Neuroborreliosis in Bulgaria: Detection of Borrelia burgdorferi-specific intrathecal antibody production

International Journal of Immunopathology and Pharmacology

Volumn 13, Issue 2, 2000, Pages 99-106

  Christova, I ^a   Tasseva, E ^b   Stamenov, B ^b   Sabev, K ^b  

^a NATIONAL CENTER OF INFECTIOUS AND PARASITIC DISEASES   (Bulgaria)

^b NONE

Author keywords

B. burgdorferi; Lyme borreliosis; Neuroborreliosis

Indexed keywords

ANTIBODY; CEFTRIAXONE; IMMUNOGLOBULIN G ANTIBODY; IMMUNOGLOBULIN M ANTIBODY; PENICILLIN G;

ADULT; AGED; ANTIBODY PRODUCTION; ARTICLE; BORRELIA; BORRELIA BURGDORFERI; BRAIN INFECTION; BULGARIA; CEREBROSPINAL FLUID; CRANIAL NEUROPATHY; FEMALE; HUMAN; LYME DISEASE; MAJOR CLINICAL STUDY; MALE; MENINGOENCEPHALITIS; MOTOR NEURON DISEASE; MULTIPLE SCLEROSIS; PRIORITY JOURNAL; RADICULITIS; SEROLOGY;

EID: 0033858331     PISSN: 03946320     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (29)

