Inhibiting proteasome activity causes overreplication of DNA and blocks entry into mitosis in sea urchin embryos

Journal of Cell Science

Volumn 113, Issue 15, 2000, Pages 2659-2670

  Kawahara, H ^a   Philipova, R ^a   Yokosawa, H ^a   Patel, R ^a   Tanaka, K ^a   Whitaker, M ^a  

^a NEWCASTLE UNIVERSITY   (United Kingdom)

Author keywords

DNA synthesis; Mitosis; P34(cdc2) kinase; Proteasome; Sea urchin embryo

Indexed keywords

ALDEHYDE; CAFFEINE; PEPTIDE; PROTAMINE KINASE; PROTEASOME; PROTEIN KINASE; THYMIDINE; TYROSINE;

ANIMAL CELL; ARTICLE; CELL CYCLE S PHASE; CELL NUCLEUS MEMBRANE; CONTROLLED STUDY; DEPHOSPHORYLATION; DNA REPLICATION; DNA SYNTHESIS; EMBRYO; ENZYME ACTIVATION; ENZYME INHIBITION; MITOSIS; NONHUMAN; PRIORITY JOURNAL; SEA URCHIN;

ANIMALS; CAFFEINE; CDC2 PROTEIN KINASE; CELL DIVISION; CELL NUCLEUS; CYSTEINE ENDOPEPTIDASES; DNA REPLICATION; EMBRYO, NONMAMMALIAN; EMETINE; FEMALE; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GENE EXPRESSION REGULATION, ENZYMOLOGIC; LEUPEPTINS; MITOSIS; MULTIENZYME COMPLEXES; NUCLEAR ENVELOPE; PHENOTYPE; PHOSPHODIESTERASE INHIBITORS; PHOSPHORYLATION; PHOSPHOTYROSINE; PROTEASE INHIBITORS; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEIN KINASES; PROTEIN SYNTHESIS INHIBITORS; S PHASE; SEA URCHINS; THYMIDINE; TRITIUM;

ANIMALIA; ECHINOIDEA; INVERTEBRATA;

EID: 0033845768     PISSN: 00219533     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (89)

