Twenty-seven years studying the human neurotoxicity of methylmercury exposure

Environmental Research

Volumn 83, Issue 3, 2000, Pages 275-285

  Myers, G J ^a   Davidson, P W ^a   Cox, C ^a   Shamlaye, C ^b   Cernichiari, E ^a   Clarkson, T W ^a  

^a UNIVERSITY OF ROCHESTER SCHOOL OF MEDICINE AND DENTISTRY   (United States)

^b MINISTRY OF HEALTH   (Seychelles)

Author keywords

Child development; Clinical research; Mercury; Methyl mercury; Seychelles

Indexed keywords

METHYLMERCURY;

DIET; FISH; HEALTH RISK; MEDICAL GEOGRAPHY; METHYLMERCURY; POLLUTION EXPOSURE;

CHILD DEVELOPMENT; CLINICAL RESEARCH; CONFERENCE PAPER; DIETARY INTAKE; DOSIMETRY; ENVIRONMENTAL EXPOSURE; FISH; HUMAN; IRAQ; MATERNAL NUTRITION; NEUROTOXICITY; PRENATAL EXPOSURE; PRIORITY JOURNAL; SEYCHELLES;

ANIMALIA;

EID: 0033868426     PISSN: 00139351     EISSN: None     Source Type: Journal    
DOI: 10.1006/enrs.2000.4065     Document Type: Article

References (88)

