Hepatocarcinogenesis in female mice with mosaic expression of connexin32

Hepatology

Volumn 32, Issue 3, 2000, Pages 501-506

  Moennikes, Oliver ^a   Buchmann, Albrecht ^a   Willecke, Klaus ^b   Traub, Otto ^b   Schwarz, Michael ^a  

^a Institut fur Toxikologie   (Germany)

^b UNIVERSITY OF BONN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CONNEXIN 32; GLUCOSE 6 PHOSPHATASE; KI 67 ANTIGEN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL PROLIFERATION; CHROMOSOME MOSAICISM; CONTROLLED STUDY; FEMALE; GAP JUNCTION; GENE EXPRESSION; IMMUNOHISTOCHEMISTRY; LIVER CARCINOGENESIS; LIVER CELL; LIVER TUMOR; MOUSE; NONHUMAN; ONCOGENE C JUN; PRIORITY JOURNAL; PROTEIN EXPRESSION; X CHROMOSOME;

EID: 0033844105     PISSN: 02709139     EISSN: None     Source Type: Journal    
DOI: 10.1053/jhep.2000.16598     Document Type: Article

References (30)

1. Connections with connexins: The molecular basis of direct intercellular signaling
2. The gap junction communication channel
3. Intercellular communication: A paradigm for the interpretation of the initiation/promotion/ progression model of carcinogenesis
4. Gap juntional intercellular communication and carcinogenesis
5. Non-genotoxic mechanisms of carcinogenesis: Studies of cell transformation and gap junctional intercellular communication
6. Role of connexin genes in growth control
7. High incidence of spontaneous and chemically induced liver tumors in mice deficient for connexin32
8. The effect of connexin32 null mutation on hepatocarcinogenesis in different mouse strains
9. Sequential changes of gap-junctional intercellular communication during multistage rat liver carcinogenesis: Direct measurement of communication in vivo
10. Altered homologous and heterologous gap-junctional intercellular communication in primary human liver tumors associated with aberrant protein localization but not gene mutation of connexin32
11. Reduced number of gap junctions in rat hepatocarcinomas detected by monoclonal antibody
12. Multiple mechanisms are responsible for altered expression of gap junction genes during oncogenesis in rat liver
13. Gap-junction protein gene suppresses tumorigenicity
14. Cell culture assays for chemicals with tumor-promoting or tumor-inhibiting activity based on the modulation of intercellular communication
15. Performance of tests for cell transformation and gap-junctional intercellular communication for detecting nongeno-toxic carcinogenic activity
16. Two homologous protein components of hepatic gap junctions
17. Six genes of the human connexin gene family coding for gap junctional proteins are assigned to four different human chromosomes
18. Defective propagation of signals generated by sympathetic nerve stimulation in the liver of connexin32-deficient mice
19. Histochemistry of hepatic phosphatases at a physiological pH
20. Regulation and expression of four cytochrome P-450 isoenzymes, NADPH-cytochrome P-450 reductase, the glutathione transferases B and C and microsomal epoxide hydrolase in preneo-plastic and neoplastic lesions in rat liver
21. Gap junctions in several tissues share antigenic determinants with liver gap junctions
22. Heterogeneity of enzyme-altered foci in rat liver
23. Application of quantitative stereology to the evaluation of enzyme-altered foci in rat liver
24. Ki-67 immunoexpression is a robust marker of proliferative cells in the rat
25. c-Jun expression in single cells and preneoplastic foci induced by diethylnitrosamine in B6C3F1 mice: Comparison with the expression of pi-class glutathione S-transferase
26. Clonal growth of carcinogen-induced enzyme deficient preneoplastic cell population in mouse liver
27. Direct evidence for the single cell origin of mouse liver cell tumours
28. Role of mutations at codon 61 of the c-Ha-ras gene during diethylnitrosamine-induced hepatocarcinogenesis in C3H/He mice
29. Methylation and sequence analysis around EagI sites: Indentification of 28 new CpG islands in XQ24-XQ28
30. The role of DNA methylation in cancer genetic and epigenetics