Preliminary evaluation of an in vitro test for assessment of excitotoxicity by measurement of early gene (c-fos mRNA) levels

Toxicology in Vitro

Volumn 14, Issue 5, 2000, Pages 447-458

  Griffiths, R ^a   Grieve, A ^a   Scollon, J ^a   Scott, M ^b   Williams, C ^c   Meredith, C ^b  

^a UNIVERSITY OF ST ANDREWS   (United Kingdom)

^b TNO BIBRA Intl Ltd W   (United Kingdom)

^c TRINITY COLLEGE DUBLIN   (Ireland)

Author keywords

c fos mRNA; Cerebellar granule cells; Early gene levels; Excitotoxicity; Predictive test

Indexed keywords

AMINO ACID RECEPTOR BLOCKING AGENT; BIOLOGICAL MARKER; EXCITOTOXIN; GLUTAMATE RECEPTOR; GLUTAMATE RECEPTOR ANTAGONIST; MESSENGER RNA;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; CYTOTOXICITY; GENE ACTIVATION; GENE EXPRESSION; GRANULE CELL; MOUSE; NERVE CELL NECROSIS; NONHUMAN; ONCOGENE C FOS; TOXICITY TESTING;

ANIMALS; CELL DEATH; CELL SURVIVAL; CELLS, CULTURED; CEREBELLAR CORTEX; DOSE-RESPONSE RELATIONSHIP, DRUG; EVALUATION STUDIES; EXCITATORY AMINO ACID ANTAGONISTS; GENE EXPRESSION REGULATION; GENES, FOS; GLUTAMIC ACID; MICE; PROTO-ONCOGENE PROTEINS C-FOS; RNA, MESSENGER;

ANIMALIA;

EID: 0033846448     PISSN: 08872333     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0887-2333(00)00034-5     Document Type: Article

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