human origin
35. Neuronal expression of mRNAs for complement proteins of the classical pathway in Alzheimer brain
36. Neurons express proteins of the classical complement pathway in Alzheimer disease
37. Complement activation on human neuroblastoma cell lines in vitro: Route of activation and expression of functional complement regulatory proteins
38. Somatostatin receptors are expressed by immature cerebellar granule cells: Evidence for a direct inhibitory effect of somatostatin on neuroblast activity
39. Cleavage of structural proteins during assembly of the head of bacteriophage T4
40. Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: Procedure and some applications
41. Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease
42. Human complement factor H: Expression of an additional truncated gene product of 43 kDa in human liver
43. Truncated forms of human complement factor H
44. Complement C5a anaphylatoxin fragment causes apoptosis in TGW neuroblastoma cells
45. Complement anaphylatoxin receptors on neurons: New tricks for old receptors?