The effect of prolil-glycil-proline (PGP) peptide and PGP-rich substances on haemostatic parameters of rat blood

Blood Coagulation and Fibrinolysis

Volumn 11, Issue 5, 2000, Pages 409-414

  Lyapina, L A ^a   Pastorova, V E ^a   Samonina, G E ^a   Ashmarin, I P ^a  

^a MOSCOW STATE UNIVERSITY   (Russian Federation)

Author keywords

Anticoagulant activity; Factor XIIIa; Fibrinolysis; Haemostasis; PGP rich substances; Platelet aggregation; Prolil glycil proline (PGP); Thrombosis; Tissue plasminogen activator

Indexed keywords

ANTIPLASMIN; BLOOD CLOTTING FACTOR 13A; FIBRIN; FIBRINOGEN; GELATIN; PROLYL GLYCIL PROLINE PEPTIDE; TISSUE PLASMINOGEN ACTIVATOR; TRIPEPTIDE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTICOAGULATION; ARTICLE; CONTROLLED STUDY; DEPOLYMERIZATION; DOSE RESPONSE; FIBRINOLYSIS; HEMOSTASIS; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; THROMBOCYTE AGGREGATION; THROMBOGENESIS;

ADMINISTRATION, INTRANASAL; ANIMALS; ANTICOAGULANTS; ANTIFIBRINOLYTIC AGENTS; DIET; FIBRIN; FIBRINOGEN; FIBRINOLYTIC AGENTS; GELATIN; HEMOSTASIS; INJECTIONS, INTRAVENOUS; MALE; OLIGOPEPTIDES; PROLINE; RATS; RATS, WISTAR; TISSUE PLASMINOGEN ACTIVATOR; TRANSGLUTAMINASES;

EID: 0033861119     PISSN: 09575235     EISSN: None     Source Type: Journal    
DOI: 10.1097/00001721-200007000-00002     Document Type: Article

References (29)