1. Al-Damluji S. F. Organomercury poisoning in Iraq: History prior to the 1971-1972 outbreak. Conference on intoxication due to alkylmercury-treated seed, Baghdad, Iraq, 9-13 September, 1974. Bull. WHO. 53:1976;11-14.
2. Al-Tikriti K., Al-Mufti A. W. An outbreak of organomercury poisoning among Iraqi farmers. Conference on intoxication due to alkylmercury-treated seed, Baghdad, Iraq, 9-13 September, 1974. Bull. WHO. 53:1976;15-21.
3. Amin-Zaki L., Elhassani S., Majeed M. A., Clarkson T. W., Doherty R. A., Greenwood M. R. Intra-uterine methylmercury poisoning in Iraq. Pediatrics. 54:1974a;587-595.
4. Amin-Zaki L., Elhassani S., Majeed M. A., Clarkson T. W., Doherty R. A., Greenwood M. R. Studies of infants postnatally exposed to methylmercury. J. Pediatr. 85:1974b;81-84.
5. Amin-Zaki L., Elhassani S., Majeed M. A., Clarkson T. W., Doherty R. A., Greenwood M. R. Prenatal methylmercury poisoning in Iraq. Proceedings of the First International Mercury Conference. II:1974c;Fabrica National de Moneda U Timbre, Madrid. p. 319-325.
6. Amin-Zaki L., Elhassani S., Majeed M. A., Clarkson T. W., Doherty R. A., Greenwood M. R., Giovanoli-Jakubczak T. Prenatal methylmercury poisoning in Iraq. Am. J. Dis. Child. 130:1976;1070-1076.
7. Amin-Zaki L., Majeed M. A., Clarkson T. W., Greenwood M. R. Methylmercury poisoning in Iraqi children: Clinical observations over two years. Br. Med. J. 1:1978;613-616.
8. Amin-Zaki L., Majeed M. A., Elhassani S. B., Clarkson T. W., Greenwood M. R., Doherty R. A. Prenatal methylmercury poisoning: Clinical observations over five years. Am. J. Dis. Child. 133:1979;172-177.
9. Amin-Zaki L., Elhassani S. B., Majeed M. A., Clarkson T. W., Doherty R. A., Greenwood M. R. Methylmercury poisoning in mothers and their suckling infants. Holmsted B., Lauwerys R., Mercier M., Roberfroid M. Mechanisms of Toxicity and Hazard Evaluation. 1980;75-78 Elsevier/North-Holland Biomedical Press, Amsterdam.
10. Amin-Zaki L., Majeed M. A., Greenwood M. R., Elhassani S. B., Clarkson T. W., Doherty R. A. Methylmercury poisoning in the Iraqi suckling infant: A longitudinal study over five years. J. Appl. Toxicol. 1:1981;210-214.
11. Axtell C. D., Myers G. J., Davidson P. W., Choi A. L., Cernichiari E., Sloane-Reeves J., Shamlaye C., Cox C., Clarkson T. W. Semiparametric modeling of age at achieving developmental milestones after prenatal exposure to methylmercury in the Seychelles Child Development Study. Environ. Health Perspect. 106:1998;559-564.
12. Bakir F., Damluji S. F., Amin-Zaki L., Murtadha M., Khalidi A., Al-Rawi N. Y., Tikriti S., Dahir H. I., Clarkson T. W., Smith J. C., Doherty R. A. Methylmercury poisoning in Iraq. Science. 181:1973;230-241.
13. Bakir F., Al-Khalidi A., Clarkson T. W., Greenwood M. R. Clinical observations on treatment of alkylmercury poisoning in hospital patients. Conference on intoxication due to alkylmercury-treated seed, Baghdad, Iraq, 9-13 September 1974. WHO, Geneva. Bull. WHO. 53:1976;87-92.
14. Bellinger D. Effect modification in epidemiologic studies of low-level neurotoxicant exposures and health outcomes. Neurotoxicol. Teratol. 22:2000;133-140.
15. Cernichiari E., Toribara T. Y., Liang L., Marsh D. O., Berlin M. W., Myers G. J., Cox C., Shamlaye C. F., Choisy O., Davidson P., Clarkson T. W. The biological monitoring of mercury in the Seychelles study. Neurotoxicology. 16:1995a;613-628.
16. Cernichiari E., Brewer R., Myers G. J., Marsh D. O., Lapham L. W., Cox C., Shamlaye C. F., Berlin M., Davidson P. W., Clarkson T. W. Monitoring methylmercury during pregnancy: Maternal hair predicts fetal brain exposure. Neurotoxicology. 16:1995b;705-710.
17. Clarkson T. W., Rothstein A. The excretion of volatile mercury by rats injected with mercuric salts. Health Phys. 10:1964;1115-1121.
