Regulation of the expression of human ferrochelatase by intracellular iron levels

European Journal of Biochemistry

Volumn 267, Issue 15, 2000, Pages 4685-4692

  Taketani, Shigeru ^a   Adachi, Yasushi ^b   Nakahashi, Yoshitsugu ^b  

^a KYOTO INSTITUTE OF TECHNOLOGY   (Japan)

^b KANSAI MEDICAL UNIVERSITY   (Japan)

Author keywords

Desferfioxamine; Ferrochelatase; Iron; Iron sulfur cluster; K562 cells

Indexed keywords

DEFEROXAMINE; FERROCHELATASE; HEME; MESSENGER RNA; NITRILOTRIACETATE IRON;

ANIMAL CELL; ARTICLE; CELL STRAIN K 562; HEME SYNTHESIS; HUMAN; HUMAN CELL; MITOCHONDRION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ANIMALS; CHELATING AGENTS; COPROPORPHYRINOGEN OXIDASE; COS CELLS; CYTOPLASM; DEFEROXAMINE; DOSE-RESPONSE RELATIONSHIP, DRUG; ESCHERICHIA COLI; FERRIC COMPOUNDS; FERROCHELATASE; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HEME; HUMANS; IMMUNOBLOTTING; IRON; K562 CELLS; MITOCHONDRIA; MUTAGENS; NITRILOTRIACETIC ACID; PLASMIDS; RNA, MESSENGER; TIME FACTORS;

EID: 0033862936     PISSN: 00142956     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1432-1327.2000.01519.x     Document Type: Article

References (32)

1. The structural organization of haem synthesis of rat liver mitochondria
2. Molecular and genetic characterization of ferrochelatase
3. Ferrochelatase
4. Site-directed mutagenesis of human ferrochelatase. Identification of histidine-263 as a binding site for metal ions
5. Probing the active site residues in Saccharomyces cerevisiae ferrochelatase by site directed mutagenesis
6. Mammalian ferrochelatase. A new addition to metalloenzyme
7. Nitric oxide-mediated inactivation of mammalian ferrochelatase in vivo and in vitro. Possible involvement of the iron-sulphur cluster of the enzyme
8. Human ferrochelatase is an iron-sulfur protein
9. Iron-sulfur clusters as biosensors of oxidants and iron
10. Loss and degradation of enzyme-bound heme induced by cellular nitric oxide synthesis
11. Function of the [2Fe-2S] cluster in mammalian ferrochelatase. A possible role as a nitric oxide sensor
12. The mitochondrial protein Atmlp and Nfs lp are essential for biogenesis of cytosolic Fe/S proteins
13. Mechanism of iron transport to the site of heme synthesis inside yeast mltochondria
14. Induction of terminal enzyme for heme biosynthesis during differentiation of mouse erythro-leukemia cells
15. Molecular cloning and sequence analysis of cDNA encoding human ferrochelatase
16. Molecular cloning, sequencing and expression of cDNA encoding human coproporphyrinogen oxidase
17. The effects of lead on differentiation of the Friend leukemia cells and rat bone marrow cells
18. Molecular cloning, sequencing and expression of mouse ferrochelatase
19. Overexpression in Escherichia coli, and one-step purification of the human recombinant ferrochelatase
20. Overexpression, purification, and characterization of ferrochelatase from Escherichia coli
21. A rapid and sensitive method for quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
22. A molecular defect in human protoporphyrria
23. Prediction and identification of new neutral substrate of the yeast mitochondrial intermediate peptidase
24. Mitochondrial intermediate peptidase and the yeast frataxin homolog together maintain mitochondrial iron homeostasis in Saccharomyces cerevisiae
25. M1P1, a new yeast gene homologous to rat mitochondrial intermediate peptidase, is required for oxidative metabolism in Saccharomyces cerevisiae
26. Effect of decreased ferrochelatase activity on iron and porphyrin content in mitochondria of mice with porphyria induced by gdse0fuivin
27. Aconitase and mitochondrial iron-sulfur protein deficiency in Friedrich ataxia
28. Mt-Hsp70 homolog, Ssc2p, required for maturation of yeast frataxin and mitochondrial iron homeostasis
29. Molecular mechanisms of the metabolism and transport of iron in normal and neoplastic cells
30. Regulation of genes of iron metabolism by iron-response proteins
31. Translational regulation via iron-responsive elements by the nitric oxide/NO synthase pathway
32. Nitric oxide and mitochondrial respiration