1. 1. Xia T, Akers K, Eisen AZ, Seitzer JL. Comparison of cleavage site specificity of gelatinases A ana B using collagenous peptides. Biochim Biophys Acta 1996; 1293: 259-266.
2. 2. Harrington R. Design and methodology of the pursuit trial, evaluting eptifibatide for acute ischemic coronary syndromes. Platelet glycoprotein IIIb/IIa in unstable angina: receptor suppression using integrin therapy. Am J Cardiol 1997; 80: 34B-37B.
3. 1 in the procoagulant response of single, collagen-adherent platelets. Thromb Haemost 1999; 81: 782-792.
4. 4. Asselin J, Knight CG, Farndale RW, Barnes MJ, Watson SP. Monomeric (glycine-proline-hydroxyproline) 10 repeat sequence is a partial agonist of the platelet collagen receptor glycoprotein YI. Biochem J 1999; 339: 413-418.
5. 1 side chains as highly selective inhibitors of thrombin. J Mol Chem 1995; 38: 9-15.
6. 6. Lewis SD, Ng AS, Lyle EA, Mellott MJ. Inhibition of thrombin by peptides containing lysil-alpha-keto carbonyl derivates. Thromb Haemost 1995; 74: 1107-1112.
7. 7. Vlasuk GP. Structural and functional characterization of tick anticoagulant peptide (TAP): a potent and selective inhibitor of blood coagulation factor Xa. Thrombos Haemostas 1993; 70: 212-218
8. 8. Ashmarin IP, Pastorova VE, Lyapina LA, Kudrjashov BA, Kalihevich VN, Kamenskii AA, et al. Effect of tuftsine on fibrin polymerization in vitro and haemostasis system at intravenous injection into healthy animals. Izvestij AS (Russia) Ser Biol 1991; 2: 302-306.
9. 9. Neises B, Broersma RJ, Tarnus C, et al. Synthesis and comparison of tripeptidylfluoroalkane thrombin inhibitors. Bioorg Med Chem 1995; 23: 1049-1061.
10. 10. Ramesh CV, Jayakumar R, Puvanakrishnan R. In vitro studies on a novel micelleforming peptide with anticoagulant activity. Int J Peptid Protein Res 1995; 45: 386-390.
11. 11. Chen XC, Hua ZC, Zhu DX. A low molecular weight urokinase derivative with enhanced fibrin affinity. Biochem Mol Biol Int 1996; 239: 797-803.
12. 12. Topol EJ, Plow EF. Clinical trials of platelet receptor inhibitors. Thromb Haemost 1993; 70: 94-98.
13. 13. Ashmarin IP, Lyapina LA, Pastorova VE. Modulation of in vitro and in vivo haemostatic reactions by representatives of regulatory peptides families. Vestnik RAMS (Russia) 1996; 6: 50-58.
14. 14. Ashmarin IP, Karaseeva EP, Lyapina LA, Samonina GE. The simplest proline containing peptides PG, GP, PGP and GPGG as putative bioregulators and possible sources of their synthesis. Biochemistry (Moscow, Russia) 1998; 63: 149-155.
15. 15. Mei J, Erlanson-Albertsson C. Effect of enterostatin given intravenously and intra-cerebroventricularly on high-fat feeding in rats. Regul Pept 1992; 41: 209-218.
16. 16. Lin L, McKlanahan S, York DA, Bray GA. The peptide enterostatin may produce early satiety. Physiol Behav 1993; 53:789-794.
17. 17. Wessler S, Reiner SM, Sheps MC. Biologic assay of a thrombosis inducing ability in human serum. J Appl Physiol 1959; 14: 943-946.
18. 18. Biggs R. Human blood coagulation and its disorders. Oxford: Blackwell Scientific; 1976.
19. 19. Dolgov VV, Avdeeva NA, Chetnikovich KA. The methods of haemostatic study. Moscow, Russia: Ministry of Public Health; 1996. pp. 9-12.
20. 20. Kudrjashov BA, Lyapina LA, Baskova IP. The modernisation of the method for the determination of nonenzymatic fibrinolytic activity of plasma and some of its fractions. Vestnik Moscow Univ Ser Biol 1974; 5: 41-44.
21. 21. Astrup T, Kok P. Assay and preparation of a tissue plasminogen activator. Methods Enzymol 1970; 19: 821-834.
22. 22. Teger-Nilsson AC, Friberger P, Gyzander E. Determination of a new rapid plasmin inhibitor in human blood by means of a plasmin specific tripeptide substrate. Scand J Clin Lab Invest 1977; 37: 403-406.
23. 23. Born GVR. Aggregation of blood platelet by adenosindiphosphate and its reversal. Nature 1962; 194: 927-929.
24. 24. Spaethe R. In: Schulte B, Garrett J (editors): Haemostasis, physioligy, pathophysiology, diagnostics. VI. Methods of analyzing haemostasis. Munchen: ASH/ Deutschland GmbH; 1985. p. 135.
25. 25. Bidwell E. Fibrinolysis of human plasma. Biochem J 1953; 155: 407-506.
26. 26. Regers J, Mussoni L, Donati MB, Dc Gaetano G. Failure of aspirin at different doses to modify experimental thrombosis in rats. Thromb Res 1980; 18: 669-674.
27. 27. van Ryn-Mc Kenna J, Ofosu FA, Gray E, Hirsh E, Buchanan MR. Effect of dermatan sulphate and heparin on inhibition of thrombus growth in vivo. Ann N Y Acad Sci 1989; 556: 304-312.
28. 28. Gardner ML, Illingworth KM, Kelleher G, Wood D. Intestinal absorption of the intact peptide carnosine in man and comparison with permeability to lactulose. J Physiol 1991; 431: 411-422
29. 29. Ganapathy V, Mendicino JF, Leibach FH. Transport of glycyl-L-proline into intestinal and renal brush border vesicles from rabbit. J Biol Chem 1981; 256: 118-124.