Molecular basis of pathogenicity in Blastomyces dermatitidis: The importance of adhesion

Current Opinion in Microbiology

Volumn 3, Issue 4, 2000, Pages 339-343

  Klein, Bruce S ^a  

^a UNIVERSITY OF WISCONSIN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADHESIN; FUNGAL PROTEIN; GLUCAN; VACCINE;

BLASTOMYCES DERMATITIDIS; BLASTOMYCOSIS; CELL ADHESION; CELL WALL; GENE TARGETING; GENETIC MANIPULATION; HUMAN; IMMUNITY; KNOCKOUT GENE; MOLECULAR BIOLOGY; NONHUMAN; PATHOGENICITY; PROTEIN EXPRESSION; REVIEW; VACCINATION; VIRULENCE;

EID: 0033875577     PISSN: 13695274     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1369-5274(00)00100-4     Document Type: Review

References (33)

1. Lipid content of four strains of Blastomyces dermatitidis of different mouse virulence
2. Cell wall composition of two strains of Blastomyces dermatitidis exhibiting differences in virulence for mice
3. Histologic reaction to cell walls of an avirulent and a virulent strain of Blastomyces dermatitidis
4. Spontaneous mutant of Blastomyces dermatitidis attenuated in virulence for mice
5. Mechanisms of fungal pathogenicity correlation of virulence in vivo, susceptibility to killing by polymorphonuclear neutrophils in vitro, and neutrophil superoxide anion induction among Blastomyces dermatitidis isolates
6. Cell walls from avirulent variants of Histoplasma capsulatum lack α-1,3-glucan
7. Isolation and wall analysis of dimorphic mutants of Paracoccidiodes brasiliensis
8. Paracoccidiodes brasiliensis: Cell wall structure and virulence
9. Altered expression of α-(1,3)-glucan on genetically related strains of Blastomyces dermatitidis that differ in virulence
10. Isolation, purification and radiolabeling of a novel 120 KD surface protein on Blastomyces dermatitidis yeasts to detect antibody in infected patients
11. Immunologic recognition of a 25-amino acid repeat arrayed in tandem on a major antigen of Blastomyces dermatitidis
12. Purification and characterization of the major antigen WI-1 from Blastomyces dermatitidis, yeasts, and immunological comparison with A antigen
13. WI-1, a novel 120 KD surface protein on Blastomyces dermatitidis yeast cells, is a target antigen of cell mediated immunity in human blastomycosis
14. Genomic cloning, characterization, and functional analysis of the major surface adhesin WI-1 on Blastomyces dermatitidis yeasts
15. Identification of invasin: A protein that allows enteric bacteria to penetrate cultured mammalian cells
16. Multiple β1 chain integrins are receptors for invasin, a protein that promotes bacterial penetration into mammalian cells
17. Altered expression of the surface protein WI-1 in genetically-related strains of Blastomyces dermatitidis that differ in virulence regulates recognition of yeasts in human macrophages
18. WI-1 on Blastomyces dermatitidis yeast mediates binding to human macrophage CR3(CD11b/CD18) and CD14
19. Bacterial adherence: Adhesin-receptor interactions mediating the attachment of bacteria to mucosal surfaces
20. Transforming DNA integrates at multiple sites in the dimorphic fungal pathogen Blastomyces dermatitidis
21. Targeted gene disruption reveals an adhesin indispensable for pathogenicity of Blastomyces dermatitidis
22. Consecutive inactivation of both alleles of the pim-1 proto-oncogene by homologous recombination in embryonic stem cells
23. Irreversible block of the mycelial-to-yeast phase transition of Histoplasma capsulatum
24. Mycelial to yeast phase transitions of dimorphic fungi Blastomyces dermatitidis and Paracoccidiodes brasiliensis
25. Yeast phase specific expression and regulation of WI-1, an essential virulence determinant of Blastomyces dermatitidis
26. Immunogenicity and protective efficacy of the WI-1 adhesin of Blastomyces dermatitidis
27. Vaccination against experimental murine blastomycosis using a live, attenuated strain of recombinant Blastomyces dermatitidis lacking the WI-1 adhesin
28. Antigenicity and immunogenicity of the cell wall and cell membrane of Histoplasma capsulatum yeast cells
29. Protective efficacy of a 62-kilodalton antigen, HIS-62, from the cell wall and cell membrane of Histoplasma capsulatum yeast cells
30. Cellular and molecular mechanisms of vaccine immunity to experimental blastomycosis conferred by a live, attenuated strain of Blastomyces dermatitidis lacking the WI-1 adhesin
31. Factors involved in regulating primary and secondary immunity to infection with Histoplasma capsulatum: TNF-α plays a critical role in maintaining secondary immunity in the absence of IFN-γ
32. Blockade of endogenous TNF-α exacerbates primary and secondary pulmonary histoplasmosis by differential mechanisms
33. Complex requirements for nascent and memory immunity in pulmonary histoplasmosis