The large-scale Munich ENU-mouse-mutagenesis screen

Mammalian Genome

Volumn 11, Issue 7, 2000, Pages 507-510

  Soewarto, Dian ^a   Fella, Christiane ^a   Teubner, Andreas ^a   Rathkolb, Birgit ^b   Pargent, Walter ^a   Heffner, Stephan ^a   Marschall, Susan ^a   Wolf, Eckhard ^b   Balling, Rudi ^a   Hrabé De Angelis, Martin ^a  

^a INSTITUTE OF EPIDEMIOLOGY   (Germany)

^b UNIVERSITY OF MUNICH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ETHYLNITROSOUREA;

ALGORITHM; ARTICLE; CHROMOSOME MAP; DATA BASE; GENETIC SCREENING; MOUSE; MUTAGENESIS; NONHUMAN; PHENOTYPE; SPERM PRESERVATION;

ABNORMALITIES; ANIMALS; CHROMOSOME MAPPING; DATABASES, FACTUAL; DISEASE MODELS, ANIMAL; ETHYLNITROSOUREA; GENETIC DISEASES, INBORN; GENETIC SCREENING; HUMAN GENOME PROJECT; INTERNET; MICE; MICE, MUTANT STRAINS; MUTAGENESIS; MUTAGENS;

EID: 0033852791     PISSN: 09388990     EISSN: None     Source Type: Journal    
DOI: 10.1007/s003350010097     Document Type: Article

References (27)

1. Ashburner M (1989) Drosophila, A Laboratory Handbook. Cold Spring Harbor, N.Y.: Cold Spring Harbor Laboratory Press, pp 343-40.1
2. Bode VC, McDonald JD, Guénet JL, Simon D (1988) hph-1: a mouse mutant with hereditary hyperphenylalaninemia induced by ethylnitrosourea mutagenesis. Genetics 118, 299-305
3. Brown S, Peters J (1996) Combining mutagenesis and genomics in the mouse: closing the phenotype gap. Trends Genet 12, 433-435
4. Dove WF (1987) Molecular genetics of Mus musculus: point mutagenesis and millimorgans. Genetics 116, 5-8.
5. Driever W, Solnica-Krezel L, Schier AF, Neuhauss SC, Malicki J (1996) A genetic screen for mutations affecting embryogenesis in zebrafish. Development 123, 37-16
6. Evans MJ, Carlton MBL, Russ AP (1997) Gene trapping and functional genomics. Trends Genet 13, 370-374
7. Favor J, Neuhäuser-Klaus A, Ehling UH (1990a) The frequency of dominant cataract and recessive specific-locus-mutation mosaics in F1 mice derived from post-spermatogonial treatment with ethylnitrosurea. Mutat Res 229, 105-114
8. Favor J, Sund M, Neuhäuser-Klaus A, Ehling UH (1990b) A dose-response analysis of ethylnitrosourea-induced recessive specific-locus mutations in treated spermatogonia of the mouse. Mutat Res 231, 47-54
9. Haffter P, Granato M, Brand M, Mullins M, Hammerschmidt M et al. (1996) The identification of genes with unique and essential functions in the development of the zebrafish, Danio rerio. Dev Suppl 123(Zebrafish), 1-36
10. Harbach PR, Filipunas AL, Wang Y, Aaron CS (1992). DNA sequence analysis of spontaneous and N-ethyl-N-nitrosurea-induced hprt mutations arising in vivo in cynomolgus monkey T-lymphocytes. Environ Mol Mutagen 20, 96-105
11. Hrabé de Angelis M, Balling R (1998) Large scale ENU screens in the mouse. Genetics meets Genomics. Mutat Res 400, 25-32
12. Marschall S, Hrabé de Angelis M (1999) Cryopreservation of mouse spermatozoa - double your mouse space. Trends Genet 15, 128-131
13. Marschall S, Huffstadt U, Balling R, Hrabé de Angelis M (1999) Reliable recovery of inbred mouse lines using cryopreserved spermatozoa. Mamm Genome 10, 773-776
14. Mullins MC, Hammerschmidt M, Haffter P, Nüsslein-Volhard C (1994) Large-scale mutagenesis in the zebrafish: in search of genes controlling development in a vertebrate. Curr Biol 4, 189-201
15. Nüsslein-Vollhard C, Wieschaus E (1980) Mutations affecting segment number and polarity in Drosophila. Nature 287, 795-801
16. Peters J (1985) Ethylnitrosourea as a mouse mutagen. Trends Genet 1, 5-6
17. Popp RA, Bailiff EG, Skow LC, Johnson FM, Lewis SE (1983) Analysis of a mouse alpha-globin gene mutation induced by ethylnitrosurea. Genetics 105, 157-167
18. Ramirez-Solis R, Davis AC, Bradley A (1993) Gene targeting in embryonic stem cells. Methods Enzymol 225, 855-878
19. Rinchik EM, Carpenter DA, Selby PB (1990) A strategy for fine-structure functional analysis of a 6-to 11-centimorgan region of mouse chromosome 7 by high-efficiency mutagenesis. Proc Natl Acad Sci USA 87, 896-900
20. Rogers DC, Fisher EM, Brown SD, Peters J, Hunter AJ et al. (1997) Behavioral and functional analysis of mouse phenotype: SHIRPA, a proposed protocol for comprehensive phenotype assessment. Mamm Genome 8, 711-713
21. Russell W (1982) Factors affecting mutagenicity of ethylnitrosourea in the mouse specific-locus test and their bearing on risk estimation. In: Environmental Mutagens and Carcinogens: Proceedings of the Third International Conference on Environmental Mutagens
22. Russell WL, Kelly PR, Hunsicker PR, Bangham JW, Maddux SC et al. (1979) Specific-locus test shows ethylnitrosourea to be the most potent mutagen in the mouse. Proc Natl Acad Sci USA 76, 5918-5922
23. Russell LB, Russell WL, Rinchik EM, Hunsicker PR (1990) Factors affecting the nature of induced mutations. Banbury Rep 34, 271-289
24. Schuler GD, Boguski MS, Stewart EA, Stein LD, Gyapay G et al. (1996) A gene map of the human genome. Science 274, 540-546
25. Solnica-Krezel L, Schier AF, Driever W (1994) Efficient recovery of ENU-induced mutations from the zebrafish germline. Genetics 136, 1401-1420
26. Thomas KR, Capecchi MR (1987) Site-directed mutagenesis by gene targeting in mouse embryo-derived stem cells. Cell 51, 503-512
27. Wiles MV, Vauti F, Otte J, Füchtbauer EM, Ruiz P et al. (2000). Establishment of a gene trap sequence tag (GTST) library to generate mutant mice from embryonic stem cells. Nat Genet, in press