Menadione-induced oxidative stress inhibits cholecystokinin-stimulated secretion of pancreatic acini by cell dehydration

Pancreas

Volumn 21, Issue 2, 2000, Pages 191-202

  Han, Bing ^a   Klonowski Stumpe, Hanne ^a   Lüthen, Reinhard ^a   Schreiber, Rainer ^a   Häussinger, Dieter ^a   Niederau, Claus ^b  

^a HEINRICH HEINE UNIVERSITY   (Germany)

^b UNIVERSITY HOSPITAL ESSEN   (Germany)

Author keywords

Enzyme secretion; Free radicals; Glutathione; Hydration; Pancreas; Pancreatitis

Indexed keywords

CALCIUM; CHOLECYSTOKININ; FREE RADICAL; MENADIONE;

ACINAR CELL; ANIMAL CELL; ARTICLE; CALCIUM CELL LEVEL; CELL FUNCTION; CELL STRUCTURE; CONTROLLED STUDY; DEHYDRATION; ENZYME RELEASE; HORMONE BINDING; LIPID PEROXIDATION; NONHUMAN; OXIDATION; OXIDATIVE STRESS; PANCREAS SECRETION; PANCREATITIS; PRIORITY JOURNAL; RAT;

ADENOSINE TRIPHOSPHATE; AMYLASES; ANIMALS; BODY WATER; CALCIUM; CARBACHOL; CELL NUCLEUS; CELL SIZE; CHOLECYSTOKININ; ENDOPLASMIC RETICULUM; FREE RADICALS; GLUTATHIONE; INOSITOL 1,4,5-TRISPHOSPHATE; LIPID PEROXIDATION; MITOCHONDRIA; OXIDATION-REDUCTION; OXIDATIVE STRESS; PANCREAS; RATS; RECEPTORS, CHOLECYSTOKININ; VACUOLES; VITAMIN K;

EID: 0033859643     PISSN: 08853177     EISSN: None     Source Type: Journal    
DOI: 10.1097/00006676-200008000-00013     Document Type: Article

References (41)

1. Oxidative damage to the pancreas: Mechanisms and clinical implications
2. Oxidative and proteolytic cell injury: Comparison of susceptibility of isolated rat pancreatic acinar cells versus isolated rat hepatocytes
3. The metabolism of menadione (2-methyl-1,4-naphthoquinone) by isolated hepatocytes
4. Toxic effects and detection of oxygen free radicals on cultured articular chondrocytes generated by menadione
5. Xanthine oxidase-induced injury to endothelium: Role of intracellular iron and hydroxyl radical
6. 2+-homeostasis on hepatocyte canalicular function in vitro
7. 2+ homeostasis
8. Inhibition of biliary taurocholate excretion during menadione metabolism in perfused rat liver
9. 2+ concentration and cytotoxicity in hepatocytes exposed to oxidative stress
10. Menadione-induced bleb formation in hepatocytes is associated with the oxidation of thiols groups in actin
11. Pancreatic exocrine secretion in acute experimental pancreatitis
12. Beneficial effects of L-2-oxothiazolidine-4-carboxylate on caerulein pancreatitis in mice
13. Effect of ions on amylase release by dissociated pancreatic acinar cells
14. Intracellular vacuoles in experimental acute pancreatitis in rats and mice are an acidified compartment
15. Action of secretagogues on a new preparation of functionally intact, isolated pancreatic acini
16. Release of reactive oxygen by hepatocytes on reoxygenation: Three phases and role of mitochondria
17. Formation of thiobarbituric acid-reactive substance from deoxyribose in the presence of iron salts - The role of superoxide and hydroxyl radicals
18. The deoxyribose method: A simple 'test-tube' assay for determination of rate constants for hydroxyl radicals
19. Intrapancreatic zymogen activation and levels of ATP and glutathione during cerulein pancreatitis in rat
20. Enzymatic method for quantitative determination of nanogram amounts of total and oxidized glutathione: Applications to mammal blood and other tissues
21. Binding of cholecystokinin to high affinity receptors on isolated rat pancreatic acini
22. Characterization of the swelling-induced alkalinization of endocytotic vesicles in fluorescent isothiocycanate-dextran-loaded hepatocytes
23. The effect of oxidative stress on cellular functions and cytosolic calcium of rat pancreatic acinar cells
24. 3 production and amylase release in pancreatic acini
25. Cell volume changes modulate CCK- and carbachol-stimulated amylase release in isolated rat pancreatic acini
26. Menadione exerts both apoptosis and necrosis in rat pancreatic acinar AR4-2J cells
27. Depletion of pancreatic glutathione results in the inhibition of secretagogue-stimulated amylase secretion but does not prevent secretagogue-induced rise in intracellular calcium in rat acini
28. The effect of L-buthionine-[S,R]-sulfoximine on the pancreas in mice: A model of weakening the glutathione-based defense mechanisms
29. 2+ in individual pancreatic acini
30. Cytosolic calcium oscillators
31. Oscillatory mode of calcium signaling in rat pancreatic acinar cells
32. 2+ spikes in mouse pancreatic acinar cells
33. The role of cellular hydration in the regulation of cell function
34. + balance in perfused rat liver
35. H2Os induced hyperosmolarity of pancreatic B-cells
36. Regulation of tauro-cholate excretion by a hypo-osmolarity-activated signal transduction pathway in rat liver
37. Regulation of vesicular pH in liver macrophages and parenchymal cells by ammonia and anisotonocity as assessed by fluorescein isothiocyanate-dextran fluorescence
38. Involvement of microtubules in the link between cell volume and pH of acidic cellular compartments in rat and human hepatocates
39. Rat pancreatic zymogen granules: An actively acidified compartment
40. Cellular hydration state: An important determinant of protein catabolism in health and disease
41. Therapeutic regiments in acute experimental hemorrhagic pancreatitis. Effects of hydration, oxygenation, peritoneal lavage, and a potent protease inhibitor