18. Clarkson T. W., Rothstein A., Sutherland R. The mechanism of action of mercurial diuretics in rats: The metabolism of 203 Hg-labeled chlormerodrin. Br. J. Pharmacol. Chemother. 24:1965;1-13.
19. Clarkson T. W., Magos L. Studies on the binding of mercury in tissue homogenates. Biochem. J. 9:1966;62-70.
20. Clarkson T. W., Magos L. The effect of sodium maleate on the renal deposition and excretion of mercury. Br. J. Pharmacol. Chemother. 31:1967;560-567.
21. Clarkson T. W., Greenwood M. R. Simple and rapid determination of mercury in urine and tissues by isotope exchange. Talanta. 115:1968;54-555.
22. Clarkson T. W., Smith J. C., Bakir F. A preliminary report on a population that received a heavy exposure to methylmercury. Hemphill D. D. Trace Substances in Environmental Health. 1974;127-135 Univ. of Missouri, Columbia.
23. Clarkson T. W., Amin-Zaki L., Al-Tikriti S. An outbreak of methylmercury poisoning due to consumption of contaminated grain. Fed. Proc. 35:1976;2395-2399.
24. Clarkson T. W., Magos L., Cox C., Greenwood M. R., Amin-Zaki L., Majeed M. A., Damluji S. F. Tests of efficacy of antidotes for removal of methylmercury in human poisonings during the Iraq outbreak. J. Pharmacol. Exp. Ther. 218:1981a;74-83.
25. Clarkson T. W., Cox C., Mash D. O., Myers G. J., Al-Tikriti S., Amin-Zaki L., Dabbagh A. R. Dose-response relationships for adult and prenatal exposures to methylmercury. Berg G. G., Maillie H. D. Measurement of Risk. 1981b;111-130 Plenum, New York.
26. Clarkson T. W. Environmental contaminants in the food chain. Am. J. Clin. Nutr. 61:1995;682S-686S.
27. Cox C., Clarkson T. W., Marsh D. O., Amin-Zaki L., Tikriti S., Myers G. J. Dose-response analysis of infants prenatally exposed to methylmercury. An application of a single compartment model to single-strand hair analysis. Environ. Res. 31:1989;640-649.
28. Cox C., Marsh D. O., Myers G. J., Clarkson T. W. Analysis of data on delayed development from the 1971-1972 outbreak of methylmercury poisoning in Iraq: Assessment of influential points. Neurotoxicology. 16:1995;727-730.
29. Davidson P. W., Myers G. J., Cox C., Shamlaye C. F., Sloane-Reeves J., Cernichiari E., Marsh D., Clarkson T. W., Tanner M. A. Measuring neurodevelopmental outcomes of young children following prenatal dietary low dose methyl mercury exposures. Environ. Sci. 3:1994;55-65.
30. Davidson P. W., Myers G. J., Cox C., Shamlaye C. F., Choisy O., Sloane-Reeves J., Cernichiari E., Marsh D. O., Berlin M., Tanner M. A., Clarkson T. W. Neurodevelopmental test selection, administration and performance in the main Seychelles Child Development study. Neurotoxicology. 16:1995a;665-676.
31. Davidson P. W., Myers G. J., Cox C., Shamlaye C. F., Marsh D. O., Tanner M. A., Berlin M., Sloane-Reevesm, Cernichiari E., Choisy O., Choi A., Clarkson T. W. Longitudinal neurodevelopmental study of Seychellois children following in utero exposure to methylmercury from maternal fish ingestion: Outcomes at 19 and 29 months. Neurotoxicology. 16:1995b;677-799.
32. Davidson P. W., Myers G. J., Cox C., Axtell C., Shamlaye C., Sloane-Reeves J., Cernichiari E., Needham L., Choi A., Wang Y., Berlin M., Clarkson T. W. Effects of prenatal and postnatal methylmercury exposure from fish consumption on neurodevelopment. J. Am. Med. Assoc. 280:1998;701-707.
33. Davidson P. W., Myers G. J., Shamlaye C., Cox C., Gao P., Axtellm C., Morris D., Sloane-Reeves J., Cernichiari E., Choi A., Palumbo D., Clarkson T. W. Association between prenatal exposure to methylmercury and developmental outcomes in Seychellois children: Effect modification by social and environmental factors. Neurotoxicology. 20:1999;833-842.
