Grepafloxacin against penicillin-resistant pneumococci in the rabbit meningitis model

Journal of Antimicrobial Chemotherapy

Volumn 46, Issue 2, 2000, Pages 249-253

  Gerber, Cynthia M ^a   Tovar, Luis ^b   Cottagnoud, Marianne ^a   Neftel, Klaus A ^b   Täuber, Martin G ^c   Cottagnoud, Philippe ^b  

^a Spital Netz Bern   (Switzerland)

^b UNIVERSITY OF BERN   (Switzerland)

^c UNIVERSITY OF BERN   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

CEFTRIAXONE; GREPAFLOXACIN; PENICILLIN G; QUINOLINE DERIVED ANTIINFECTIVE AGENT; VANCOMYCIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BACTERIAL MENINGITIS; BACTERICIDAL ACTIVITY; COMPARATIVE STUDY; CONTROLLED STUDY; DRUG MEGADOSE; DRUG POTENTIATION; IN VITRO STUDY; MINIMUM INHIBITORY CONCENTRATION; MONOTHERAPY; NONHUMAN; PENICILLIN RESISTANCE; RABBIT; STREPTOCOCCUS PNEUMONIAE;

EID: 0033869853     PISSN: 03057453     EISSN: None     Source Type: Journal    
DOI: 10.1093/jac/46.2.249     Document Type: Article

References (27)

1. Trends in the antimicrobial susceptibility of bacterial respiratory tract pathogens-findings of the Alexander Project 1992-1996
2. Resistance to penicillin and cephalosporin and mortality from severe pneumococcal pneumonia in Barcelona, Spain
3. The challenge of penicillin-resistant Streptococcus pneumoniae meningitis: Current antibiotic therapy in the 1990s
4. Ceftriaxone failure in meningitis caused by Streptococcus pneumoniae with reduced susceptibility to beta-lactam antibiotics
5. Cephalosporin treatment failure in penicillin- and cephalosporin-resistant Streptococcus pneumoniae meningitis
6. In vitro activity of fluoroquinolones against gram-positive bacteria
7. Activity of CP99,219 compared with DU-6859a, ciprofloxacin, ofloxacin, levofloxacin, lomefloxacin, tosufloxacin, sparfloxacin and grepafloxacin against penicillin-susceptible and -resistant pneumococci
8. Activity of DU-6859a, ciprofloxacin, ofloxacin, levofloxacin, sparfloxacin and OPC-17116 against 112 penicillin-susceptible and -resistant penumococci
9. Antibacterial activities of grepafloxacin, ciprofloxacin, ofloxacin and fleroxacin
10. Randomized, double-blind study of grepafloxacin versus amoxycillin in patients with acute bacterial exacerbations of chronic bronchitis
11. Effectiveness of short-course therapy (5 days) with grepafloxacin in the treatment of acute bacterial exacerbations of chronic bronchitis
12. Randomized, double-blind, comparative study of grepafloxacin and amoxycillin in the treatment of patients with community-acquired pneumonia
13. Effect of probenecid on cerebrospinal fluid concentrations of penicillin and cephalosporin derivatives
14. Microbioassay of antimicrobial agents
15. A study of the genetic material determining an enzyme activity in Pneumococcus
16. Management of infections due to antibiotic-resistant Streptococcus pneumoniae
17. Trovafloxacin in treatment of rabbits with experimental meningitis caused by high-level penicillin-resistant Streptococcus pneumococci
18. Trovafloxacin in combination with vancomycin against penicillin-resistant pneumococci in the rabbit meningitis model
19. Wirksamkeit und Vertraglichkeit von Grepafloxacin in der Praxis
20. Pharmacokinetics of grepafloxacin
21. Pharmacokinetics and pharmacodynamics of oral grepafloxacin in patients with acute bacterial exacerbations of chronic bronchitis
22. Evaluation of antimicrobial regimens for treatment of experimental penicillin- and cephalosporin-resistant pneumococcal meningitis
23. A critical evaluation of vancomycin for treatment of bacterial meningitis
24. Vancomycin therapy in bacterial meningitis
25. Evaluation of cefepime alone and in combination with vancomycin against penicillin-resistant pneumococci in the rabbit meningitis model and in vitro
26. Grepafloxacin: A review of its safety profile based on clinical trials and postmarketing surveillance
27. Fluoroquinolone toxicity profiles: A review focusing on newer agents