Studies on the carcinogenicity of potassium iodide in F344 rats

Food and Chemical Toxicology

Volumn 38, Issue 9, 2000, Pages 773-781

  Takegawa, K ^a   Mitsumori, K ^a   Onodera, H ^a   Shimo, T ^a   Kitaura, K ^a   Yasuhara, K ^a   Hirose, M ^a   Takahashi, M ^a  

^a NATIONAL INSTITUTE OF HEALTH SCIENCES   (Japan)

Author keywords

N bis(2 hydroxypropyl)nitrosamine; Salivary gland; Thyroid

Indexed keywords

BIS(2 HYDROXYPROPYL)NITROSAMINE; POTASSIUM IODIDE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CARCINOGENICITY; CHRONIC TOXICITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; FEMALE; MALE; NONHUMAN; RAT; SALIVARY GLAND CARCINOMA; SQUAMOUS CELL CARCINOMA; THYROID TUMOR; TOXICOKINETICS;

ANIMALS; CARCINOGENICITY TESTS; CARCINOGENS; CARCINOMA, SQUAMOUS CELL; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; MALE; POTASSIUM IODIDE; RATS; RATS, INBRED F344; SALIVARY GLAND NEOPLASMS; THYROID NEOPLASMS;

ANIMALIA;

EID: 0033869350     PISSN: 02786915     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0278-6915(00)00068-5     Document Type: Article

References (17)

1. Capen C. C. (1996) Toxic responses of the endocrine system. In Casarett and Doull's Toxicology: The Basic Science of Poisons, ed. C. D. Klaassen, M. O. Amdur and J. Doull. 5th edn, pp. 617-640. McGraw-Hill, New York.
2. Collins W.T. Jr., Capen C.C. Ultrastructural and functional alterations in thyroid glands of rats produced by polychlorinated biphenyls compared with the effects of iodide excess and deficiency, and thyrotropin and thyroxine administration. Virchows Archiv B, Cell Pathology. 33:1980;213-231.
3. Correa P., Welsh R.A. The effect of excess iodine intake on the thyroid gland of the rat. Archives of Pathology. 70:1960;247-251.
4. Kanno J., Onodera H., Furuta K., Maekawa A., Kasuga T., Hayashi Y. Tumor-promoting effects of both iodine deficiency and iodine excess in the rat thyroid. Toxicologic Pathology. 20:1992;226-235.
5. Laurberg P., Boye N. Inhibitory effect of various radiographic contrast agents on secretion of thyroxine by the dog thyroid and on peripheral and thyroidal deiodination of thyroxine to triiodothyronine. Journal of Endocrinology. 112:1987;387-390.
6. Maekawa A., Kurokawa Y., Takahashi M., Kokubo T., Ogiu T., Onodera H., Tanigawa H., Ohno Y., Furukawa F., Hayashi Y. Spontaneous tumors in F-344/DuCrj rats. Gann. 74:1983;365-372.
7. Maekawa A., Onodera H. Spontaneous neoplastic and non-neoplastic lesions in ACI, F344, Wistar and Donryu rats. Journal of Pathology. 1:1988;13-17.
8. Maita K., Hirano M., Harada T., Mitsumori K., Yoshida A., Takahashi K., Nakashima N., Kitazawa T., Enomoto A., Inui K., Shirasu Y. Spontaneous tumors in F344/DuCrj rats from 12 control groups of chronic and oncogenicity studies. Journal of Toxicological Sciences. 12:1987;111-126.
9. Morton M.E., Chaikoff I.L., Rosenfeld S. Inhibiting effect of inorganic iodide on the formation in vitro of thyroxine and diiodothyrosine by surviving thyroid tissue. Journal of Biological Chemistry. 154:1944;381-387.
10. Ohshima M., Ward J.M. Dietary iodine deficiency as a tumor promotor and carcinogen in male F344/NCr rats. Cancer Research. 46:1986;877-883.
11. Pennington J.A. A review of iodine toxicity reports. Journal of the American Dietetic Association. 90:1990;1571-1581.
12. Ruiz M., Ingbar S.H. Effect of erythrosine (2′,4′,5′,7′-tetraiodofluorescein) on the metabolism of thyroxine in rat liver. Endocrinology. 110:1983;1613-1617.
13. Takegawa K., Mitsumori K., Onodera H., Yasuhara K., Kitaura K., Shimo T., Takahashi M. Induction of squamous cell carcinomas in the salivary glands of rats by potassium iodide. Japanese Journal of Cancer Research. 89:1998;105-109.
14. The 30th Meeting of the Joint FAO/WHO Expert Committee on Food Additives, Rome, 2-11. June 1986 (1987) Erythrosine. In Toxicological Evaluation of Certain Food Additives and Contaminants, WHO Food Additive Series: 21, pp. 81-109. Cambridge University Press, Cambridge.
15. Wolff J. Iodide goitre and the pharmacologic effects of excess iodide. American Journal of Medicine. 47:1969;101-124.
16. Wolff J., Chaikoff L. Plasma inorganic iodide as a homeostatic regulator of thyroid function. Journal of Biological Chemistry. 174:1948;555-564.
17. Wolff J., Chaikoff R.C., Goldberg R.C., Meier J.R. The temporary nature of the inhibitory action of excess iodide on organic iodine synthesis in the normal thyroid Endocrinology. 45:1949;504-513.