Imprinting: Focusing on the center

Current Opinion in Genetics and Development

Volumn 10, Issue 5, 2000, Pages 550-554

  Ben Porath, Ittai ^a   Cedar, Howard ^a  

^a HEBREW UNIVERSITY OF JERUSALEM   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

ALLELE; GENE EXPRESSION; GENETIC ANALYSIS; GENOME IMPRINTING; HUMAN; MOLECULAR GENETICS; NONHUMAN; PRIORITY JOURNAL; REVIEW;

EID: 0033867606     PISSN: 0959437X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0959-437X(00)00126-X     Document Type: Review

References (46)

1. Imprinted expression of the Igf2r gene depends on an intronic CpG island
2. An enhancer deletion affects both H19 and Igf2 expression
3. Disruption of imprinting caused by deletion of the H19 gene region in mice
4. Epigenetic mechanisms underlying the imprinting of the mouse H19 gene
5. Deletion of the H19 differentially methylated domain results in loss of imprinted expression of H19 and Igf2
6. Imprinting in Prader-Willi and Angelman syndromes
7. Towards a molecular understanding of Prader-Willi and Angelman syndromes
8. Imprinting-mutation mechanisms in Prader-Willi syndrome
9. Molecular mechanism of Angelman syndrome in two large families involves an imprinting mutation
10. A 5-kb ICdeletion in a family with Angelman syndrome reduces the shortest region of deletion overlap to 880 bp
11. Imprint switching on human chromosome 15 may involve alternative transcripts of the SNRPN gene
12. A mouse model for Prader-Willi syndrome imprinting-centre mutations
13. A transgene insertion creating a heritable chromosome deletion mouse model of Prader-Willi and Angelman syndromes
14. Paternal deletion from Snrpn to Ube3a in the mouse causes hypotonia, growth retardation and partial lethality and provides evidence for a gene contributing to Prader-Willi syndrome
15. Developmental pattern of gene-specific DNA methylation in the mouse embryo and germline
16. The ontogeny of allele-specific methylation associated with imprinted genes in the mouse
17. Structure of the imprinted mouse Snrpn gene and establishment of its parental-specific methylation pattern
18. Acquisition of the H19 methylation imprint occurs differentially on the parental alleles during spermatogenesis
19. Maternal-specific methylation of the imprinted mouse Igf2r locus identifies the expressed locus as carrying the imprinting signal
20. The imprinting box of the mouse Igf2r gene
21. DNA methylation in early development
22. Chromatin conformation of the H19 epigenetic mark
23. Characterization of novel parent-specific epigenetic modifications upstream of the imprinted mouse H19 gene
24. Parental allele-specific chromatin configuration in a boundary- imprinting-control element upstream of the mouse H19 gene
25. In vivo nuclease hypersensitivity studies reveal multiple sites of parental origin-dependent differential chromatin conformation in the 150 kb SNRPN transcription unit
26. Inactive allele-specific methylation and chromatin structure of the imprinted gene U2af1-rs1 on mouse chromosome 11
27. Parental chromosome-specific chromatin conformation in the imprinted U2af1-rs1 gene in the mouse
28. Embryonic inheritance of the chromatin organisation of the imprinted H19 domain in mouse spermatozoa
29. Transient inhibition of histone deacetylation alters the structural and functional imprint at fission yeast centromeres
30. Allele-specific replication timing of' imprinted gene regions
31. Allele specificity of DNA replication timing in the Angelman/Prader-Willi syndrome imprinted chromosomal region
32. Asynchronous replication of imprinted genes is established in the gametes and maintained during development
33. Tissue-specific and allele-specific replication timing control in the imprinted human Prader-Willi syndrome region
34. The mouse H19 locus mediates a transition between imprinted and non-imprinted DNA replication patterns
35. Gene structure, DNA methylation, and imprinted expression of the human SNRPN gene
36. De novo deletions of SNRPN exon 1 in early human and mouse embryos result in a paternal to maternal imprint switch
37. Loss of the maternal H19 gene induces changes in Igf2 methylation in both cis and trans
38. H19 and Igf2 monoallelic expression is regulated in two distinct ways
39. Imprinted expression of the murine Angelman syndrome gene, Ube3a, in hippocampal and Purkinje neurons
40. The Angelman syndrome candidate gene, UBE3A/E6-AP, is imprinted in brain
41. Imprinting of the Angelman syndrome gene, UBE3A, is restricted to brain
42. An imprinted antisense RNA overlaps UBE3A and a second maternally expressed transcript
43. The imprinted antisense RNA at the Igf2r locus overlaps but does not imprint Mas1
44. The protein CTCF is required for the enhancer blocking activity of vertebrate insulators
45. Methylation of a CTCF-dependent boundary controls imprinted expression of the Igf2 gene
46. CTCF mediates methylation-sensitive enhancer blocking activity at the H19/Igf2 locus