1. Reiber H. and P. Lange. 1991. Quantification of virus specific antibodies in CSF and serum : sensitive and specific detection of antibody synthesis in brain. Clin. Chem. 37:1153.
2. S. Frydas, M. Reale, R.C. Barbacane, P. Conti, F.C. Placido, I. Cataldo, D. Dimitriodou, A. Trakatellis and G. Anogianakis. 1997. Generation of monocyte chemotactic protein-1 (MCP-1) and TNF-α in mouse serum from trichinellosis. Int. J. Immunopathol. Pharmacol. 10:23.
3. S. Frydas, T. Rallis, I. Theodorides, M.N. Patsikas, C. Trakatellis, M. Di Gioacchino and M. Felaco. 2000. Trichinella spiralis infection is mediated by MCP-1 and MIP-2, while Echinococcus granulosus is mediated strongly by MCP-1, but not MIP-2. Int. J. Immunopathol. Pharmacol. 13:21.
4. Reiber H. and K. Felgenhauer. 1987. Protein transfer at the blood-cerebrospinal fluid barrier and the quantification of the humoral immune response within the central nervous system. Clin. Chim. Acta 163:319.
5. Reiber H. 1994. Flow rate of cerebrospinal fluid (CSF) -a concept common to normal blood-CSF barrier function and to dysfunction in neurological diseases. J. Neurol. Sci. 122:189.
6. Georgieva G., Ch. Manev, R. Savova and I. Christova. 1995. Ixodic ticks from Sofia and surroundings infected with borreliae. Infectologia (Bulgarian) 33:44.
7. Georgieva G., A. Kostova, I. Christova, M. Deneva and Ch. Manev. 1995. Ixodic ticks (Acarina, Ixodidae) infected with borreliae and epidemiological investigations on Lyme borreliosis in Varna region. Infectologia (Bulgarian) 32:36.
8. Christova I., S. Hohenberger, C. Zehetmeier and B. Wilske. 1998. First characterization of Borrelia burgdorferi sensu lato from ticks and skin biopsy in Bulgaria. Med. Microbiol. Immunol. 186:171.
9. Dourmishev L. and I. Christova. Erythema migrans : Isolation of Borrelia from skin lesions and serological diagnosis. 1997. Austral. J. Dermatol., 38: 7.
10. Christova I. and J.S. Dumler. 1999. Human granulocytic ehrlichiosis in Bulgaria. Am. J. Trop. Med. Hyg. 60:58.
11. Stoilov R., B. Stamenov, V. Zarcheva, I. Christova, Ch. Manev and K. Noeva. 1995. Clinical manifestations of Lyme borreliosis in Bulgarian population. Reumatologia (in Bulgarian) 2:26.
12. Murray N., W. Kristoferitsch, G. Stanek and A. J. Steck. 1986. Specificity of CNS antibodies against components of Borrelia burgdorferi in patients with meningopolyneuritis Garin-Bujadoux-Bannwarth. J. Neurol. 233:224.
13. Martin R., U. Martens, V. Sticht-Groh, R. Dörries and H. Krüger. 1988. Persistent intrathecal secretion of oligoclonal Borrelia burgdorferi-specific IgG in chronic meningoradiculomyelitis. J. Neurol. 235:229.
14. Hansen K., C. Mabel and H. Link. 1990. Oligoclonal Borrelia burgdorferi-specific IgG antibodies in cerebrospinal fluid in Lyme neuroborreliosis. J. Infect. Dis. 161:1194.
15. Stiernstedt G.T., M. Granström, B. Hederstedt and B. Sköldenberg. 1985. Diagnosis of spirochetal meningitis by enzyme-linked immunosorbent assay and indirect immunofluorescence assay in serum and cerebrospinal fluid. J. Clin. Microbiol. 21:819.
16. Wilske B., G. Schierz, V. Preac-Mursic, K. von Busch, R. Kühbeck, H.W. Pfister and K. Einhäupl. 1986. Intrathecal production of specific antibodies against Borrelia burgdorferi in patients with lymphocytic meningoradiculitis (Bannwarthís syndrome). J. Infect.Dis. 153:304.
17. Hansen K., P. Hindersson and N.S. Pedersen. 1988. Measurement of antibodies to the Borrelia burgdorferi flagellum improves serodiagnosis in Lyme disease. J. Clin. Microbiol. 26:338.
18. Hammers-Berggren S., K. Hansen, A.-M. Lebech and M. Karlsson. 1993. Borrelia burgdorferi-specific intrathecal antibody production in neuroborreliosis : a follow-up study. Neurol.43:169.
19. Felgenhauer K. and H.-J. Scha‰dlich. 1987. The compartmental IgM and IgA response within the central nervous system. J. Neurol. Sci. 77:125.
20. Kaiser R. 1994. Variable CSF findings in early and late Lyme neuroborreliosis : a follow-up study in 47 patients. J. Neurol. 242:26.
21. Hansen K. and A.-M. Lebech. 1991. Lyme neuroborreliosis : a new sensitive diagnostic assay for intrathecal synthesis of Borrelia burgdorferi-specific immunoglobulin G, A, and M. Ann. Neurol. 30:197.
22. Henriksson A., H. Link, M. Cruz and G. Stiernstedt. 1986. Immunoglobulin abnormalities in cerebrospinal fluid and blood overthe course of lymphocytic meningoradiculitis (Bannwarth's syndrome). Ann. Neurol. 20:337.
23. Yang L., Y. Ma, R. Schoefeld, M. Griffiths, E. Eichwald, B. Araneo and J.J. Weis. 1992. Evidence for B-lymphocyte mitogen activity in Borrelia burgdorferi-infected mice. Infect. Immunol. 60:3033.
24. Halperin, J.J., B.J. Luft, A.K. Anand, C.T. Roque, D. Alvarez, D.J. Volkman and R.J. Dattwyler. 1989. Lyme neuroborreliosis : central nervous system manifestations. Neurol. 39:753.
25. C. Zagaglia, I. Sollini, D. Paludi, F. Modica, R. Piccolomini, G. Catamo, A. Calconi, E. Filetici, M. Casalino and M. Nicoletti. 1999. Virulence factors of Salmonella ser. Enteritidis strains isolated in Italy from food-borne outbreaks. Int. J. Immunopathol. Pharmacol. 12:89
26. 3 mice. Int. J. Immunopathol. Pharmacol. 10:167.
27. Camponovo F. and C. Meier. 1986. Neuropathy of vasculitis origin in a case of Garin-Bujadoux-Bannwarth syndrome with positive borrelia antibody response. J. Neurol. 233: 69.
28. Vallat J.M., J. Hugon, M. Lubean, M.J. Leboutet, M. Dumas and R. Desproges-Gotteron. 1987. Tick-bite meningoradiculoneuritis. Neurol. 37:749.
29. Coyle P.K., L.B. Krupp and C. Doscher. 1993. Significance of reactive Lyme serology in multiple sclerosis. Ann. Neurol. 34:745.