Heparin-induced thrombocytopenia (HIT): In vitro and in vivo cross-reactivity to danaparoid sodium and successful treatment with recombinant hirudin (lepirudin)

European Journal of Haematology

Volumn 65, Issue 2, 2000, Pages 148-149

  Baumgärtel, Martin W ^a   Eichler, Petra ^b   Glöckner, Wolfgang M ^a   Ranze, Oliver ^b   Greinacher, Andreas ^b  

^a Department of Medicine   (Germany)

^b UNIVERSITY OF GREIFSWALD   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

DANAPAROID; HEPARIN; LEPIRUDIN;

ADULT; CASE REPORT; CROSS REACTION; DRUG EFFECT; FEMALE; HUMAN; LETTER; PRIORITY JOURNAL; THROMBOCYTE ACTIVATION; THROMBOCYTE COUNT; THROMBOCYTOPENIA;

ANTIBODIES; ANTICOAGULANTS; CHONDROITIN SULFATES; CROSS REACTIONS; DERMATAN SULFATE; DRUG COMBINATIONS; FEMALE; HEPARIN; HEPARITIN SULFATE; HIRUDIN THERAPY; HIRUDINS; HUMANS; MIDDLE AGED; RECOMBINANT PROTEINS; THROMBOCYTOPENIA;

EID: 0033857297     PISSN: 09024441     EISSN: None     Source Type: Journal    
DOI: 10.1034/j.1600-0609.2000.9L225.x     Document Type: Letter

References (8)

1. Antibodies from patients with heparin-induced thrombocytopenia/thrombosis are specific for platelet factor 4 complexed with heparin or bound to endothelial cells
2. Heparin-associated thrombocytopenia: Isolation of the antibody and characterization of a multimolecular PF4/heparin complex as the major antigen
3. Heparin-induced thrombocytopenia: Towards consensus
4. Sera from patients with heparin-induced thrombocytopenia generate platelet-derived microparticles with procoagulant activity: An explanation for the thrombotic complications of heparin-induced thrombocytopenia
5. Failure of Orgaran therapy in a patient with previous heparin-induced thrombocytopenia syndrome
6. A rapid and sensitive test for diagnosing heparin-associated thrombocytopenia
7. Laboratory diagnosis of heparin-associated thrombocytopenia and comparison of platelet aggregation test, heparin-induced platelet activation test, and platelet factor 4/heparin enzyme-linked immunosorbent assay
8. Fatal danaparoid sodium induced thrombocytopenia and arterial thromboses