Can we screen high-risk individuals to detect early pancreatic carcinoma?

Journal of Surgical Oncology

Volumn 74, Issue 4, 2000, Pages 243-248

  Goggins, Michael ^a   Canto, Mimi ^a   Hruban, Ralph ^a  

^a DEPARTMENT OF PATHOLOGY   (United States)

Author keywords

BRCA2; DNA methylation; Endoscopic ultrasound; Familial pancreatic cancer; Hereditary pancreatitis; p16; Screening; Telomerase

Indexed keywords

BRCA2 PROTEIN; PROTEIN P16; TELOMERASE; TRYPSINOGEN; TUMOR MARKER;

CANCER DIAGNOSIS; CANCER SCREENING; CANCER SURGERY; CANCER SUSCEPTIBILITY; DNA METHYLATION; EARLY DIAGNOSIS; ENDOSCOPIC RETROGRADE CHOLANGIOPANCREATOGRAPHY; FAMILIAL CANCER; HEREDITY; HIGH RISK POPULATION; HUMAN; PANCREAS CARCINOMA; PANCREATITIS; PRIORITY JOURNAL; REVIEW; RISK FACTOR;

ENDOSONOGRAPHY; FEMALE; GENETIC DISEASES, INBORN; GERM-LINE MUTATION; HUMANS; MALE; MASS SCREENING; PANCREATIC NEOPLASMS; RISK ASSESSMENT; SENSITIVITY AND SPECIFICITY; TUMOR MARKERS, BIOLOGICAL;

EID: 0033845951     PISSN: 00224790     EISSN: None     Source Type: Journal    
DOI: 10.1002/1096-9098(200008)74:4<243::AID-JSO1>3.0.CO;2-C     Document Type: Review

References (52)

1. Pancreaticoduodenectomy for cancer of the head of the pancreas: 201 Patients
2. Familial pancreatic cancer: A review
3. Reported family aggregation of pancreatic cancer within a population- based case-control study in the Francophone community in Montreal, Canada
4. Diabetes mellitus, other medical conditions and familial history of cancer as risk factors for pancreatic cancer
5. Germline BRCA2 gene mutations in patients with apparently sporadic pancreatic carcinomas
6. Germline BRCA2 6174delT mutations in Ashkenazi Jewish pancreatic cancer patients
7. Genetics of pancreatic cancer. From genes to families
8. Increased risk of pancreatic cancer in melanoma-prone kindreds with p16INK4 mutations
9. Increased risk of cancer in the Peutz-Jeghers syndrome
10. Early diagnosis and treatment of pancreatic dysplasia in patients with a family history of pancreatic cancer
11. Staging of pancreatic and ampullary carcinoma by endoscopic ultrasonography. Comparison with conventional sonography, computed tomography, and angiography
12. Optimal interpretation of FDG PET in the diagnosis, staging and management of pancreatic carcinoma
13. Intensified adjuvant therapy for pancreatic and periampullary adenocarcinoma: Survival results and observations regarding patterns of failure, radiotherapy dose and CA19-9 levels
14. CA 19-9 in pancreatic cancer
15. Pathology of incipient pancreatic cancer
16. Mutational activation of K-ras in nonneoplastic exocrine pancreatic lesions in relation to cigarette smoking status
17. Usefulness of novel tumour markers
18. Role of tumor markers and mutations in cells and pancreatic juice in the diagnosis of pancreatic cancer
19. Most human carcinomas of the exocrine pancreas contain mutant c-K-ras genes
20. K-ras oncogene activation in adenocarcinomas of the human pancreas: A study of 82 carcinomas using a combination of mutant-enriched polymerase chain reaction analysis and allele-specific oligonucleotide hybridization
21. Detection of K-ras mutations in the stool of patients with pancreatic adenocarcinoma and pancreatic ductal hyperplasia
22. The role of Ras mutation in pancreatic cancer, precancerous lesions, and chronic pancreatitis
23. A prospective study of K-ras mutations in the plasma of pancreatic cancer patients
24. Detection of K-ras gene mutations in plasma DNA of patients with pancreatic adenocarcinoma: Correlation with clinicopathological features
25. Specific association of human telomerase activity with immortal cells and cancer
26. Telomerase activity in the differential diagnosis of papillary carcinoma of the thyroid
27. Human telomerase reverse transcriptase (hTERT) gene expression in thyroid neoplasms
28. Telomerase activity in pancreatic juice differentiates ductal carcinoma from adenoma and pancreatitis
29. Telomerase activity detected in pancreatic juice 19 months before a tumor is detected in a patient with pancreatic cancer
30. In situ hybridization for telomerase RNA in routine cytologic brushings for the diagnosis of pancreaticobiliary malignancies
31. Telomerase activity for the preoperative diagnosis of pancreatic cancer
32. Detection of telomerase activity in breast masses by fine-needle aspiration
33. Telomerase activity in lesions of the thyroid: Application to diagnosis of clinical samples including fine-needle aspirates
34. Islet amyloid polypeptide in patients with pancreatic cancer and diabetes
35. Serial analysis of gene expression
36. Gene expression profiles in normal and cancer cells
37. TIMP-1 as a diagnostic marker for pancreatic cancer
38. Use of a cDNA microarray to analyse gene expression patterns in human cancer
39. Aberrant methylation of p16(INK4a) is an early event in lung cancer and a potential biomarker for early diagnosis
40. DNA hypermethylation in pancreatic carcinoma
41. K-ras mutations in the duodenal fluid of patients with pancreatic carcinoma
42. Use of aspirin and other nonsteroidal anti-inflammatory drugs and risk of esophageal and gastric cancer
43. Aspirin and reduced risk of esophageal carcinoma
44. Aspirin use and reduced risk of fatal colon cancer
45. Aspirin use and risk of fatal cancer
46. Use of nonsteroidal anti-inflammatory drugs and incidence of colorectal cancer: A population-based study
47. Nonsteroidal antiinflammatory drug use and reduced risk of large bowel carcinoma
48. Reduced risk of large-bowel adenomas among aspirin users
49. Treatment of colonic and rectal adenomas with sulindac in familial adenomatous polyposis
50. Cyclooxygenase-2 expression is up-regulated in human pancreatic cancer
51. Increased cyclooxygenase-2 expression in human pancreatic carcinomas and cell lines: Growth inhibition by nonsteroidal anti-inflammatory drugs
52. Hereditary pancreatitis and the risk of pancreatic cancer