34. Davidson P. W., Palumbo D., Myers G. J., Cox C., Shamlaye C. F., Sloan-Reeves J., Cernichiari E., Wilding G. E., Clarkson T. W. Neurodevelopmental outcomes of seychellois children from the pilot cohort at 108 months following prenatal exposure to methylmercury from a maternal fish diet. Environ. Sci. 2000.
35. Daviglus M. L., Stamler J., Orencia A. J., Dyer A. R., Liu K., Greenland P., Walsh M. K., Morris D., Shekelle R. B. Fish consumption and the 30-year risk of fatal myocardial infarction. N. Engl. J. Med. 336:1997;1046-1053.
36. Davis L. E., Kornfeld M., Mooney H. S., Feidler K. J., Haaland K. Y., Orrison W. W., Cernichiari E., Clarkson T. W. Methylmercury poisoning: Long-term clinical, radiological, toxicological, and pathological studies of an affected family. Ann. Neurol. 35:1994;680-688.
37. Egeland G. M., Middaugh J. P. Balancing fish consumption benefits with mercury exposure. Science. 278:1997;1904-1905.
38. Elhassani S., Amin-Zaki L., Majeed M. A., Clarkson T. W., Doherty R. A., Greenwood M. R., Kilpper R. W. Exchange transfusion treatment of methylmercury-poisoned children. J. Environ. Sci. Health. 13:1978;63-80.
39. Englender S. J., Atwood R. G., Landrigan P. J., Clarkson T. W., Greenwood M. R., Smith J. C. Organic mercury exposure from fungicide contaminated eggs. Arch. Environ. Health. 35:1980;224-228.
40. Fagan D. G., Prichard J. S., Clarkson T. W., Greenwood M. R. Organ mercury levels in infants with omphaloceles treated with organic mercurial antiseptic. Arch. Dis. Child. 52:1977;962-964.
41. Gotelli C. A., Astolfi E., Cox C., Cernichiari E., Clarkson T. W. Early biochemical effects of an organic mercury fungicide on infants: "Dose makes the poison." Science. 22:1985;638-640.
42. Grandjean P., Weihe P., Jorgensen P. J., Clarkson T., Cernichiari E., Videro T. Impact of maternal seafood diet on fetal exposure to mercury, selenium, and lead. Arch. Environ. Health. 47:1992;185-195.
43. Grandjean P., Weihe P., White R. F. Milestone development in infants exposed to methylmercury from human milk. Neurotoxicology. 16:1995;27-34.
44. Grandjean P., Weihe P., White R. F., Debes F., Araki S., Yokoyama K., Murata K., Sorensen N., Dahl R., Jorgensen P. J. Cognitive deficit in 7-year-old children with prenatal exposure to methylmercury. Neurotoxicol. Teratol. 19:1997;417-428.
45. Grandjean P., Weihe P., White R. F., Debes F. Cognitive performance of children prenatally exposed to "safe" levels of methylmercury. Environ. Res. 77:1998;165-172.
46. Greenwood M. R., Dhahir P., Clarkson T. W., Farrant J. P., Chartrand A., Khayat A. Epidemiological experiences with the Magos reagents in the determination of different forms of mercury in biological samples by flameless atomic absorption. J. Anal. Toxicol. 1:1977;265-269.
47. Greenwood M. R., Clarkson T. W., Doherty R. A., Gates A. H., Amin-Zaki L., Elhassani S., Majeed M. A. Blood clearance half-times in lactating and non-lactating members of a population exposed to methylmercury. Environ. Res. 16:1978;48-54.
48. Greenwood M. R. Methylmercury poisoning in Iraq. An epidemiological study of the 1971-1972 outbreak. J. Appl. Toxicol. 5:1985;148-159.
49. Gunderson V. M., Grant-Webster K. S., Burbacher T. M., Mottet N. K. Visual recognition memory deficits in methylmercury-exposed Macaca fasicularis infants. Neurotoxicol. Teratol. 10:1988;373-379.
50. Innis S. M. Essential fatty acids in growth and development. Progress Lipid Res. 30:1991;39-103.
51. Kershaw T. G., Clarkson T. W., Dhahir P. H. The relationship between blood levels and dose of methylmercury in man. Arch. Environ. Health. 35:1980;28-36.
52. Kjellstrom, T., Kennedy, P., Wallis, S., and Mantell, C.1986. Physical and mental development of children with prenatal exposure to mercury from fish. Stage 1. Preliminary tests at age 4. Solna, National Swedish Environmental Board. Report No. 3080, pp. 1-96.
