Vitamin A teratogenicity and risk assessment in the macaque retinoid model

Reproductive Toxicology

Volumn 14, Issue 4, 2000, Pages 311-323

  Hendrickx, A G ^a   Peterson, P ^a   Hartmann, D ^b   Hummler, H ^b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b F HOFFMANN LA ROCHE LTD   (Switzerland)

Author keywords

13 cis retinoic acid; Accutane ; Kinetics; Long tailed macaque; Retinol; Risk assessment; Teratology; Vitamin A

Indexed keywords

ISOTRETINOIN; RETINOIC ACID; RETINOL; RETINOL ESTER; RETINOL PALMITATE; RO 01 5852; TERATOGENIC AGENT;

ABORTION; ANIMAL; ANIMAL EXPERIMENT; ANIMAL MODEL; AREA UNDER THE CURVE; ARTICLE; BODY WEIGHT; CONGENITAL MALFORMATION; CONTROLLED STUDY; DISEASE MODEL; DOSE RESPONSE; DRUG SURVEILLANCE PROGRAM; EMBRYOLOGY; EMBRYOPATHY; FEMALE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; MACACA; METABOLISM; NONHUMAN; ORAL DRUG ADMINISTRATION; PATHOLOGY; PREGNANCY; RISK ASSESSMENT; TERATOGENICITY;

ABNORMALITIES, DRUG-INDUCED; ADMINISTRATION, ORAL; ANIMALS; AREA UNDER CURVE; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; HUMANS; ISOTRETINOIN; MACACA FASCICULARIS; NO-OBSERVED-ADVERSE-EFFECT LEVEL; PREGNANCY; RISK ASSESSMENT; TERATOGENS; VITAMIN A;

ANIMALIA; MACACA; MACACA FASCICULARIS;

EID: 0033856268     PISSN: 08906238     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0890-6238(00)00091-5     Document Type: Article

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