Site-directed mutagenesis implicates a threonine residue in TM6 in the subtype selectivities of UH-AH 37 and pirenzepine at muscarinic receptors

Pharmacology

Volumn 61, Issue 2, 2000, Pages 62-69

  Ellis, John ^a,b   Seidenberg, Margaret ^a  

^a PENN STATE COLLEGE OF MEDICINE   (United States)

^b PENN STATE MILTON S HERSHEY MEDICAL CENTER   (United States)

Author keywords

4 DAMP; AF DX 116; Amino acid sequence; Mutagenesis; Pirenzepine; Receptors, muscarinic; Threonine; UH AH 37

Indexed keywords

4 DIPHENYLACETOXY 1 METHYLPIPERIDINE; 6 CHLORO 5,10 DIHYDRO 5 [(1 METHYL 4 PIPERIDYL)ACETYL] 11H DIBENZO[B,E][1,4]DIAZEPIN 11 ONE; MUSCARINIC M1 RECEPTOR; MUSCARINIC M2 RECEPTOR; MUSCARINIC M3 RECEPTOR; MUSCARINIC M4 RECEPTOR; MUSCARINIC M5 RECEPTOR; MUSCARINIC RECEPTOR; OTENZEPAD; PIRENZEPINE; THREONINE;

ALLOSTERISM; ANIMAL CELL; ARTICLE; DRUG BINDING SITE; DRUG CONFORMATION; DRUG RECEPTOR BINDING; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; RECEPTOR AFFINITY; SITE DIRECTED MUTAGENESIS;

EID: 0033839685     PISSN: 00317012     EISSN: None     Source Type: Journal    
DOI: 10.1159/000028382     Document Type: Article

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