1. Changes in intracellular localization of proteasomes in immortalized ovarian granulosa cells during mitosis associated with a role in cell cycle control
2. Regulation of mitotic inhibitor Mik 1 helps to enforce the DNA damage checkpoint
3. Cdc 18 transcription and proteolysis couple S phase to passage through mitosis
4. A human homologue of the checkpoint kinase Cds1 directly inhibits Cdc25 phosphatase
5. Caffeine inhibits the checkpoint kinase ATM
6. Chromosome replication in Xenopus egg extracts
7. Control of 3T3 cell proliferation by calcium
8. The ubiquitin-proteasome proteolytic pathway
9. An ESP1/PDS1 complex regulates loss of sister chromatid adhesion at metaphase to anaphase transition in yeast
10. Anaphase initiation in Saccharomyces cerevisiae is controlled by the APC-dependent degradation of the anaphase inhibitor Pds1p
11. p25rum1 orders S phase and mitosis by acting as an inhibitor of the p34 cdc2 mitotic kinase
12. Structure and functions of the 20S and 26S proteasomes
13. S phase-promoting cyclin dependent kinases prevent re-replication by inhibiting the transition of replication origins to a pre-replicative state
14. PA700, an ATP-dependent activator of the 20S proteasome, is an ATPase containing multiple members of a nucleotide-binding protein family
15. Inhibition of ubiquitin-mediated proteolysis by the Arabidopsis 26 S protease subunit S5a
16. Replication control: Choreographing replication origins
17. Effect of reduced protein synthesis on the cell cycle in sea urchin embryos
18. The role of S. cerevisiae cell division cycle genes in nuclear fusion
19. Cell cycle checkpoints: Preventing an identity crisis
20. The MO15 gene encodes the catalytic subunit of a protein kinase that activates cdc2 and other cyclin-dependent kinases through phosphorylation of Thr161 and its homologues
21. A single fission yeast mitotic cyclin B p34 cdc2 kinase promotes both S phase and mitosis in the absence of G1 cyclins
22. Cut2 proteolysis required for sister-chromated separation in fission yeast
23. Active cyclinB-cdc2 kinase does not inhibit DNA replication and cannot drive prematurely-fertilized sea urchin eggs into mitosis
24. S. cerevisiae 26S protease mutants arrest cell division in G2/metaphase
25. Cyclin is degraded by the ubiquitin pathway
26. The mechanism and functions of ATP-dependent proteases in bacterial and animal cells
27. Defective mitosis due to a mutation in the gene for a fission yeast 26 S protease subunit
28. A conditional lethal mutant in the fission yeast 26S protease subunit mts3+ is defective in metaphase to anaphase transition
29. + protein kinase regulates entry into mitosis
30. MPF localization is controlled by nuclear export
31. Temporal order of S phase and mitosis in fission yeast is determined by the state of the p34(cdc2)/Mitotic B cyclin complex
32. Proteasomes: Destruction as a program
33. Phosphorylation and activation of human cdc25-C by cdc2-cyclin B and its involvement in the self-amplification of MPF at mitosis
34. Activation of the multicatalytic protease. The 11S regulator and 20S ATPase complexes contain distinct 30-kilodalton subunits
35. Anaphase is initiated by proteolysis rather than by the inactivation of maturation-promoting factor
36. The requirements for protein synthesis and degradation, and the control of destruction of cyclin A and B in the meiotic and mitotic cell cycles of the clam embryo
37. Multiple proteolytic systems, including the proteasome, contribute to CFTR processing
38. Cdc34 and the F-box protein Met30 are required for degradation of the cdk-inhibitory kinase Swe1
39. The 26S proteasome is activated at two points in the ascidian cell cycle
40. Cell cycle-dependent change of proteasome distribution during embryonic development of the ascidian Halocynthia roretzi
41. Intracellular calcium mobilization regulates the activity of 26S proteasome during metaphase-anaphase transition in the ascidian meiotic cell cycle
42. Proteasomes: The protein death machinery
43. How proteolysis drives the cell cycle
44. Ninlp, a regulatory subunit of the 26S proteasome, is necessary for activation of cdc28p kinase of Saccharomyces cerevisiae
45. Yeast counterparts of multiubiquitin receptor and p58 subunit of the human 26S proteasome are encoded by two multicopy suppressers of nin-1
46. The cdc25 protein controls tyrosine dephosphorylation of the cdc2 protein in a cell-free system
47. The Xenopus Chk1 protein kinase mediates a caffeine-sensitive pathway of checkpoint control in cell-free extracts
48. Chromosome replication in early development of Xenopus laevis
49. Mechanism by which caffeine potenciates lethality of nitrogen mustard
50. Proteasome inhibitors: Valuable new tools for cell biologists
51. Nuclear localization of cdc25 is regulated by DNA damage and a 14-3-3 protein
52. Cyclin is a component of the sea urchin egg M-phase specific histone HI kinase
53. Coupling of mitosis to the completion of S phase through cdc34-mediated degradation of weel
54. The role of cyclin synthesis, modification and destruction in the control of cell division
55. Reversible tyrosine phosphorylation of cdc2: Dephosphorylation accompanies activation during entry into mitosis
56. p65(cdc18) plays major role controlling the initiation of DNA replication in fission yeast
57. Regulatory phosphorylation of the p34(cdc2) protein kinase in vertebrates
58. Universal control mechanism regulating onset of M-phase
59. Relocation and distinct subcellular localization of p34cdc2-cyclin B complex at meiosis reinitiation in starfish oocytes
60. ATP-dependent reversible association of proteasomes with multiple protein components to form 26S complexes that degrade ubiquitinated proteins in human HL-60 cells
61. Role of the ubiquitin-proteasome pathway in regulating abundance of the cyclin-dependent kinase inhibitor p27
62. Changes in proteasome localization during the cell cycle
63. Calcium, cyclin and cell cycle control in sea urchin embryos
64. Caffeine overrides the S phase cell cycle block in sea urchin embryos
65. Calcium/calmodulin-dependent phosphorylation and activation of human Cdc25-C at the G2/M phase transition in HeLa cells
66. Joining the complex: Cyclin-dependent kinase inhibitory proteins and the cell cycle
67. Human cyclins A and B1 are differentially located in the cell and undergo cell cycle-dependent nuclear transport
68. The cdc2-related protein p40(MO15) is the catalytic subunit of a protein kinase that can activate p33(cdk2) and p34(cdc2)
69. The multicatalytic and 26S proteases
70. A mutation in a novel yeast proteasomal gene, RPN11/MPR1, produces a cell cycle arrest, overreplication of nuclear and mitochondrial DNA, and an altered mitochondrial morphology
71. Proteasome location
72. Inhibitors of the proteasome block the degradation of most cell proteins and the generation of peptides presented on NMC class I molecules
73. Caffeine-induced uncoupling of mitosis from the completion of DNA replication in mammalian cells
74. The B-type cyclin kinase inhibitor p40(sic1) controls the G1 to S transition in S. cerevisiae
75. Cyclin activation of p34(cdc2)
76. Role of phosphorylation in p34(cdc2) activation: Identification of an activating kinase
77. CAK, the p34(cdc2) activating kinase contains a protein identical or closely related to p40(MO15)
78. Cell cycle control of DNA replication
79. The 20S Proteasome: Subunits and functions
80. Loading of an Mcm protein onto DNA replication origins is regulated by cdc6p and CDKs
81. Inhibition of the chymotrypsin-like activity of pituitary multicatalytic proteinase complex
82. The timing of synthesis of proteins required for mitosis in the cell cycle of the sea urchin embryo
83. Cellular responses to DNA damage
84. Caffeine can override the S-M checkpoint in fission yeast
85. Replication timing: Histone genes replicate during early S phase in cleavage-stage embryos of sea urchin
86. The relation between the increase in reduced nicotinamide nucleotides and the initiation of DNA synthesis in sea urchin eggs
87. Calcium and cell cycle control
88. Localization of the 26S proteasome during mitosis and meiosis in fission yeast
89. Maintenance of G2 arrest in the Xenopus oocyte: A role for 14-3-3-mediated inhibition of cdc25 nuclear import