Functional impairment of sinusoidal membrane transport of organic cations in rats with CCI4-induced hepatic failure

Pharmaceutical Research

Volumn 17, Issue 7, 2000, Pages 833-838

  Hong, Soon Sun ^a   Chung, Suk Jae ^a   Shim, Chang Koo ^a  

^a Seoul National University   (South Korea)

Author keywords

CCl4; Efflux; Excretion; Hepatocytes; Organic cations (OCs); Uptake

Indexed keywords

CARBON TETRACHLORIDE; CATION; ORGANIC COMPOUND; TRIBUTYLMETHYLAMMONIUM; TRIETHYLMETHYLAMMONIUM; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; DRUG BILE LEVEL; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG TISSUE LEVEL; DRUG TRANSPORT; DRUG UPTAKE; IN VITRO STUDY; IN VIVO STUDY; LIVER; LIVER CELL; LIVER FAILURE; LIVER SINUSOID; MALE; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMALS; CARBON TETRACHLORIDE; CATIONS; HEPATOCYTES; LIVER FAILURE; MALE; QUATERNARY AMMONIUM COMPOUNDS; RATS; RATS, SPRAGUE-DAWLEY;

EID: 0033847666     PISSN: 07248741     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1007508325512     Document Type: Article

References (13)

1. Hepatobiliary elimination of cationic drugs: The role of P-glycoproteins and other ATP-dependent transporters
2. Carbon tetrachloride hepatotoxicity
3. Effect of carbon tetrachloride on the metabolism, storage, and excretion of sulfobromophthalein
4. Effect of carbon tetrachloride-induced liver damage on hepatic transport of ouabain in the rat
5. Effects of carbon tetrachloride and chloroform on bile acid transport in isolated rat hepatocytes: Relationship to elevated serum bile acids
6. Pharmacokinetics of indocyanin green in rats with experimentally induced hepatic diseases
7. Canalicular membrane transport is primarily responsible for the difference in hepatobiliary excretion of triethylmethylammonium and tributylmethyl ammonium in rats
8. Organic cation transporters in intestine, kidney, liver, and brain
9. Different activity of ATP dependent transport across the canalicular membrane for tribultylmethylammonium and triethylmethyl ammonium as a potential mechanism of the preferential biliary excretion for tributylmethylammonium in the rat
10. Structure-pharmacokinetics relationship of quarternary ammonium compounds
11. Hepatic uptake and biliary excretion of organic cations-I. Characterization of three new model compounds
12. New concepts of mechanisms of hepatocyte bile formation
13. Expression of multidrug resistance genes in rat liver during regeneration and after carbon tetrachloride intoxication