Displacement currents associated with the insertion of Alzheimer disease amyloid β-peptide into planar bilayer membranes

Biophysical Journal

Volumn 79, Issue 2, 2000, Pages 934-944

  Vargas, J ^a   Alarcon J M ^a   Rojas, E ^a,b,c  

^a UNIVERSITY OF CHILE   (Chile)

^b NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

^c SANSUM DIABETES RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID BETA PROTEIN; PHOSPHOLIPID DERIVATIVE;

ALZHEIMER DISEASE; AMINO ACID SEQUENCE; ARTICLE; BILAYER MEMBRANE; DIPOLE; MEMBRANE CURRENT; MEMBRANE POTENTIAL; MOLECULAR SIZE; PROTEIN LIPID INTERACTION; SEQUENCE HOMOLOGY; STEADY STATE;

EID: 0033869674     PISSN: 00063495     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-3495(00)76348-X     Document Type: Article

References (9)

1. Alvarez, O., and R. Latorre. 1978. Voltage-dependent capacitance in lipid bilayers made from monolayers. Biophys. J. 21:1-17.
2. Arispe, N., H. B. Pollard, and E. Rojas. 1993a. Giant multilevel cation channels formed by Alzheimer disease amyloid beta-protein (AβP-[1-40]) in bilayer membranes. Proc. Natl. Acad. Sci. USA. 90:10573-10577.
3. 2+-channel hypothesis for neuronal death in Alzheimer disease. Mol. Cell. Biochem. 140:119-125.
4. Arispe, N., E. Rojas, and H. B. Pollard. 1993b. Alzheimer disease amyloid β-protein forms calcium channels in bilayer membranes: blockade by thrometamine and aluminum. Proc. Natl. Acad. Sci. USA. 90:567-571.
5. Armstrong, C. M., and F. Bezanilla. 1974. Charge movement associated with the opening and closing of the activation of the Na channels. J. Gen. Physiol. 63:533-552.
6. Bainbridge, G., Mobasheri, H., Armstrong, G. A., Lea, E. J. A., and J. H. Lakey. 1998. Voltage-gating of Escherichia coli porin: a cystine-scanning mutagenesis study of loop 3. J. Mol. Biol. 275:171-176.
7. Beffert, U., M. Danik, P. Krzywkowski, C. Ramassamy, F. Berrada, and J. Poirier. 1998. The neurobiology of apoproteins and their receptors in the CNS and Alzheimer's disease. Brain. Res. Rev. 27:119-142.
8. Carrell, R. W., and D. A. Lomas. 1997. Conformational disease. Lancet. 350:134-138.
9. Chanturiya, A. N., and H. V. Nikoloshina. 1994. Correlation between changes in membrane capacitance induced by changes in ionic environment and the conductance of channels incorporated into bilayer lipid membranes. J. Membr. Biol. 137:71-77.