Antitumor effects of soybean hypocotyls and soybeans on the mammary tumor induction by N-methyl-n-nitrosourea in F344 rats

Anticancer Research

Volumn 20, Issue 3 A, 2000, Pages 1439-1444

  Zaizen, Yukihiro ^a   Higuchi, Yasunori ^a   Matsuo, Noritaka ^a   Shirabe, Komei ^a   Tokuda, Harukuni ^b   Takeshita, Masazumi ^a  

^a OITA UNIVERSITY   (Japan)

^b KYOTO PREFECTURAL UNIVERSITY OF MEDICINE   (Japan)

Author keywords

Anti tumor promoting effect; Isoflavone; Mammary tumor; Soybean; Soybean hypocotyl

Indexed keywords

ANTINEOPLASTIC AGENT; ISOFLAVONE DERIVATIVE; METHYLNITROSOUREA; PLANT EXTRACT; SOYBEAN PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; BREAST TUMOR; CANCER INHIBITION; CANCER PREVENTION; CONTROLLED STUDY; FEMALE; NONHUMAN; PLANT GROWTH; PRIORITY JOURNAL; RAT;

ANIMALS; BODY WEIGHT; DIET; FEMALE; HYPOCOTYL; MAMMARY NEOPLASMS, EXPERIMENTAL; METHYLNITROSOUREA; PHYTOTHERAPY; RATS; RATS, INBRED F344; SOYBEANS;

EID: 0033856559     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (20)

1. Messina MJ, Persky V, Setchell KDR and Barnes S: Soy intake and cancer risk: A review of the in vitro and in vivo data. Nutr Cancer 21: 113-131, 1994.
2. Barnes S, Grubbs C, Setchell KDR and Carlson J: Soybeans inhibit mammary tumors in models of breast cancer. In: Mutagens and Carcinogens in the Diet (Pariza MW, Aeschbacher H-U, Felton JS and Sato S, eds). Wiley-Liss, New York, 239-253, 1990.
3. Kennedy AR: The evidence for soybean products as cancer preventive agents. J Nutr 125: 733S-743S, 1995.
4. Zhou J-R, Mukherjee P, Gugger ET, Tanaka T, Blackburn GL and Clinton SK: Inhibition of murine bladder tumorigenesis by soy isoflavones via alterations in the cell cycle, apoptosis, and angiogenesis. Cancer Res 58: 5231-5238, 1998.
5. Anderson RL and Wolf WJ: Compositional changes in trypsin inhibitors, phytic acid, saponins and isoflavones related to soybean processing. J Nutr 125: 581S-588S, 1995.
6. Zaizen Y, Tokuda H, Nishino H and Takeshita M: Inhlbitory effect of soybean hypocotyls on Epstein-Barr virus early antigen induction and skin tumor promotion. Cancer Lett 121: 53-57, 1997.
7. Constantinou AI, Mehta RG and Vaughan A: Inhibition of N-methyl-n-nitrosourea-induced mammary tumors in rats by the soybean isoflavones. Anticancer Res 16: 3293-3298, 1996.
8. Reeves PG, Melsen FH and Fahey GC Jr: AIN-93 purified diets for laboratory rodents: final report of the American institute of nutrition ad hoc writing committee on the reformulation of the AIN-76A rodent diet. J Nut 123: 1939-1951, 1993.
9. Takeshita M, Ueda H, Shirabe K, Higuchi Y and Yoshida S: Lack of promotion of colon carcinogenesis by high-oleic safflower oil. Cancer 79: 1487-1493, 1997.
10. Cohen LA, Chen-Backlund J-Y, Sepkovic DW and Sugie S: Effect of varying proportions of dietary menhaden and corn oil on experimental rat mammary tumor promotion. Lipids 28: 449-456, 1993.
11. Cohen LA, Thompson DO, Maeura Y, Choi K, Blank ME and Rose DP: Dietary fat and mammary cancer. I. Promoting effects of different dietary fats on N-nitrosomethylurea induced rat mammary tumorigenesis. J Natl Cancer Inst 77: 33-42, 1986.
12. Gullino PM, Pettigrew HM and Grantham FH: N-nitrosomethylurea as mammary gland carcinogen in rats. J Natl Cancer Ins 54: 401-409, 1975.
13. Herman C, Adlercreutz T, Goldin BR, Gorbach SL, Höckerstedt KAV, Watanabe S, Häämäläinen EK, Markkanen MH, Mäkelä TH, Wähälä KT, Hase TP and Fotsis T: Soybean phytoestrogen intake and cancer risk. J Nutr 125: 757S-770S, 1995.
14. Gotoh T, Yamada K, Yin H, Ito A, Kataoka T and Dohi K: Chemoprevention of N-nitroso-N- methylurea-induced rat mammary carcinogenesis by soy foods or bichanin-A. Jpn J Cancer Res 89: 137-142, 1998.
15. Sellers TA: Genetic factors in the pathogenesis of breast cancer: Their role and relative importance. J Nut 127: 929S-932S, 1997.
16. Hsieh C-Y, Santell RC, Haslam SZ and Helferich WG, Estrogenic effects of genistein on the growth of estrogen receptor-positive human breast cancer (MCF-7) cells in vitro and in vivo. Cancer Res 58: 3833-3838, 1998.
17. Coward L, Barnes NC, Setchell KDR and Barnes S: Genistein, daidzein, and their ß-glycoside conjugates: Antitumor isoflavones in soybean foods from American and Asian diets. J Agric Food Chem 41: 1961-1967, 1993.
18. Fotsis T, Zhang Y, Pepper MS, Adlercreutz H, Montesano R, Nawrooth PP and Schweigerer L: The endogenous oestrogen metabolite 2-methoxyoestradiol inhibits angiogenesis and suppresses tumor growth, Nature 368: 237-239, 1994.
19. Kondo K, Tsuneizumi K, Watanabe T and Oishi M: Induction of in vitro differentiation of mouse embryonal carcinoma (F9) cells by inhibitors of topoisomerases. Cancer Res 57: 5398-5404, 1991.
20. Rao AV and Sung MK: Saponins as anticarcinogens. J Nutr 125: 717S-724S, 1995.