Ligand-presenting assembly: A method for C- and N-terminal antigen presentation

Journal of Peptide Research

Volumn 56, Issue 2, 2000, Pages 105-113

  Holm, Arne ^a   Jorgensen R M ^a   Ostergaard S ^b   Theisen, M ^c  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b NOVO NORDISK A S   (Denmark)

^c STATENS SERUM INSTITUT   (Denmark)

Author keywords

B cell epitope; Borrelia afzelii; Borrelia burgdorferi; Borrelia garinii; Dendritic; Ligand presenting assembly; LPA; Lyme borreliosis; MAP; SPPS; T cell epitope

Indexed keywords

DICARBOXYLIC ACID; EPITOPE;

AMINO TERMINAL SEQUENCE; ANTIGEN PRESENTATION; ARTICLE; BORRELIA AFZELII; BORRELIA BURGDORFERI; BORRELIA GARINII; CARBOXY TERMINAL SEQUENCE; CHIRALITY; LYME DISEASE; PEPTIDE SYNTHESIS; PRIORITY JOURNAL; PROTEIN ASSEMBLY;

AMINO ACID SEQUENCE; ANIMALS; ANTIGENS, BACTERIAL; BORRELIA; CARBON; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; ENZYME-LINKED IMMUNOSORBENT ASSAY; EPITOPES, B-LYMPHOCYTE; LIGANDS; MICE; MOLECULAR SEQUENCE DATA; NITROGEN;

BORRELIA; BORRELIA AFZELII; BORRELIA BURGDORFERI; BORRELIA GARINII;

EID: 0033863749     PISSN: 1397002X     EISSN: None     Source Type: Journal    
DOI: 10.1034/j.1399-3011.2000.00758.x     Document Type: Article

References (16)

1. 1. Tam, J.P. (1995) Synthesis and applications of branched peptides in immunological methods and vaccines. In Peptides: Synthesis, Structures, and Applications (Gutte, B., ed.). Academic Press, New York, pp. 455-500.
2. 2. Veprek, P. & Jezek, J. (1999) Peptide and glycopeptide dendrimers. Part I. J. Peptide Sci. 5, 5-23.
3. 3. Veprek, P. & Jezek, J. (1999) Peptide and glycopeptide dendrimers. Part II. J. Peptide Sci. 5, 203-220.
4. 4. Wells, N.J., Basso, A. & Bradley, M. (1998) Solid-phase dendrimer synthesis. Biopolymers Peptide Sci. 47, 381-396.
5. 5. Tam, J.P. (1996) Recent advances in multiple antigen peptides. J. Immunol. Methods 196, 17-32.
6. 6. Heegaard, P.M.H., Bøg, Y.S., Jakobsen, P.H. & Holm, A. (1998) A stem peptide carrier for the immunogenic presentation of peptides. In Solid Phase Synthesis and Combinatorial Chemical Libraries (Epton, R., ed.). Mayflower Scientific Ltd, Birmingham, UK, pp. 143-146.
7. 7. Tam, J.P. (1988) Synthetic peptide vaccine design: synthesis and properties of a high-density multiple antigenic peptide system. Proc. Natl Acad. Sci. USA 85, 5409-5413.
8. 8. Aletras, A., Barlos, K., Gatos, D., Koutsogianni, S. & Mamos, P. (1995) Preparation of the very acid-sensitive Fmoc-Lys(Mtt)-OH. Application in the synthesis of side-chain to side-chain cyclic peptides and oligolysine cores suitable for the solid-phase assembly of MAPs and TASPs. J. Peptide Protein Res. 45, 488-496.
9. 9. Keah, H.H., Kecorius, E. & Hearn, M.T.W. (1998) Direct synthesis and characterization of multi-dendritic peptides for use as immunogens. J. Peptide Res. 51, 2-8.
10. 10. Mathiesen, M.J., Holm, A., Christiansen, M., Blom, J., Hansen, K., Østergaard, S. & Theisen, M. (1998) The dominant epitope of Borrelia garinii outer surface protein C recognized by sera from patients with neuroborreliosis has a surface-exposed conserved structural motif. Infect. Immun. 66, 4073-4079.
11. 11. Kim, H.O., Ji, X.-D., Melman, N., Olah, M.E., Stiles, G.L. & Jacobson, K.A. (1994) Structure-activity-relationships of 1,3-dialkylxanthine derivatives at rat A(3) adenosine receptors. J. Med. Chem. 37, 3373-3382.
12. 12. Brandt, L., Oettinger, T., Holm, A., Andersen, A.B. & Andersen, P. (1996) Key epitopes on the ESAT-6 antigen recognized in mice during the recall of protective immunity to mycobacterium tuberculosis. J. Immunol. 157, 3527-3533.
13. 13. Mathiesen, M.J., Christiansen, M., Hansen, K., Holm, A., Åsbrink, E. & Theisen, M. (1998) Peptide-based OspC enzyme-linked immunosorbent assay for serodiagnosis of lyme borreliosis. J. Clin. Microbiol. 36, 3474-3479.
14. 14. Undheim, K. & Kremminger, P. (1993) Double chain peptide compounds having hemoregulatory activity. WO 93/24523.
15. 15. Lange, M., Cuthbertson, A.S., Towart, R. & Fischer, P.M. (1998) Synthesis and activity of dimeric bradykinin antagonists containing diaminodicarboxylic acid bridge residues. J. Peptide Sci. 4, 289-293.
16. 16. Bhatnagar, P.K., Agner, E.K., Alberts, D., Arbo, B.E., Callahan, J.F., Cuthbertson, A.S., Engelsen, S.J., Fjerdingstad, H., Hartmann, M., Heerding, D., Hiebl, J., Huffman, W.F., Hysben, M., King, A.G., Kremminger, P., Kwon, C., LoCastro, S., Løvhaug, D., Pelus, L.M., Petteway, S. & Takata, J.S. (1996) Structure-activity relationships of novel hematoregulatory peptides. J. Med. Chem. 39, 3814-3819.