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Volumn 30, Issue 18, 2000, Pages 3391-3404

The preparation of 4,5-dihydro-3-aryl-naphth-[1,2-c]-isoxazoles from dilithiated 1-tetralone oxime and aromatic esters

Author keywords

[No Author keywords available]

Indexed keywords

4,5 DIHYDRO 3 ARYL NAPHTH [1,2 C] ISOXAZOLE DERIVATIVE; ISOXAZOLE DERIVATIVE; UNCLASSIFIED DRUG;

EID: 0033852869     PISSN: 00397911     EISSN: None     Source Type: Journal    
DOI: 10.1080/00397910008086979     Document Type: Article
Times cited : (7)

References (37)
  • 1
    • 0001485034 scopus 로고
    • Potts, K. E., Editor; Pergamon Press, New York, New York
    • a. Lang, Jr., S. A.; Lin, Y.-I. in "Comprehensive Heterocyclic Chemistry", Potts, K. E., Editor; Vol. 6, Part 4B, Pergamon Press, New York, New York, 1984, pp 61-82.
    • (1984) Comprehensive Heterocyclic Chemistry , vol.6 , Issue.PART 4B , pp. 61-82
    • Lang S.A., Jr.1    Lin, Y.-I.2
  • 2
    • 0003540629 scopus 로고
    • R. H. Wiley, Editor, Interscience Publishers, New York, New York, Several recent synthesis reports
    • b. Quilico, A. in "The Chemistry of Heterocyclic Compounds", R. H. Wiley, Editor, Interscience Publishers, New York, New York, 1962, pp 5-35. Several recent synthesis reports:
    • (1962) The Chemistry of Heterocyclic Compounds , pp. 5-35
    • Quilico, A.1
  • 7
    • 0343581484 scopus 로고    scopus 로고
    • See ref. 1a., pp 114-127
    • a. See ref. 1a., pp 114-127.
  • 14
    • 0342711454 scopus 로고
    • Japan Kokkai JP 48099161
    • b. Suzuka, Y., and Minami, N., Japan Kokkai JP 48099161: Chem. Abstr., 1974, 80:95923.
    • (1974) Chem. Abstr. , vol.80 , pp. 95923
    • Suzuka, Y.1    Minami, N.2
  • 35
    • 0003824559 scopus 로고    scopus 로고
    • John Wiley and Sons, Inc., New York, New York
    • The preparation of the oxime from 1-tetralone involved a minor modification of a well documented procedure where 20 g of hydroxylamine hydrochloride was dissolved in 120 mL of water followed by the addition of 80 mL of 10% NaOH solution. The solution was placed in a flask or beaker and heated on a stir plate while 20 g of 1-tetralone dissolved in 30-40 mL of ethanol was added along with enough extra ethanol to affect the solution. The solution was heated just enough to slowly boil off solvents [fume hood], and finally an oily layer/phase appeared. The mixture was refrigerated, and crystallization occurred immediately. After filtration, the solid was recrystallized from ethanol, and it was dry enough after filtration for immediate use [15-20 min.], although use of a vacuum desiccator is recommended, [80-90 % yield after recrystallization from ethanol]. See also: Shriner, R. L., Hermann, C. K. F., Morrill, T. C., Curtin, D. Y., and Fuson, R. C., "The Systematic Identification of Organic Compounds", seventh edition, John Wiley and Sons, Inc., New York, New York, 1997, p. 323.
    • (1997) "The Systematic Identification of Organic Compounds", Seventh Edition , pp. 323
    • Shriner, R.L.1    Hermann, C.K.F.2    Morrill, T.C.3    Curtin, D.Y.4    Fuson, R.C.5
  • 36
    • 0343581480 scopus 로고    scopus 로고
    • note
    • a. Melting points were obtained with a Mel-Temp II melting point apparatus in open capillary tubes and are uncorrected.
  • 37
    • 0343581479 scopus 로고    scopus 로고
    • note
    • b. Combustion analyses for C, H and


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.