2D and 3D QSAR analysis of some valproic acid metabolites and analogues as anticonvulsant agents

Pharmaceutical Research

Volumn 17, Issue 6, 2000, Pages 727-782

  Netzeva, Tatiana ^a   Doytchinova, Irini ^a   Natcheva, Roumiana ^a  

^a MEDICAL UNIVERSITY OF SOFIA   (Bulgaria)

Author keywords

Anticonvulsant activity; Lipophilicity; Quantitative structure activity relationship analysis (QSAR); Quantum mechanics; Valproic acid

Indexed keywords

VALPROIC ACID DERIVATIVE; VALPROMIDE;

ANTICONVULSANT THERAPY; ARTICLE; DRUG CONFORMATION; DRUG METABOLISM; DRUG STRUCTURE; INTERMETHOD COMPARISON; LIPOPHILICITY; PRIORITY JOURNAL; QUANTITATIVE STRUCTURE ACTIVITY RELATION; STATISTICAL MODEL;

ANTICONVULSANTS; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; VALPROIC ACID;

EID: 0033840159     PISSN: 07248741     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1007538517470     Document Type: Article

References (20)

1. Aprochess dans la pharmacodinamique biochimique de la structure N-dipropylacetique
2. Effects of valproate on xenobiotic biotransformation in rat liver. In vivo and in vitro experiments
3. Valproic acid: Update on its mechanisms of action
4. Valproic acid. A reappraisal of its pharmacological properties and clinical efficacy in epilepsy
5. Additive incidence of developmental malformation for Xenopus embryos exposed to a mixture of ten aliphatic carboxylic acids
6. Synthesis of GABA-valproic acid derivatives and evaluation of their anti-convulsant and antioxidant activity
7. Structure-pharmacokinetic relationships in a series of valpromide derivatives with antiepileptic activity
8. Structure-pharmacokinetic relationships in a series of short fatty acid amides that possess anticonvulsant activity
9. Pharmacological evaluation of varios metabolites and analogues of valproic acid
10. Chemical protection against ionizing radiation
11. Iterative partial equalization of orbital electronegativity - A rapid access to atomic charges
12. AM1: A new general purpose quantum mechanical molecular model
13. A new development of the OASIS computer system for modeling molecular properties
14. Cross-validatory estimation of the number of components in factor and principal components models
15. Comparative molecular field analysis (CoMFA). 1. Effect of shape on binding of steroids to carrier proteins
16. Multivariate structure-activity relationships between data from a battery of biological tests and an ensemble of chemical descriptors: The PLS method
17. Octanol - Water partition coefficients of simple organic compounds
18. Pattern recognition display methods for the analysis of computed molecular properties