Benzo(a)pyrene diolepoxide-haemoglobin and albumin adducts at low levels of benzo(a)pyrene exposure

Biomarkers

Volumn 5, Issue 4, 2000, Pages 245-251

  Pastorelli, Roberta ^a   Guanci, Marco ^a   Cerri, Annalisa ^a   Minoia, Claudio ^b   Carrer, Paolo ^c   Negri, Eva ^a   Fanelli, Roberto ^a   Airoldi, Luisa ^a  

^a MARIO NEGRI INSTITUTE FOR PHARMACOLOGICAL RESEARCH   (Italy)

^b IRCCS   (Italy)

^c Ist Ric Farmacologiche Mario Negri ^*

Author keywords

Albumin; Benzo(a)pyrene diolepoxide adducts; Haemoglobin; Urban population

Indexed keywords

ALBUMIN; BENZO[A]PYRENE; BIOLOGICAL MARKER; DIHYDROXYBENZO[A]PYRENE OXIDE; HEMOGLOBIN;

ADULT; AIR SAMPLING; ARTICLE; BIOLOGICAL MONITORING; ENVIRONMENTAL EXPOSURE; FEMALE; GAS CHROMATOGRAPHY; HUMAN; MALE; MASS SPECTROMETRY; URBAN POPULATION;

EID: 0033879541     PISSN: 1354750X     EISSN: None     Source Type: Journal    
DOI: 10.1080/135475000413791     Document Type: Article

References (25)

