Clinical significance of expression of membrane type 1 matrix metalloproteinase and matrix metalloproteinase-2 in human head and neck squamous cell carcinoma

Human Pathology

Volumn 31, Issue 8, 2000, Pages 895-904

  Imanishi, Yorihisa ^a,b   Fujii, Masato ^a,b   Tokumaru, Yutaka ^a,b   Tomita, Toshiki ^a,b   Kanke, Minoru ^a,b   Kanzaki, Jin ^a,b   Kameyama, Kaori ^a,b   Otani, Yoshihide ^a,b   Sato, Hiroshi ^a,b  

^a KEIO UNIVERSITY   (Japan)

^b KANAZAWA UNIVERSITY   (Japan)

Author keywords

HNSCC; Lymph node metastasis; MMP 2; MT1 MMP; Multivariate logistic regression analysis

Indexed keywords

COLLAGENASE; GELATINASE A; MESSENGER RNA; STROMELYSIN;

ARTICLE; CONTROLLED STUDY; ENZYME ACTIVATION; HEAD CANCER; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; IN SITU HYBRIDIZATION; LYMPH NODE METASTASIS; NECK CANCER; NORTHERN BLOTTING; PROTEIN EXPRESSION; SQUAMOUS CELL CARCINOMA; TISSUE DISTRIBUTION;

EID: 0033851759     PISSN: 00468177     EISSN: None     Source Type: Journal    
DOI: 10.1053/hupa.2000.9756     Document Type: Article

References (37)

1. Cancer metastasis and angiogenesis: An imbalance of positive and negative regulation
2. Metalloproteinase and their inhibitors in matrix remodeling
3. Tumor cell surface-associated binding site for the Mr 72,000 type IV collagenase
4. Tumor cell interactions with the extracellular matrix during invasion and metastasis
5. Proteinases and matrix degradation
6. A matrix metalloproteinase expressed on the cell surface of invasive tumour cells
7. Cell surface binding and activation of gelatinase A induced by expression of membrane-type-1-matrix metalloproteinase (MT1-MMP)
8. cDNA sequence and mRNA tissue distribution of a novel human matrix metalloproteinase with a potential transmembrane segment
9. Identification of the second membrane-type matrix metalloproteinase (MT-MMP-2) gene from a human placenta cDNA library: MT-MMPs from a unique membrane-type subclass in the MMP family
10. Molecular cloning of a novel membrane-type matrix metalloproteinase from a human breast carcinoma
11. Identification and characterization of human MT5-MMP, a new membrane-bound activator of progelatinase A overexpressed in brain tumors
12. Expression of membrane-type matrix metalloproteinase in human gastric carcinomas
13. Analysis of MT1-MMP and MMP2 expression in human gastric cancers
14. Activation of the precursor of gelatinase A /72 kDa type IV collagenase/MMP-2 in lung carcinomas correlates with the expression of membrane-type matrix metalloproteinase (MT-MMP) and lymph node metastasis
15. Expression of matrix metalloproteinase and their inhibitors in human bronchoplumonary carcinomas: Quantificative and morphological analysis
16. Expression and tissue localization of Membrane-type 1, 2, and 3 matrix metalloproteinases in human invasive breast carcinomas
17. MT1-MMP and MMP-2 mRNA expression in human ovarian tumors: Possible implications for the role of desmoplastic fibroblasts
18. Membrane-type matrix metalloproteinase-1 (MT1-MMP) gene is overexpressed in highly invasive hepatocellular carcinomas
19. Increased expression of membrane type 1 matrix metalloproteinase and matrix metalloproteinase-2 with tumor dedifferentiation in hepatocellular carcinomas
20. Enhanced production and activation of progelatinase A mediated by membrane-type 1 matrix metalloproteinase in human papillary thyroid carcinomas
21. Prognostic factors for survival and tumor control in cervical lymph node metastases from head and neck cancer. A multivariate study of 492 cases
22. Lymph node prognostic factors in head and neck squamous cell carcinomas
23. Recurrence at the primary site in head and neck cancer and the significance of neck lymph node metastases as a prognostic factor
24. Membrane-type matrix metalloproteinase (MT-MMP) gene is expressed in stromal cells of human colon, breast, and head and neck carcinomas
25. Increased expression of membrane type-1 matrix metalloproteinases in head and neck carcinoma
26. H-ras oncogene-transformed human bronchial epithelial cells (TBE-1) secrete a single metalloprotease capable of degrading basement membrane collagen
27. Non-radioactive labeling of RNA transcripts in vitro with the hapten digoxigenin (DIG); Hybridization and ELISA-based detection
28. Ethidium bromide fluorescence of 28S ribosomal RNA can be used to normalize samples in northern or dot blots when analyzing small drug-induced changes in specific mRNA
29. Isolation of a mouse MT2-MMP gene from a lung cDNA library and identification of its product
30. Membrane-type matrix metalloproteinase 1 is a gelatinolytic enzyme and is secreted in a complex with tissue inhibitor of metalloproteinases 2
31. Transmembrane-deletion mutants of the membrane-type matrix metalloproteinase-1 process progelatinase A and express intrinsic matrix-degrading activity
32. Membrane type 1 matrix metalloproteinase digests interstitial collagens and other extracellular matrix macromolecules
33. Matrix metalloproteinases regulate neovascularization by acting as pericellular fibrinolysins
34. TIMP-2 promotes activation of progelatinase A by membrane-type 1 matrix metalloproteinase immobilized on agarose beads
35. The TIMP2 membrane type 1 metalloproteinase 'receptor' regulates the concentration and efficient activation of progelatinase A. A kinetic study
36. Matrix metalloproteinase 2 from human synovial fibroblasts: Purification and activation of the precursor and enzymic properties
37. The epithelial to mesenchymal transition and metastatic progression in carcinoma