Suppression of TNF-α production in human mononuclear cells by an adenosine kinase inhibitor

Journal of Leukocyte Biology

Volumn 68, Issue 1, 2000, Pages 97-103

  Eigler, A ^a   Matschke, V ^a   Hartmann, G ^a   Erhardt, S ^a   Boyle, D ^a   Firestein, G S ^a   Endres, S ^a  

^a UNIVERSITY OF MUNICH   (Germany)

Author keywords

Cytokines; Lipopolysaccharide; Second messengers

Indexed keywords

4 AMINO 3 BROMOPYRAZOLO[3,4 D]PYRIMIDINE 1 (5 AMINO 5 DEOXYRIBOSIDE); ADENOSINE; ADENOSINE KINASE; ADENOSINE KINASE INHIBITOR; ANTIINFLAMMATORY AGENT; CYCLIC AMP; GP 515; INTERLEUKIN 10; LIPOPOLYSACCHARIDE; ROLIPRAM; TUMOR NECROSIS FACTOR ALPHA;

ANTIINFLAMMATORY ACTIVITY; ARTICLE; CHRONIC INFLAMMATION; CYTOKINE PRODUCTION; DOSE RESPONSE; DRUG EFFECT; ENZYME PHOSPHORYLATION; HUMAN; HUMAN CELL; MONONUCLEAR CELL; PRIORITY JOURNAL;

ADENOSINE; ADENOSINE KINASE; ADENOSINE MONOPHOSPHATE; ADULT; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CYCLIC AMP; CYCLIC AMP-DEPENDENT PROTEIN KINASES; DEPRESSION, CHEMICAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SYNERGISM; ENZYME INHIBITORS; HUMANS; INTERLEUKIN-10; LEUKOCYTES, MONONUCLEAR; PHOSPHODIESTERASE INHIBITORS; RIBONUCLEOSIDES; ROLIPRAM; SECOND MESSENGER SYSTEMS; THIONUCLEOTIDES; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0033840203     PISSN: 07415400     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (36)

1. 2 receptors
2. Adenosine inhibits neutrophil degranulation in activated human whole blood: Involvement of adenosine A2 and A3 receptors
3. Differential regulatory effects of adenosine on cytokine release by activated human monocytes
4. Adenosine enhances IL-10 secretion by human monocytes. J. Immunol
5. Endogenous adenosine curtails lipopolysaccharide-stimulated tumour necrosis factor synthesis
6. Adenosine and a related carbocyclic nucleoside analogue selectively inhibit tumor necrosis factor-α production and protect mice against endotoxin challenge
7. Protective effect of an adenosine kinase inhibitor in septic shock
8. Anti-inflammatory effects of an adenosine kinase inhibitor
9. Inhibition of neutrophil adhesion by adenosine and an adenosine kinase inhibitor
10. Repeated therapy with monoclonal antibody to tumour necrosis factor-α (cA2) in patients with rheumatoid arthritis
11. Randomised double-blind comparison of chimeric monoclonal antibody to tumour necrosis factor-α (cA2) versus placebo in rheumatoid arthritis
12. Prevention of Jarisch-Herxheimer reactions by treatment with antibodies against tumor necrosis factor-α
13. Taming TNF: Strategies to restrain this proinflammatory cytokine
14. Interleukin 10 (IL-10) inhibits cytokine synthesis by human monocytes: An autoregulatory role of IL-10 produced by monocytes
15. Interleukin-10 controls interferon-γ and tumor necrosis factor production during experimental endotoxemia
16. Macrophage deactivation by interleukin 10
17. Interleukin-10 inhibits B7 and intercellular adhesion molecule-1 expression on human monocytes
18. Isolation of mononuclear cells and granulocytes from human blood. Isolation of monuclear cells by one centrifugation, and of granulocytes by combining centrifugation and sedimentation at 1 g
19. Measurement of immunoreactive interleukin-1b from human mononuclear cells: Optimization of recovery, intrasubject consistency, and comparison with interleukin-1a and tumor necrosis factor
20. Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays
21. Spontaneous and cationic lipid-mediated uptake of antisense oligonucleotides in human monocytes and lymphocytes
22. The specific type IV phosphodiesterase inhibitor rolipram suppresses tumor necrosis factor-α production by human mononuclear cells
23. Suppression of lipopolysaccharide-induced tumor necrosis factor-α generation from human peripheral blood monocytes by inhibitors of phosphodiesterase 4: Interaction with stimulants of adenylyl cyclase
24. Anti-inflammatory activities of cAMP-elevating agents: Enhancement of IL-10 synthesis and concurrent suppression of TNF production
25. The antiinflammatory effects of an adenosine kinase inhibitor are mediated by adenosine
26. Turnover of adenosine in plasma of human and dog blood
27. Acting via A2 receptors, adenosine inhibits the production of tumor necrosis factor-α of endotoxin-stimulated human polymorphonuclear leukocytes
28. Suppression of lipopolysaccharide-stimulated release of tumor necrosis factor by adenosine: Evidence for A2 receptors on rat Kupffer cells
29. Cellular and molecular regulation of tumor necrosis factor-α production by pentoxifylline
30. Regulation of tumor necrosis factor expression in a macrophage-like cell line by lipopolysaccharide and cyclic AMP
31. Lipopolysaccharide-induced gene expression in murine peritoneal macrophages is selectively suppressed by agents that elevate intracellular cAMP
32. Enhanced tumor necrosis factor suppression and cyclic adenosine monophosphate accumulation by combination of phosphodiesterase inhibitors and prostanoids
33. Inhibition of TNF-α expression by adenosine: Role of A3 adenosine receptors
34. (Rp)-cAMPS inhibits the cAMP-dependent protein kinase by blocking the cAMP-induced conformational transition
35. Prostacyclin analogs suppress the synthesis of tumor necrosis factor-α in LPS-stimulated human peripheral blood mononuclear cells