Photodynamic action of meta-tetrahydroxyphenylchlorin (mTHPC) on an ovarian cancer cell line

Anticancer Research

Volumn 20, Issue 4, 2000, Pages 2647-2652

  Gharehbaghi, Kamran ^a   Kubin, Andreas ^b   Grusch, Michael ^c   Gharehbaghi Schnell, Elisabeth ^c   Wierrani, Franz ^a   Jayaram, Hiremagalur N ^d   Grunberger, Werner ^a   Szekeres, Thomas ^c  

^a KRANKENANSTALT RUDOLFSTIFTUNG   (Austria)

^b LUDWIG BOLTZMANN INSTITUTE FOR LUNG VASCULAR RESEARCH   (Austria)

^c UNIVERSITY OF VIENNA   (Austria)

^d INDIANA UNIVERSITY   (United States)

Author keywords

Meta tetrahydroxyphenylchlorin (mTHPC); Necrosis; Ovarian cell line

Indexed keywords

ANTINEOPLASTIC AGENT; CISPLATIN; META TETRAHYDROXYPHENYLCHLORIN; PACLITAXEL; PHOTOSENSITIZING AGENT; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CELL DEATH; CELL LEVEL; CONTROLLED STUDY; DRUG CYTOTOXICITY; HUMAN; HUMAN CELL; LIGHT; OVARY CANCER; PHOTODYNAMIC THERAPY; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL;

ANTINEOPLASTIC AGENTS; APOPTOSIS; CISPLATIN; FEMALE; HUMANS; MESOPORPHYRINS; NECROSIS; OVARIAN NEOPLASMS; PACLITAXEL; PHOTOCHEMOTHERAPY; TUMOR CELLS, CULTURED;

EID: 0033868749     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (18)

1. Bock G and Harnett S: Photosensitizing Compounds: Their Chemistry, Biology and Clinical Use. Ciba Foundation Symposium 146, John Wiley & Sons, Chichester, UK., 1989.
2. Ash DV and Brown SB: New Drugs and Future Developments in Photodynamic Therapy. Eur J Cancer 29A: 1781-1783, 1993.
3. Hillerersberg R, Kort WJ and Wilson JHP: Current Status of Photodynamic Therapy in Oncology. Drugs 48: 510-527, 1994.
4. Kessel D: Sites of photosensitization by derivates of hematoprophyrin. Photochem Photobiol 44: 489-494, 1986.
5. Ochsner M: Photophysical and photobiological processes in the photodynamic therapy of tumors. J Photochem Photobiol B Biology 39: 1-18, 1997.
6. Gomer CJ, Rucker N, Ferrario A and Wong S: Properties and applications of photodynamic therapy. Radiat Res 120: 1-18, 1989.
7. Nseyo UO, Shumaker B, Klein EA and Sutherland K: Photodynamic therapy using porfimer sodium as an alternative to cystectomy in patients with refractory transitional cell carcinoma in situ of the bladder. Bladder Photofrin. J Urol 160: 39-44, 1998.
8. Bonnett R, and Berenbaum MC: Porphyrin as sensitizers. In: Ciba Foundation Symposium 146 (eds.), Photosensitising compounds: their chemistry, biology and clinical use, pp.40-53, John Wiley Chichester, 1989.
9. Nambisan RN, Karakousis CP, Holyoke ED and Dougherty TJ: Intraoperative photodynamic therapy for retroperitoneal sarcomas. Cancer 61: 1248-1252, 1988.
10. Ris HB, Altermatt HJ, Inderbitzi, R, Hess R, Nachbur B, Stewart JCM, Bonnet R, MC and Althaus U: Photodynamic therapy with chlorines for diffuse malignant mesothelioma: initial results. BritJ Cancer 64: 1116-1120, 1991.
11. Mang TS, Allison R, Hewson G, Snider W, Moskowitz R: A phase II/IIIclinical study of tin ethyl etiopurpurin (Purlytin)-induced photodynamic therapy for the treatment of recurrent cutaneous metastatic breast cancer. Cancer J Sci Am 4: 378- 384, 1998.
12. Rossi FM, Campell DL., Pottier RH, Kennedy JC and Gudgin EFDickson: In vitro studies on the potential use of aminolaevulinic acid mediated photodynamic therapy for gynaecological malignancies. Br J Cancer 74: 881-887, 1996.
13. Delany TF, Sindelar WF, Tochner Z, Smith PD, Friauf WS, Thomas G, Dachowski L, Cole JW, Steinberg SM and Glatstein E: Phase I study of debulking surgery and photodynamic therapy for siddeminated intraperitoneal tumors. Int J Radiat Oncol Biol Phys 25: 445-457, 1993.
14. Wierrani F, Fiedler DM, Grin W, Henry M, Dienes E, Gharehbaghi K, Krammer B and Grunberger W: Clinical effect of meso-tetra-hydroxyphenylchlorine based photodynamic therpy in reccurent carcinoma of the ovary: preliminary results. Brit J Obstet Gynecol 104: 376-378, 1997.
15. Finlay GJ, Wilson WR and Baguely BC: Comparison of in vitro activity of cytotoxic drugs towards human carcinoma and leukemic cell lines. Europ J Cancer Clin Oncol 22: 655-662, 1986.
16. Ausubel FM, Brent R, Kingston RE, Moore DD, Sidman J G, Smith JA and Struhl K: Current Protocols in Molecular Biology. Greene Publishing Associates and John Wiley & Sons, Inc., NY 1994.
17. Darzynkiewicz Z, Xun Li and Jianping G: . Assays of cell viability. Discrimination of cells dying by apoptosis. Methods in Cell Biology: Flow cytometry, 2nd Edition. Z. Darzynkiewicz, H.A. Crissman and J.R. Robinson, eds. Academic Press, 1994.
18. Ozols RF and Young RC: Ovarian cancer: where to next? Semin Oncol 18: 307-310, 1991.