Genistein and curcumin block TGF-β1-induced u-PA expression and migratory and invasive phenotype in mouse epidermal keratinocytes

Nutrition and Cancer

Volumn 37, Issue 1, 2000, Pages 49-54

  Santibanez, J F ^a   Quintanilla, M ^a   Martinez, J ^a  

^a UNIVERSITY OF CHILE   (Chile)

Author keywords

[No Author keywords available]

Indexed keywords

CURCUMIN; FIBRONECTIN; GENISTEIN; PROTEIN TYROSINE KINASE; TRANSFORMING GROWTH FACTOR BETA1; UROKINASE;

ANIMAL CELL; ARTICLE; CANCER GROWTH; CELL INVASION; CELL MIGRATION; CELL TRANSFORMATION; CONCENTRATION RESPONSE; EARLY RESPONSE GENE; ENZYME INHIBITION; KERATINOCYTE; MOUSE; NEWBORN; NONHUMAN; PROTEIN SYNTHESIS; SIGNAL TRANSDUCTION;

ANIMALIA;

EID: 0033848437     PISSN: 01635581     EISSN: None     Source Type: Journal    
DOI: 10.1207/S15327914NC3701_6     Document Type: Article

References (29)

1. 1 induces an epithelial-mesenchymal transdifferentiation and a spindle tumoral phenotype
2. 1 induces squamous carcinoma cell variants with increased metastatic abilities and a disorganized cytoskeleton
3. Urokinase expression and binding activity associated with the transforming growth factor-β-induced migratory and invasive phenotype of mouse epidermal keratinocytes
4. Identification of candidate cancer chemopreventive agents and their evaluation in animal models and human clinical trials: A review
5. Biochemical targets of the isoflavone genistein in tumor cell lines
6. Chemoprevention effect of tumeric against stomach and skin tumors induced by chemical carcinogens in Swiss mice
7. Protein-tyrosine kinase inhibitors
8. Cancer chemoprevention agent development strategies for genistein
9. Supression of c-Jun/AP-1 activation by an inhibitor of tumor promotion in mouse fibroblast cells
10. Characteristics of chemically transformed mouse epidermal cells in vitro and in vivo
11. Rearrangements of desmosomal and cytoskeletal proteins during the transition from epithelial to fibroblastoid organization in cultured rat bladder carcinoma cells
12. Bone extracellular matrix stimulates invasiveness of estrogen-responsive human mammary MCF-7 cells
13. Cell adhesion and tumor progression in mouse skin carcinogenesis: Increased synthesis and organization of fibronectin is associated with the undifferentiated spindle phenotype
14. TGF-β-induced transdifferentiation of mammary epithelial cells to mesenchymal cells: Involvement of type I receptors
15. Naturally occurring anticarcinogenic substances in foodstuffs
16. Genistein exerts multiple suppressive effects on human breast carcinoma
17. Genistein inhibits proliferation and in vitro invasive potential of human prostatic cancer cell lines
18. Protective single/combined treatment with betel leaf and turmeric against methyl(acetoxymethyl)nitrosamine-induced hamster oral carcinogenesis
19. Inhibitory effect of curcumin, chlorogenic acid and ferulic acid on tumor promotion in mouse skin by 12-O-tetradecanoylphorbol-13-acetate
20. Curcumin inhibits tyrosine kinase activity of p185neu and also depletes p185neu
21. Plasminogen activation by receptor-bound urokinase
22. Regulation of integrin function by the urokinase receptor
23. Transforming growth factor-β and fibroblast growth factor as promoters of tumor progression to malignancy
24. 1 signal transduction
25. Transforming growth factor-β signaling in epithelial cells
26. Smad2 transduces common signals from receptor serine-threonine and tyrosine kinases
27. Phosphotyrosine inhibition and control of vascular endothelial cell proliferation by genistein
28. The urokinase-type plasminogen activator receptor mediates tyrosine phosphorylation of focal adhesion proteins and activation of mitogen-activated protein kinase in cultured endothelial cells
29. 2 integrins, and Src-kinases within a single receptor complex of human monocytes