Mechanism of the inhibitory effect of OPB-9195 [(±)-2-isopropylidenehydrazono-4-oxo-thiazolidin-5-ylacetanilide] on advanced glycation end product and advanced lipoxidation end product formation

Journal of the American Society of Nephrology

Volumn 11, Issue 9, 2000, Pages 1719-1725

  Miyata, T ^a   Ueda, Y ^a   Asahi, K ^a   Izuhara, Y ^a   Inagi, R ^a   Saito, A ^a   Van Ypersele De Strihou, C ^a   Kurokawa, K ^a  

^a University of Tokyo   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

2 ISOPROPYLIDENEHYDRAZONO 4 OXO 5 THIAZOLIDINYLACETANILIDE; 2 ISOPROPYLIDENEHYDRAZONO 4 OXO THIAZOLIDIN 5 YLACETANILIDE; ACETANILIDE DERIVATIVE; AMINE; AMINOGUANIDINE; CARBONYL DERIVATIVE; GLYOXAL; LYSINE DERIVATIVE; MALONALDEHYDE; METHYLGLYOXAL; PENTOSIDINE; SERUM ALBUMIN; THIAZOLIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; DRUG EFFECT; DRUG INHIBITION; DRUG MECHANISM; GLYCATION; LIPID OXIDATION; PERITONEAL DIALYSIS; PRIORITY JOURNAL; UREMIA;

EID: 0033848991     PISSN: 10466673     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (30)

1. Accumulation of carbonyl stress accelerates the formation of pentosidine, an advanced glycation end product: Carbonyl stress in uremia
2. Autooxidation products of both carbohydrates and lipids are increased in uremic plasma: Is there oxidative stress in uremia?
3. Increase in three α,β-dicarbonyl compound levels in human uremic plasma: Specific in vivo determination of intermediates in advanced Maillard reaction
4. Alterations in non-enzymatic biochemistry in uremia: Origin and significance of 'carbonyl stress' in long-term uremic complications
5. Advanced glycosylation end products in patients with diabetic nephropathy
6. Immunohistochemical detection of advanced glycosylation end-products in the peritoneum and its possible pathophysiological role in CAPD
7. Interaction between β2-microglobulin and advanced glycation end products in the development of dialysis-related amyloidosis
8. β2-Microglobulin in renal disease
9. Progression of nephropathy in spontaneous diabetic rat is prevented by OPB-9195, a novel inhibitor of advanced glycation
10. Carbonyl compounds cross-link cellular proteins and activate protein-tyrosine kinase p60(c-Src)
11. 2-Isopropylidenehydrazono-4-oxo-thiazolidin-5-ylacetanilide (OPB-9195) treatment inhibits the development of intimal thickening after balloon injury of rat carotid artery: Role of glycoxidation and lipoxidation reactions in vascular tissue damage
12. Aminoguanidine prevents diabetes-induced arterial wall protein cross-linking
13. Identification of N(ε)-carboxymethyllysine as a degradation product of fructoselysine in glycated protein
14. Effect of diabetes and aging on carboxymethyllysine levels in human urine
15. Age-dependent accumulation of N(ε)-(carboxymethyl)lysine and N(ε)-(carboxymethyl)hydroxylysine in human skin collagen
16. Structure elucidation of a senescence cross-link from human extracellular matrix
17. Accumulation of albumin-linked and free-form pentosidine in circulation of uremic patients with end-stage renal failure: Renal implications in the pathophysiology of pentosidine
18. Chemistry and biochemistry of 4-hydroxynonenal, malondialdehyde and related aldehyde
19. Michael addition-type 4-hydroxy-2-nonenal adducts in modified low-density lipoproteins: Markers for atherosclerosis
20. Heat sterilization of fluids for peritoneal dialysis gives rise to aldehydes
21. 3-Deoxyglucosone, a promoter of advanced glycation end products in fluids for peritoneal dialysis
22. Aminoguanidine inhibits oxidative modification of low density lipoprotein protein and the subsequent increase in uptake by macrophage scavenger receptors
23. Generation of protein carbonyls by glycoxidation and lipoxidation reactions with autoxidation products of ascorbic acid and polyunsaturated fatty acids
24. The peritoneal membrane in chronic peritoneal dialysis
25. Early and advanced glycosylation end products
26. Vascular proliferation and enhanced expression of endothelial nitric oxide synthase in human peritoneum exposed to long-term peritoneal dialysis
27. Glycation and advanced glycation end product formation with icodextrin and dextrose
28. Amino acid-based peritoneal dialysis solutions
29. In vitro formation of advanced glycation end products in peritoneal dialysis fluid
30. Advanced glycation and lipidoxidation of the peritoneal membrane: Respective roles of serum and peritoneal fluid reactive carbonyl compounds