Enzyme kinetics and inhibition of nimodipine metabolism in human liver microsomes

Acta Pharmacologica Sinica

Volumn 21, Issue 8, 2000, Pages 690-694

  Liu, X Q ^a   Ren, Y L ^a   Qian, Z Y ^a   Wang, G J ^a  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

Cytochrome P 450; Kinetics; Liver microsomes; Metabolism; Nimodipine

Indexed keywords

NIMODIPINE;

ARTICLE; DRUG METABOLISM; ENZYME KINETICS; HUMAN; HUMAN TISSUE; LIVER METABOLISM; LIVER MICROSOME;

CALCIUM CHANNEL BLOCKERS; HUMANS; KETOCONAZOLE; MICROSOMES, LIVER; NIMODIPINE; TROLEANDOMYCIN;

EID: 0033870265     PISSN: 02539756     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (12)

1. Nimodipine: A review of its pharmacokinetic and pharmacodynamic properties, therapeutic potential in cerebrovascular diseases
2. Efficacy of nimodipine in cerebral ischemia or hemorrhage
3. Differential effects of 1,4-dihydropyridine calcium channel blockers: Therapeutic implications
4. Pharmacokinetics and metabolism of calcium blocking agents nifedipine, nitrendipine and nimodipine
5. Clinical pharmacokinetics od nimodipine in normal and impaired renal function
6. Drug metabolism in human liver in vitro: Establishment of a human liver bank
7. Protein measurement with Folin phenol reagent
8. Gas and liquid chromatographic analyses of nimodipine calcium antagonist in blood plasma and cerebospinal fluid
9. Cytochrome P50 inhibitors evaluation of specificities in the in vitro metabolism of therapeutic agents by human liver microsomes
10. Nimodipine: Synthesis and metabolic phatway
11. Variability of nimodipine pharmacokinetics in healthy Chinese male
12. Cytochrome P450 2C9 catalyzes indomethacin O-demethylation in human liver microsomes