Improved titers of HIV-based lentiviral vectors using the SRV-1 constitutive transport element

Gene Therapy

Volumn 7, Issue 16, 2000, Pages 1421-1424

  Mautino, M R ^a   Keiser, N ^a   Morgan, R A ^a  

^a NATIONAL HUMAN GENOME RESEARCH INSTITUTE   (United States)

Author keywords

CTE; Gene therapy; HIV AIDS; Lentiviral vector; Rev independent

Indexed keywords

REV PROTEIN; VIRUS VECTOR;

ARTICLE; BINDING SITE; CONTROLLED STUDY; DNA MODIFICATION; DNA PACKAGING; GENE LOCATION; GENE MUTATION; GENE SEQUENCE; GENE THERAPY; HELPER VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1; LENTIVIRINAE; LONG TERMINAL REPEAT; MARKER GENE; NONHUMAN; PRIORITY JOURNAL; RNA SPLICING; TRANSPOSON;

HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1; LENTIVIRUS; RNA VIRUSES; SIMIAN AIDS RETROVIRUS SRV-1;

EID: 0033843219     PISSN: 09697128     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.gt.3301262     Document Type: Article

References (17)

1. Development of HIV vectors for anti-HIV gene therapy
2. Anti-HIV effects of HIV vectors
3. A conditionally replicating HIV-1 vector interferes with wild-type HIV-1 replication and spread
4. An inducible human immunodeficiency virus type 1 (HIV-1) vector which effectively suppresses HIV-1 replication
5. Interaction of human immunodeficiency virus-derived vectors with wild-type virus in transduced cells
6. Functional dissection of the HIV-1 Rev trans-activator - Derivation of a transdominant repressor of rev function
7. Analysis of trans-dominant mutants of the HIV type 1 rev protein for their ability to inhibit rev function, HIV type 1 replication, and their use as anti-HIV gene therapeutics
8. Requirements for efficient production and transduction of human immunodeficiency virus type 1-based vectors
9. Minimal requirement for a lentivirus vector based on human immunodeficiency virus type 1
10. A lentivirus packaging system based on alternative RNA transport mechanisms to express helper and gene transfer vector RNAs and its use to study the requirement of accessory proteins for particle formation and gene delivery
11. The effect of viral regulatory protein expression on gene delivery by human immunodeficiency virus type 1 vectors produced in stable packaging cell lines
12. Rev/RRE-independent Mason-Pfizer monkey virus constitutive transport element-dependent propagation of SIVmac239 vectors using a single round of replication assay
13. Continuous propagation of RRE(-) and Rev(-)RRE(-) human immunodeficiency virus type 1 molecular clones containing a cis-acting element of simian retrovirus type 1 in human peripheral blood lymphocytes
14. Modified HIV-based lentiviral vectors display decreased sensitivity to transdominant Rev
15. Efficient transfer, integration, and sustained long-term expression of the transgene in adult rat brains injected with a lentiviral vector
16. A structured retroviral RNA element that mediates nucleocytoplasmic export of intron-containing RNA
17. Mason-Pfizer monkey virus (MPMV) constitutive transport element (CTE) functions in a position-dependent manner