Challenges posed by non-random missing quality of life data in an advanced-stage colorectal cancer clinical trial

Psycho-Oncology

Volumn 9, Issue 4, 2000, Pages 340-354

  Cunningham, A J ^a   Edmonds, C V I ^a   Phillips, C ^a   Soots, K I ^a   Hedley, D ^a   Lockwood, G A ^a  

^a PRINCESS MARGARET HOSPITAL   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

FLUOROURACIL; FOLINIC ACID;

ADULT; ADVANCED CANCER; AGED; ARTICLE; CLINICAL TRIAL; COLORECTAL CANCER; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIARRHEA; DOSE RESPONSE; EMOTIONAL STABILITY; EMOTIONAL STRESS; FEMALE; FOOT DISEASE; HAND DISEASE; HUMAN; MAJOR CLINICAL STUDY; MALE; PHYSICAL ACTIVITY; QUALITY OF LIFE; RANDOMIZED CONTROLLED TRIAL; STOMATITIS; TREATMENT OUTCOME;

ADULT; AGED; AGED, 80 AND OVER; ANTIMETABOLITES, ANTINEOPLASTIC; BIAS (EPIDEMIOLOGY); CLINICAL TRIALS, PHASE II; CLINICAL TRIALS, PHASE III; COLORECTAL NEOPLASMS; CROSS-SECTIONAL STUDIES; DATA COLLECTION; DATA INTERPRETATION, STATISTICAL; FEMALE; FLUOROURACIL; HUMANS; LONGITUDINAL STUDIES; MALE; MIDDLE AGED; NEOPLASM STAGING; QUALITY OF LIFE; QUESTIONNAIRES; RANDOMIZED CONTROLLED TRIALS; REPRODUCIBILITY OF RESULTS; RESEARCH DESIGN;

EID: 0033849073     PISSN: 10579249     EISSN: None     Source Type: Journal    
DOI: 10.1002/1099-1611(200007/08)9:4<340::AID-PON466>3.0.CO;2-F     Document Type: Article

References (41)

1. A modular approach to quality of life assessment in cancer clinical trials
2. The European organization for research and treatment of cancer QLQ-C30: A quality of life instrument for use in international clinical trials in oncology
3. Quality of life during chemotherapy in patients with symptomatic advanced colorectal cancer
4. Missing quality of life data in cancer clinical trials: Serious problems and challenges
5. Quality of life analyses from vinorelbine (navelbine) clinical trials of women with metastatic breast cancer
6. Quality of life assessment in cancer treatment protocols: Research in issues in protocol development
7. Impact of protracted venous infusion fluorouracil with or without interferon Alfa-2b on tumor response, survival, and quality of life in advanced colorectal cancer
8. Approaches to the analysis of quality of life data: Experiences gained from a Medical Research Council Lung Cancer Working Party palliative chemotherapy trial
9. Biological modulation of protracted infusion of 5-fluorouracil with weekly leucovorin. A dose-seeking clinical trial for patients with disseminated gastrointestinal cancers
10. Phase II study of fluorouracil and its modulation in advanced colorectal cancer: A Southwest Oncology Group study
11. Interpretation of quality of life changes. Commentary
12. The measurement of symptom distress
13. Symptom distress, current concerns, and mood disturbance after diagnosis of life threatening disease
14. Development of a symptom distress scale
15. A randomized clinical trial of home nursing care for lung cancer patients
16. The MOS 36-item short-form health survey (SF-36): II. Psychometric and clinical tests of validity in measuring physical and mental health constructs
17. The MOS 36-item short-form health survey (SF-36): III. Tests of data quality, scaling assumptions and reliability across diverse patient groups
18. Efficacy of intravenous continuous infusion of fluorouracil compared with bolus administration in advanced colorectal cancer
19. Measuring quality of life: An emerging science
20. Ensuring the quality of quality of life data: The Southwest Oncology Group experience
21. Quality of life end points in cancer clinical trials: Review and recommendations
22. Quality of life in advanced prostate cancer: Results of a randomized therapeutic trial
23. Guest editorial: The value of quality of life data in judging patient benefit
24. Report from a National Cancer Institute (USA) workshop on quality of life assessment in cancer clinical trials
25. Superiority of sequential methotrexate, fluorouracil, and leucovorin to fluorouracil alone in advanced symptomatic colorectal carcinoma: A randomized trial
26. Lessons learned from measuring health-related quality of life in oncology
27. Interpreting the significance of changes in health-related quality-of-life scores
28. The modulation of fluorouracil with leucovorin in metastatic colorectal carcinoma: A prospective randomized phase III trial
29. Biochemical modulation of fluorouracil: Evidence of significant improvement of survival and quality of life in patients with advanced colorectal carcinoma
30. Weekly irinotecan (CPT-11), leucovorin (LV), and fluorouracil (FU) is superior to daily X5 LV/FU in patients (PTS) with previously untreated metastatic colorectal cancer (CRC)
31. Randomized comparison of four tools measuring overall quality of life in patients with advanced cancer
32. Guidelines for reporting results of quality of life assessments in clinical trials
33. The MOS Short-form General Health Survey. Reliability and validity in a patient population
34. Functional status and well-being of patients with chronic conditions. Results from the Medical Outcomes Study
35. Statistical analysis of quality of life with missing data in cancer clinical trials
36. The MOS 36-item short-form health survey (SF-36). I. Conceptual framework and item selection
37. Conceptualization and measurement of health for adults in the Health Insurance Study. Model of Health and Methodology
38. Cancer incidence and mortality, 1973-1995
39. Quality of life and persons with melanoma: A pilot study