1. CECINATO, A., BRANCALEONI, E., BRACHETTI, A. and CICCIOLI, P. 1993, Idrocarburi policiclici aromatici nell'atmosfera milanese. In Atti: Giornata di Studio Inquinamento Chimico e Fotochimico in Aree della Lombardia, Saronno, M. Maugeri' ed. (Saronno: Biblioteca Civica), pp. 54-65.
2. CREBELLI, R., FUSELLI, S., TURRIO BALDASSARRI, L., ZIEMACKI, G., CARERE, A. and BENIGNI, R. 1995, Genotoxicity of urban air particulate matter: correlations between mutagenicity data, airborne micropollutants, and meteorological parameters. International Journal of Environmental Health Research, 5, 19-34.
3. FERREIRA M. JR, TAS, S., DELL'OMO, M., GOORMANS, G., BUCHET, J. P. and LAUWERYS, R. 1994, Determinants of benzo(a)pyrenediol epoxide adducts to haemoglobin in workers exposed to polycyclic aromatic hydrocarbons. Occupational and Environmental Medicine, 51, 451-455.
4. GELBOIN, H.V. 1980, Benzo[a]pyrene metabolism, activation and carcinogenesis: role and regulation of mixed-function oxidases and related enzymes. Physiological Reviews, 60, 1107-1166.
5. GERDE, P., MUGGENBURG, B. A., THORNTON-MANNING, R., LEWIS, J. L., PYON, K. H. and DAHL, A. R. 1997, Benzo(a)pyrene at an environmentally relevant dose is slowly absorbed by, and extensively metabolized in, trachéal epithelium. Carcinogenesis, 18, 1825-1832.
6. LEWTAS, J., WALSH, D., WILLIAMS, R. and DOBIAS, L. 1997, Air pollution exposure-DNA adduct dosimetry in humans and rodents: evidence for non-linearity at high doses. Mutation Research, 378, 51-63.
7. LIOY, P. L., WALDMAN, J. M., GREENBERG, A., HARKOV, R. and PIETARINEN, C. 1988, The Total Human Environmental Exposure Study (THEES) to benzo[a]pyrene: comparison of the inhalation and food pathways. Archives of Environmental Health, 43, 304-312.
8. LODOVICI, M., DOLARA, P., CASALINI, C., CIAPPELLANO, S. and TESTOLIN, G. 1995, Polycyclic aromatic hydrocarbon contamination in the Italian diet. Food Additives and Contaminants, 12, 703-713.
9. MERLO, F., ANDREASSEN, A., WESTON, A., PAN, C-F., HAUGEN, A., VALERIO, F., REGGIARDO, G., FONTANA, V., GARTE, S., PUNTONI, R. and ABBONDANDOLO, A. 1998, Urinary excretion of 1-hydroxypyrene as a marker for exposure to urban air levels of polycyclic aromatic hydrocarbons. Cancer Epidemiology Biomarkers and Prevention, 7, 147-155.
10. MINOLA, C., MAGNAGHI, S., MICOLI, G., FIORENTINO, M. L., TURCI, R., ANGELERI, S. and BERRI, A. 1997, Determination of environmental reference concentration of six PAHs in urban areas (Pavia, Italy). Science of the Total Environment, 198, 33-41.
11. NAYLOR, S., GAN, L.-S., DAY, B. W., PASTORELLI, R., SKIPPER, P. L. and TANNENBAUM, S. R. 1990, Benzo[a]pyrene diol epoxide adduct formation in mouse and human hemoglobin: physicochemical basis for dosimetry. Chemical Research in Toxicology, 3, 111-117.
12. OMLAND, O., SHERSON, D., HANSEN, A. M., SIGSGAARD, T., AUTRUP, H. and OVERGAARD, E. 1994, Exposure of iron foundry workers to polycyclic aromatic hydrocarbons: benzo(a)pyrene-albumin adducts and 1-hydroxypyrene as biomarkers for exposure. Occupational and Environmental Medicine, 51, 513-518.
13. PASTORELLI, R., RESTANO, J., GUANCI, M., MARAMONTE, M., MAGAGNOTTI, C., ALLEVI, R., LAURI, D., FANELLl, R. and AIROLDI, L. 1996, Hemoglobin adducts of benzo[a]pyrene diolepoxide in newspaper vendors: association with traffic exhaust. Carcinogenesis, 17, 2389-2394.
14. PASTORELLI, R., GUANCI, M., CERRI, A., NEGRI, E., LA VECCHIA, C., FUMAGALLI, F., MEZZETTI, M., CAPPELLI, R., PANIGALLI, T., FANELLI, R. and AIROLDI, L. 1998, Impact of inherited polymorphisms in glutathione S-transferase M1, microsomal epoxide hydrolase, cytochrome P450 enzymes on DNA and blood protein adducts of benzo(a)pyrene-diolepoxide. Cancer Epidemiology Biomarkers and Prevention, 7, 703-709.
15. PASTORELLI, R., GLANCI, M., RESTANO, J., BERRI, A., MICOLI, G., MINOIA, C., ALCINI, D., CARRER, P., NEGRI, E., LA VECCHIA, C., FANELLI, R. and AIROLDI L, 1999a, Seasonal effect on atmospheric pyrene, urinary 1-hydroxypyrene and benzo(a)pyrene diolepoxide-hemoglobin adducts in the general population. Cancer Epidemiology Biomarkers and Prevention, 8, 561-565.
16. PASTORELLI, R., CERRI, A., DELL'OMO, M., MUZI, G. and AIROLDI, L. 1999b, Biomarkers of genetic susceptibility and polycyclic aromatic hydrocarbons exposure in graphite electrode producing plant workers. Proceedings of the American Association for Cancer Reserach, 40, 242.
17. PHILLIPS, D. H. 1999, Polycyclic aromatic hydrocarbons in the diet. Mutation Research, 443, 139-147.
18. SANTELLA, R. M., HEMMINKI, K., TANG, DE-L., PAIK, M., OTTMAN, R., YOUNG, T. L., SAVELA, K., VODICKOVA, L., DACKEY, C., WHYATT, R. and PERERA, F.P. 1993, Polycyclic aromatic hydrocarbon-DNA adducts in white blood cells and urinary 1-hydroxypyrene in foundry workers. Cancer Epidemiology Biomarkers and Prevention, 2, 59-62.
19. TANNENBAUM, S. R., SKIPPER, P. L., WISHNOK, J. S., STILLWELL, W. G., DAY, B. W. and TAGHIZADEH, K. 1993, Characterization of various classes of protein adducts. Environmental Health Perspectives, 99, 51-55.
20. TAS, S., BUCHET, J. P. and LAUWERYS, R. 1994, Determinants of benzo[a]pyrene diol epoxide adducts to albumin in workers exposed to polycyclic aromatic hydrocarbons. International Archives of Occupational and Environmental Health, 66, 343-348.
21. VAN DE WIEL, J. A. G., FIJNEMAN, P. H. S., DUIJF, C. M. P., ANZION, R. B. M., THEUWS, J. L. G. and Bos, R. P. 1993, Excretion of benz[a]pyrene and metabolites in urine and feces of rats: influence of route of administration, sex, and long-term ethanol tratment. Toxicology, 80, 103-115.
22. VlAU, C. and CARRIER, G. 1995, Kinetics of hemoglobin and albumin adducts in rabbits subchronically exposed to benzo[a]pyrene. Fundamental and Applied Toxicology, 24, 140-144.
23. VIAU, C., MERCIER, M. and BLONDIN, O. 1993, Measurement of hemoglobin and albumin adducts of benzo(a)pyrenediolepoxide and their rate of elimination in the female Sprague-Dawley rat. Archives of Toxicology, 67, 468-472.
24. WALDMAN, J. M., LIOY, P. L., GREENBERG, A. and BUTLER, J. P. 1991, Analysis of human exposure to benzo[a]pyrene via inhalation and food ingestion in the Total Human Environmental Exposure Study (THEES). Journal of Exposure Analysis and Environmental Epidemioogy, 1, 193-225.
25. WORLD HEALTH ORGANIZATION, 1983, Polynuclear aromatic compounds, Part 1, Chemicals, environmental and experimental data, In Evaluation of Carcinogenic Risk of Chemicals to Humans, Vol. 32, IARC Monographs (Lyon: IARC).