Antithrombotic effect of rutaecarpine, an alkaloid isolated from Evodia rutaecarpa, on platelet plug formation in in vivo experiments

British Journal of Haematology

Volumn 110, Issue 1, 2000, Pages 110-115

  Sheu, J R ^a   Hung, W C ^a   Wu, C H ^a   Lee, Y M ^b   Yen, M H ^b  

^a TAIPEI MEDICAL UNIVERSITY   (Taiwan)

^b NATIONAL DEFENSE MEDICAL CENTER   (Taiwan)

Author keywords

Arterial thrombosis; Fluorescein sodium; Occlusion time; Platelet plug; Rutaecarpine

Indexed keywords

ALKALOID; EVODIA FRUIT; FLUORESCEIN SODIUM; HEPARIN; PLANT EXTRACT; RUTAECARPINE; TAECARPINE; UNCLASSIFIED DRUG;

ANIMAL MODEL; ANTICOAGULATION; ARTERY THROMBOSIS; ARTICLE; BLEEDING TIME; BLOOD PRESSURE; CONTROLLED STUDY; DRUG EFFECT; DRUG STRUCTURE; LUNG EMBOLISM; MOUSE; NONHUMAN; PRIORITY JOURNAL; RAT;

ADENOSINE DIPHOSPHATE; ALKALOIDS; ANIMALS; ASPIRIN; BLEEDING TIME; BLOOD PRESSURE; DRUGS, CHINESE HERBAL; FLUORESCEIN; MICE; MICE, INBRED ICR; PLATELET AGGREGATION; PLATELET AGGREGATION INHIBITORS; PULMONARY EMBOLISM; RATS; RATS, SPRAGUE-DAWLEY;

EID: 0033869572     PISSN: 00071048     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2141.2000.01953.x     Document Type: Article

References (19)

1. Smooth muscle and thrombus thresholds to unipolar stimulation of small blood vessels
2. In vivo and in vitro studies on the mechanism of the cardiovascular effect of Wu-Chu-Yu (Evodiae fructus)
3. The mechanism of the vasodilator effect of rutaecarpine, an alkaloid isolated from Evodiae rutaecarpa
4. Pharmacological studies on Chinese herbs. 3. Analgesic effect of 27 Chinese drugs in mice
5. Platelet glycoprotein IIb/IIIa antagonists
6. The Canadian American Ticlopidine Study (CATS) in thromboembolic stroke
7. A randomized trial comparing ticlopidine hydrochloride with aspirin for the prevention of stroke in high-risk patients
8. Measure of the platelet response to laser induced microvascular injury; Ultrastructural studies
9. High-performance liquid chromatographic determination of rutaecarpine in rat plasma: Application to a pharmacokinetic study
10. Pharmacological studies of Chinese herbs. 9. Pharmacological effects of Evodiae fruetus
11. The bleeding time does not predict surgical bleeding
12. Platelet thrombosis induced by adenosine diphosphate in the rat
13. A critical reappraisal of the bleeding time
14. Platelet thrombus induced in vivo by filtered light and fluorescent dye in mesenteric microvessels of the rat
15. Hemodynamic at stenosis formed by growing platelet thrombi in mesenteric microvasculature of rat
16. Mechanism of inhibition of platelet aggregation by rutaecarpine, an alkaloid isolated from Evodiae rutaecarpa
17. The antiplatelet activity of rutaecarpine, an alkaloid isolated from Evodia rutaecarpa, is mediated through inhibition of phospholipase C
18. Effect of ADP-utilizing enzymes on the arterial bleeding time in rats and rabbits