In vivo specific binding characteristics and pharmacokinetics of a 1,4-dihydropyridine calcium channel antagonist in the senescent mouse brain

Pharmaceutical Research

Volumn 17, Issue 7, 2000, Pages 844-850

  Uchida, Shinya ^a,b   Yamada, Shizuo ^a   Deguchi, Yoshiharu ^a   Yamamoto, Minoru ^c   Kimura, Ryohei ^a  

^a UNIVERSITY OF SHIZUOKA   (Japan)

^b HAMAMATSU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^c ASTELLAS PHARMA INC   (Japan)

Author keywords

(+) 3H PN 200 110; 1,4 dihydropyridine calcium channel antagonist; Brain concentration; In vivo receptor binding; Pharmacokinetics; Senescence accelerated prone mouse

Indexed keywords

1,4 DIHYDROPYRIDINE; BRAIN RECEPTOR; CALCIUM CHANNEL BLOCKING AGENT; ISRADIPINE;

AGING; ANIMAL EXPERIMENT; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; BRAIN BLOOD FLOW; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG BRAIN LEVEL; DRUG CLEARANCE; DRUG DISTRIBUTION; DRUG HALF LIFE; DRUG PROTEIN BINDING; DRUG RECEPTOR BINDING; DRUG TISSUE LEVEL; HEART; IN VITRO STUDY; IN VIVO STUDY; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL;

AGING; ANIMALS; BRAIN; CALCIUM CHANNEL BLOCKERS; DIHYDROPYRIDINES; ISRADIPINE; MALE; MICE; MYOCARDIUM;

EID: 0033847484     PISSN: 07248741     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1007512426420     Document Type: Article

References (30)

1. A new murine model of accelerated senescence
2. Age-related changes in learning and memory in the senescence-accelerated mouse (SAM)
3. Age-related deterioration of ability of acquisition in memory and learning in senescence accelerated mouse: SAM-P/8 as an animal model of disturbances in recent memory
4. Systemic senile amyloid in senescence-accelerated mouse. A unique fibril protein demonstrated in tissues from various organs by unlabeled immunoperoxidase method
5. 3H]nitrendipine to cerebral cortical and hippocampal membranes of senescence accelerated mouse
6. Neurochemical changes related to ageing in the senescence-accelerated mouse brain and the effect of chronic administration of nimodipine
7. Alterations in calcium antagonist receptors and calcium content in senescent brain and attenuation by nimodipine and nicardipine
8. 2+ homeostasis in dementia
9. Calcium antagonists in the elderly
10. Clinical pharmacokinetics of isradipine
11. Bioavailability of isradipine in young and old rats: Effect of mode of administration
12. Absorption, distribution and excretion of nilvadipine, a new dihydropyridine calcium antagonist, in rats and dogs
13. A sustained occupancy in vivo of cardiovascular calcium antagonist receptors by mepirodipine and its relation to pharmacodynamic effect in spontaneously hypertensive rats
14. The receptor occupation and plasma concentration of NKY-722, a water-soluble dihydropyridine-type calcium antagonist, in spontaneously hypertensive rats
15. A pharmacokinetic analysis program (MULTI) for microcomputer
16. Repeated swim stress alters brain benzodizepine receptors measured in vivo
17. 14]iodoantipyrine in the mouse
18. Nonlinear tissue disposition: Salicylic acid in rat brain
19. Effect of probenecid on the renal and nonrenal clearances of zidovudine and its distribution into cerebrospinal fluid in the rabbit
20. Nimodipine levels in gerbil brain following parenteral drug administration
21. Brain pharmacokinetics and in vivo receptor binding of 1,4-dihydropyrine calcium channel antagonists
22. Certain calcium channel blockers bind specifically to multidrug-resistant human KB carcinoma membrane vesicles and inhibit drag binding to P-glycoprotein
23. Azidopine noncompetitively interacts with vinblastine and cyclosporin A binding to P-glycoprotein in multidrug resistance cells
24. P-glycoprotein as the drug efflux pump in primary cultured bovine brain capillary endothelial cells
25. P-glycoprotein expression and regulation: Age-related changes and potential effects on drug therapy
26. Examples of homospecific and heterospecific receptor regulation
27. Water, electrolytes contents of the brain and cerebral function in aged rats
28. 3H]Nitrendipine binding in temporal cortex in Alzheimer's and Huntington's diseases