Suppression of neural activity of bronchial irritant receptors by surface-active phospholipid in comparison with topical drugs commonly prescribed for asthma

Clinical and Experimental Allergy

Volumn 30, Issue 9, 2000, Pages 1266-1274

  Hills, ^a   Chen, ^a  

^a MATER CHILDREN S HOSPITAL   (Australia)

Author keywords

2 Agonists; Asthma; Bronchoconstriction; Corticosteroids; Epithelial barrier; Receptor masking; Surface active phospholipid; Surfactant

Indexed keywords

BETA 2 ADRENERGIC RECEPTOR STIMULATING AGENT; CORTICOSTEROID; DIPALMITOYLPHOSPHATIDYLCHOLINE; PHOSPHATIDYLGLYCEROL; SALBUTAMOL;

ACTION POTENTIAL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ASTHMA; BETA ADRENERGIC STIMULATION; BRONCHOSPASM; BRONCHUS MUCOSA; CONTROLLED STUDY; DRUG EFFECT; NERVE CONDUCTION; NONHUMAN; PRESCRIPTION; PRIORITY JOURNAL; PROVOCATION TEST; RAT; STIMULUS RESPONSE;

ADRENERGIC BETA-AGONISTS; ALBUTEROL; ANIMALS; ANTI-INFLAMMATORY AGENTS; ASTHMA; BRONCHI; BRONCHIAL PROVOCATION TESTS; CHEMORECEPTORS; HYDROCORTISONE; MALE; METHACHOLINE CHLORIDE; PHOSPHOLIPIDS; PULMONARY SURFACTANTS; RATS; RATS, WISTAR; RESPIRATORY MUCOSA; VAGUS NERVE;

EID: 0033851592     PISSN: 09547894     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2222.2000.00850.x     Document Type: Article

References (35)

1. Mechanism of bronchoconstriction during inhalation of dust
2. Asthma: Past, present and future
3. Asthma: Is there an airway receptor barrier?
4. Role of surfactant in the upper respiratory tract
5. Ultrastructural studies on surface lining layer of the lungs: Part IV. Resected human lungs
6. The biology of surfactant
7. The biochemistry of memory: A new and specific hypothesis
8. Dark-induced supersensitivity of dopamine D-1 and D-2 receptors in rat retina
9. Gastric surfactant and the hydrophobic mucosal barrier
10. A mechanism for masking receptors with particular application to asthma
11. The contact angle induced by DPL at pulmonary epithelial surfaces
12. Dexamethasone increases adult lung surfactant lipids
13. Beta adrenergic priming of rats in vivo modulates the effect of beta-agonist in vitro on surfactant phospholipid metabolism of isolated lungs
14. Reproducibility and comparison of responses to inhaled histamine and methacholine
15. Influence of increased surface-actie phospholipid (SAPL) on the response of irritant receptors to stimuli in rats
16. Physical and physiological properties of dry lung surfactant
17. Mechanisms by which histamine stimulates rapidly adapting receptors in dog lungs
18. Can steroids cause asthma to remit?
19. Corticosteroid pharmacokinetics in asthma
20. Adsorption of polar organic compounds on steel
21. Ultra-structural studies on surface lining layer of the lungs
22. Formation of multilamellar vesicles by addition of tannic acid to phosphatidylcholine containing small unilamellar vesicles
23. 'Dewatering' of the lungs at birth
24. Surfactant-like material on the chemoreceptorial surface of the frog's taste organ: An ultra-structural and electron spectroscopic imaging study
25. Gastric mucosal barrier: Barrier to hydrogen ions imparted by gastric surfactant
26. Airway inflammation in symptomatic and asymptomatic children with methacholine hyperresponsiveness
27. Ventilatory function in chronic peptic ulcer. A controlled study of ventilatory function in patients with gastric and duodenal ulcer
28. Virus-induced airway hyperresponsiveness and asthma
29. The link between the nose and lung - Is it the same disease?
30. Enhanced in vivo airway gene transfer via transient modification of host barrier properties with a surface-active agent
31. Suppression of angiotensin H induced contraction of the isolated guinea pig ileum by alveolar surfactants
32. Structural changes in asthma
33. In vitro lymphocyte functions in the presence of bovine surfactant and its phospholipid fractions
34. A pilot study of surfactant inhalation for the treatment of asthmatic attack
35. Surfactant nebulization does not alter airflow obstruction and bronchial responsiveness to histamine in asthmatic children