53. Kromhout D., Bosschieter E. B., Coulander C. L. The inverse relation between fish consumption and 20-year mortality from coronary heart disease. N. Engl. J. Med. 312:1985;1205-1209.
54. Lapham L. W., Cernichiari E., Cox C., Myers G. J., Baggs R. B., Brewer R., Shamlaye C. F., Davidson P. W., Clarkson T. W. An analysis of autopsy brain tissue from infants prenatally exposed to methylmercury. Neurotoxicology. 16:1995;689-704.
55. Magos L., Tuffery A. A., Clarkson T. W. Volitalization of mercury by bacteria. Br. J. Ind. Med. 21:1964;294-298.
56. Magos L., Bakir F., Clarkson T. W., Al-Jawad A. M., Al-Soffi M. H. Tissue levels of mercury in autopsy specimens of liver and kidney. Bull. World Health Org. 53:1976;93-96.
57. Marsh D. O., Turner M., Smith J. C., Choi W. J., Clarkson T. W. Methyl mercury in human populations eating large quantities of marine fish. II. American Samoa: Cannery workers and fishermen. Proc. First International Mercury Conf., May 1974, Barcelona. II:1974;Fabrica National de Moneda y Timbre, Madrid. p. 235-239.
58. Marsh D. O., Myers G. J., Clarkson T. W., Amin-Zaki L., Tikriti S. Fetal methylmercury poisoning: New data on clinical and toxicological aspects. Trans. Am. Neurol. Assoc. 102:1977;1-3.
59. Marsh D. O., Myers G. J., Clarkson T. W., Amin-Zaki L., Tikriti S., Majeed M. A. Fetal methylmercury poisoning: Clinical and toxicological data on 29 cases. Ann. Neurol. 7:1980;348-353.
60. Marsh D. O., Myers G. J., Clarkson T. W., Amin-Zaki L., Tikriti S., Majeed M. A. Dose-response relationship for human fetal exposure to methylmercury. Clin. Toxicol. 18:1981;1311-1318.
61. Marsh D. O., Clarkson T. W., Cox C., Myers G. J., Amin-Zaki L., Al-Tikriti S. Fetal methylmercury poisoning. Arch. Neurol. 44:1987;1017-1022.
62. Marsh D. O. Organic mercury: Clinical and neurotoxicological aspects. deWolff F. A. Handbook of Clinical Neurology, Interactions of the Nervous System. 20:1994;413-429 Elsevier, Amsterdam.
63. Marsh D. O., Clarkson T. W., Myers G. J., Davidson P. W., Cox C., Cernichiari E., Tanner M. A., Lednar W., Shamlaye C. F., Choisy O., Hoareau C., Berlin M. The Seychelles study of fetal methylmercury exposure and child development: Introduction. Neurotoxicology. 16:1995a;583-596.
64. Marsh D. O., Turner M. D., Smith J. C., Allen P., Richadale N. Fetal methylmercury study in a Peruvian fish-eating population. Neurotoxicology. 16:1995b;717-726.
65. Matthews A. D. Mercury content of commercially important fish of the Seychelles, and hair mercury levels of a selected part of the population. Environ. Res. 30:1983;305-312.
66. Myers G. J., Marsh D. O., Cox C., Davidson P. W., Shamlaye C. F., Tanner M. A., Choi A., Cernichiari E., Choisy O., Clarkson T. W. A pilot neurodevelopment study of Seychellois children following in utero exposure to methylmercury from a maternal fish diet. Neurotoxicology. 16:1995a;629-638.
67. Myers G. J., Davidson P. W., Cox C., Shamlaye C. F., Tanner M. A., Choisy O., Sloane-Reeves J., Marsh D. O., Cernichiari E., Choi A., Berlin M., Clarkson T. W. Neurodevelopmental outcomes of Seychellois children sixty-six months after in utero exposure to methylmercury from a maternal fish diet: Pilot study. Neurotoxicology. 16:1995b;639-652.
68. Myers G. J., Marsh D. O., Davidson P. W., Cox C., Shamlaye C. F., Tanner M. A., Choi A., Cernichiari E., Choisy O., Clarkson T. W. Main neurodevelopmental study of Seychellois children following in utero exposure to methylmercury from a maternal fish diet: Outcome at six months. Neurotoxicology. 16:1995c;653-664.
69. Myers G. J., Davidson P. W., Cox C., Shamlaye C. F., Tanner M. A., Marsh D. O., Cernichiari E., Lapham L. W., Berlin M., Clarkson T. W. Summary of the Seychelles Child Development Study on the relationship of fetal methylmercury exposure to neurodevelopment. Neurotoxicology. 16:1995d;711-716.
