3 Methylcholanthrene triggers the differentiation of alveolar tumor cells from canine bronchial basal cells and an altered p53 gene promotes their clonal expansion

Carcinogenesis

Volumn 21, Issue 8, 2000, Pages 1477-1484

  Ten Have Opbroek, Ank A W ^a   Shi, Xu Bao ^b   Gumerlock, Paul H ^b  

^a LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3 METHYLCHOLANTHRENE; CYCLINE; PROTEIN P53; SURFACTANT PROTEIN A;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIGEN EXPRESSION; ARTICLE; BASAL CELL; BRONCHUS MUCOSA; CANCER GRADING; CANCER GROWTH; CELL DIFFERENTIATION; CONTROLLED STUDY; DOG; DYSPLASIA; GENE EXPRESSION REGULATION; GENETIC SCREENING; GROWTH REGULATION; HISTOPATHOLOGY; HYPERPLASIA; IMMUNOHISTOCHEMISTRY; LUNG ALVEOLUS CELL TYPE 2; LUNG CARCINOGENESIS; LUNG CARCINOMA; MISSENSE MUTATION; MOUSE; NONHUMAN; NUDE MOUSE; PHENOTYPE; PRIORITY JOURNAL; TUMOR SUPPRESSOR GENE;

EID: 0033857792     PISSN: 01433334     EISSN: None     Source Type: Journal    
DOI: 10.1093/carcin/21.5.477     Document Type: Article

References (40)

1. The p53 tumour suppressor gene
2. Thymocyte apoptosis induced by p53-dependent and independent pathways
3. Regulation of the cellular p53 tumor antigen in teratocarcinoma cells and their differentiated progeny
4. p53 and lung cancer
5. p53 mutations in human cancers
6. P53 mutant immunophenotype and deregulation of p53 transcription pathway (Bcl2, Bax and Waf1) in precursor bronchial lesions of lung cancer
7. Concurrent p53 expression in bronchial dysplasias and squamous cell lung carcinomas
8. p53 in squamous metaplasia: A marker for risk of respiratory tract carcinoma
9. Deletions of 17p and p53 mutations in preneoplastic lesions of the lung
10. Smoking attributable cancer mortality in 1991: Is lung cancer now the leading cause of death among smokers in the United States?
11. Persistent binding of 3-methylcholanthrene to mouse lung DNA and its correlation with susceptibility to pulmonary neoplasia
12. Relationships between carcinogen metabolism adduct binding and DNA damage in 3-methylcholathreneexposed lung
13. Cocarcinogenic effect of cytochrome P-450 1A1 inducers for epidermoid lung tumour induction in rats previously exposed to radon
14. Bronchial and pulmonary carcinogenesis at focal sites in dogs and hamsters
15. Carcinogenesis in heterotopic respiratory epithelium in canine subcutaneous bronchial autografts
16. Non-small cell lung cancer in autogenous subcutaneous bronchial grafts in dogs
17. Expression of alveolar type II cell markers in acinar adenocarcinomas and adenoid-cystic carcinomas arising from segmental bronchi. A study in a heterotopic bronchogenic carcinoma model in dogs
18. Invited review: In favour of an oncofoetal concept of bronchogenic carcinoma development
19. Alveolar stem cells in canine bronchial carcinogenesis
20. Bronchiolo-alveolar regions in adenocarcinoma arising from canine segmental bronchus
21. Morphogenetic and, functional activity of type II cells in early fetal Rhesus monkey lungs. A comparison between primates and rodents
22. The proximal border of the human respiratory unit, as shown by scanning and transmission electron microscopy and light microscopical cytochemistry
23. Metastatic behaviour of canine lung carcinoma in autochthonous and xenotransplant hosts
24. International histological classification of tumours of domestic animals. I. Tumors of the lung
25. The World Health Organization Histologic typing of lung tumours. 2nd edn
26. Detection of the type II cell or its precursor before week 20 of human gestation, using antibodies against surfactant-associated proteins
27. Expression of the major surfactant-associated protein, SP-A, in type II cells of human lung before 20 weeks of gestation
28. Identification of p53 mutations in archival prostate tumors. Sensitivity of an optimized single-strand conformational polymorphism (SSCP) assay
29. Sequence analysis of canine p53 in the region of exons 3-8
30. The Cooperative Prostate Network: P53 abnormalities in primary prostate cancer: Single-strand conformation polymorphism analysis of complementary DNA in comparison with genomic DNA
31. Ultrastructural features of type II alveolar epithelial cells in early embryonic mouse lung
32. Ultrastructural characteristics of inclusion bodies of type II cells in late embryonic mouse lung
33. Mutation of the p53 tumor suppressor gene in spontaneously occurring osteosarcomas of the dog
34. Induction of alveolar type II cell differentiation in fetal tracheal epithelium by grafted distal lung mesenchyme
35. Induction of alveolar type II cell differentiation in embryonic tracheal epithelium in mesenchyme-free culture
36. The development of the lung in mammals: An analysis of concepts and findings
37. Lung development in the mouse embryo
38. The alveolar type II cell is a pluripotential stem cell in the genesis of human adenocarcinomas and squamous cell carcinomas
39. Expression of surfactant-associated protein in non-small-cell lung cancer: A discriminant between biologic subsets