Comet assay as a tool to screen for mouse models with inherited radiation sensitivity

Mammalian Genome

Volumn 11, Issue 7, 2000, Pages 552-554

  Schindewolf, Catherine ^a   Lobenwein, Kurt ^a   Trinczek, Korinna ^b   Gomolka, Maria ^b   Soewarto, Dian ^a   Fella, Christiane ^a   Pargent, Walter ^a   Singh, Narendra ^c   Jung, Thomas ^b   Hrabé De Angelis, Martin ^a  

^a INSTITUTE OF EPIDEMIOLOGY   (Germany)

^b BUNDESAMT FÜR STRAHLENSCHUTZ   (Germany)

^c University of Washington   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL CELL; ARTICLE; CHROMOSOME STRUCTURE; COMET ASSAY; DNA REPAIR; GENE ISOLATION; GENETIC SCREENING; GENETIC SUSCEPTIBILITY; LYMPHOCYTE; MOUSE; MUTAGENESIS; NONHUMAN; PROTO ONCOGENE; RADIOSENSITIVITY; TUMOR SUPPRESSOR GENE;

ANIMALS; COMET ASSAY; DISEASE MODELS, ANIMAL; DNA DAMAGE; ETHYLNITROSOUREA; GENETIC SCREENING; LYMPHOCYTES; MICE; MUTAGENESIS; MUTAGENS; RADIATION TOLERANCE; RADIATION, IONIZING;

ANIMALIA; ATAXIA; ATAXIA TELANGIECTASIA; RODENTIA;

EID: 0033852587     PISSN: 09388990     EISSN: None     Source Type: Journal    
DOI: 10.1007/s003350010106     Document Type: Article

References (9)

1. Djuzenova CS, Schlinder D, Stopper H, Hoehn H, Flentje M et al. (1999) Identification of ataxia telangiectasia heterozygotes, a cancer-prone population, using the single-cell gel electrophoresis (Comet) assay. Lab Investig 79, 699-705
2. Hrabé de Angelis M, Balling R (1998) Large-scale ENU screens in the mouse. Genetics meets genomics. Mutat Res 400, 25-32
3. McCurdy D, Tai L-Q, Prias S Wang Z, (1997) Delayed repair of DNA damage by ionizing radiation in cells from patients with juvenile systematic lupus erythematosus and rheumatoid arthritis. Radiat Res 147, 48-54
4. Roberts SA, Spreadborough AR, Bulman B, Barber JBP, Evans DGR et al. (1999) Heritability of cellular radiosensitivity: a marker of low-penetrance predisposition genes in breast cancer?, Am J Hum Genet 65, 784-794
5. Scott D, Barber JBP, Levine EL, Burrill W, Roberts SA, (1998) Radiation-induced micronucleus induction in lymphocytes identifies a high frequency of radiosensitive cases among breast cancer patients: a test for predisposition? Br J Cancer 77, 614-620
6. Singh NP, (1996) Microgel electrophoresis of DNA from individual cells. In Principles and Methodology; Technologies for Detection of DNA Damage ami Mutations GP Pfeifer ed. (New York, Plenum Press), pp 3-24
7. Singh NP, McCoy MT, Tice RR, Schneider EL, (1988) A simple technique for quantitation of low levels of DNA damage in individual cells Exp Cell Res 308, 184-191
8. Singh NP, Graham MM, Singh V Kahn A, (1995) Induction of DNA single-stranded breaks in human lymphocytes by low doses of gamma rays. Int J Radiat Biol 68, 563-569
9. Terzoudi GI, Jung T, Hain J, Vrouvas J, Margaritis K et al. (1999) Increased G2 chromosomal radiosensitivity in cancer patients: the role of cdk1/cyclin B activity level in the mechanisms involved. Int J Radiat Biol, in press