Effects of rifampin on the glutathione depletion and cytochrome c reduction by acetaminophen reactive metabolites in an in vitro P450 enzyme system

Japanese Journal of Pharmacology

Volumn 83, Issue 3, 2000, Pages 182-190

  Huang, R ^a   Okuno, H ^a   Takasu, M ^a   Takeda, S ^a   Kano, H ^a   Shiozaki, Y ^a   Inoue, K ^a  

^a GUANGXI MEDICAL UNIVERSITY   (China)

Author keywords

Acetaminophen; Cytochrome c reduction; GSH depletion; P450; Rifampin

Indexed keywords

CYTOCHROME C; CYTOCHROME P450 ISOENZYME; GLUTATHIONE REDUCTASE; PARACETAMOL; PHENOBARBITAL; RIFAMPICIN; SUPEROXIDE DISMUTASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; COMPETITIVE BEHAVIOR; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOSE RESPONSE; DRUG ANTAGONISM; DRUG EFFECT; DRUG MECHANISM; DRUG METABOLISM; DRUG TISSUE LEVEL; IN VITRO STUDY; LIVER; MALE; METABOLITE; MOUSE; NONHUMAN;

ACETAMINOPHEN; ANIMALS; CYTOCHROME C GROUP; CYTOCHROME P-450 ENZYME SYSTEM; GLUTATHIONE; MALE; MICE; MICE, INBRED ICR; NADPH-FERRIHEMOPROTEIN REDUCTASE; OXIDATION-REDUCTION; RIFAMPIN; SUPEROXIDE DISMUTASE;

EID: 0033854854     PISSN: 00215198     EISSN: None     Source Type: Journal    
DOI: 10.1254/jjp.83.182     Document Type: Article

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