70. Myers G. J., Davidson P. W., Shamlaye C. F., Axtell C. D., Cernichiari E., Choisy O., Choi A., Cox C., Clarkson T. W. Effects of prenatal methylmercury exposure from a high fish diet on developmental milestones in the Seychelles Child Development Study. Neurotoxicology. 18:1997a;819-830.
71. Myers G. J., Davidson P. W., Cox C., Shamlaye C. F., Choisy O., Cernichiari E., Choi A., Sloane-Reeves J., Axtell C., Gao P., Clarkson T. W. The Seychelles Child Development Study: Results and new directions through twenty-nine months. Water Air Soil Pollut. 97:1997b;53-61.
72. Nierenberg D. W., Nordgren R. E., Chang M. B., Siegler R. W., Blayney M. B., Hochberg F., Toribara T. Y., Cernichiari E., Clarkson T. W. Delayed cerebellar disease and death after accidental to dimethylmercury. N. Engl. J. Med. 338:1998;1672-1676.
73. Phelps R. W., Clarkson T. W., Kershaw T. G., Wheatley B. Interrelationships of blood and hair mercury concentrations in a North American population exposed to methylmercury. Arch. Environ. Health. 35:1980;161-168.
74. Rodier P. M., Aschner M., Sager P. R. Mitotic arrest in the developing CNS after prenatal exposure to methylmercury. Neurobehav. Toxicol. Teratol. 6:1984;379-385.
75. Rustam H., Hamdi T. Methyl mercury poisoning in Iraq. A neurologial study. Brain. 97:1974;500-510.
76. Rustam H., Von Burg R., Amin-Zaki L., Elhassani S. Evidence for a neuromuscular disorder in methylmercury poisoning: Clinical and electrophysiological findings in moderate to severe cases. Arch. Environ. Health. 30:1975;190-195.
77. Sager P. R., Aschner M., Rodier P. M. Persistent, differential alterations in developing cerebellar cortex of male and female mice after methylmercury exposure. Dev. Brain Res. 12:1984;1-11.
78. Shamlaye C. F., Marsh D. O., Myers G. J., Cox C., Davidson P. W., Choisy O., Cernichiari E., Choi A., Tanner M., Clarkson T. W. The Seychelles Child Development Study on neurodevelopmental outcomes in children following in utero exposure to methylmercury from a maternal fish diet: Background and demographics. Neurotoxicology. 16:1995;597-612.
79. Shephard D. A. E. Methyl mercury poisoning in Canada. Can. Med. Assoc. J. 114:1976;110-114.
80. Smith J. C., Farris F. F., Von Burg R. Chemical type of mercury in patients in the outbreak of organomercury poisoning in Iraq. Bull. WHO. 53:1976;61-64.
81. Nord. Hyg. Tidskr. 4:1971;19-364.
82. Turner M. D., Marsh D. O., Rubio C. E., Chiriboga J., Chiriboga C., Smith J. C., Clarkson T. W. Methylmercury in populations eating large quantities of marine fish. I. Northern Peru. Proc. First International Mercury Conf., May 1974, Barcelona. II:1974;Fabrica National de Moneda y Timbre, Madrid. p. 229-234.
83. Turner M. D., Marsh D. O., Smith J. C., Clarkson T. W., Inglis J. B., Rubino E. C., Chiriboga J., Chiriboga C. C. Methylmercury in populations eating large quantities of marine fish. Arch. Environ. Health. 35:1980;367-378.
84. Uauy-Dagach R., Valenzuela A. Marine oils: The health benefits of n-3 fatty acids. Nut. Rev. 54:1996;S102-S108.
85. Von Burg R., Rustam H. Conduction velocities in methylmercury poisoned patients. Bull. Environ. Contam. Toxicol. 12:1974a;81-85.
86. Von Burg R., Rustam H. Electrophysiological investigations of methylmercury intoxication in humans. Evaluation of peripheral nerve by conduction velocity and electromyography. Electroencephalogr. Clin. Neurophysiol. 37:1974b;381-392.
87. Wheatley B., Barbeau A., Clarkson T. W., Lapham L. Methylmercury poisoning in Canadian Indians - The elusive diagnosis. Can J. Neurol. Sci. 6:1979;417-422.
88. World Health Organization. 1990. Environmental Health Criteria 101 Methylmercury. Geneva, Switzerland, pp. 1-144.